Showing entry for Ficolin-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013574
Protein NameFicolin-2
Uniport IdQ15485
GeneFCN2
Gene Id2220
DomainCollagen; Fibrinogen_C
Pfam PF01391   PF00147  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006956 complement activation
Biological Process GO:0001867 complement activation, lectin pathway
Biological Process GO:0050829 defense response to Gram-negative bacterium
Biological Process GO:0050830 defense response to Gram-positive bacterium
Biological Process GO:0008228 opsonization
Biological Process GO:0043654 recognition of apoptotic cell
molecular function GO:0003823 antigen binding
molecular function GO:0048306 calcium-dependent protein binding
molecular function GO:0097367 carbohydrate derivative binding
molecular function GO:2001065 mannan binding
molecular function GO:0046872 metal ion binding
molecular function GO:0043394 proteoglycan binding
molecular function GO:0005102 signaling receptor binding
cellular component GO:0072562 blood microparticle
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0005581 collagen trimer
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
Reactome
Pathway Id Pathway Name
R-HSA-166658 Complement cascade
R-HSA-166662 Lectin pathway of complement activation
R-HSA-166663 Initial triggering of complement
R-HSA-166786 Creation of C4 and C2 activators
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006267 BXGD000383 Bronchiectasis Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009447 BXGD000613 Common Variable Immunodeficiency Immune System Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013589 BXGD000856 Ectromelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0014060 BXGD000882 Encephalitis, St. Louis Infections; Nervous System Diseases
C0014740 BXGD000944 Erythema Chronicum Migrans Infections; Skin and Connective Tissue Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017574 BXGD001122 Gingivitis Infections; Stomatognathic Diseases
C0017677 BXGD001147 Glossitis, Benign Migratory Stomatognathic Diseases
C0019156 BXGD001292 Hepatic Veno-Occlusive Disease Digestive System Diseases; Cardiovascular Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023281 BXGD001628 Leishmaniasis Infections; Skin and Connective Tissue Diseases
C0023283 BXGD001629 Leishmaniasis, Cutaneous Infections; Skin and Connective Tissue Diseases
C0023290 BXGD001631 Leishmaniasis, Visceral Infections
C0023343 BXGD001635 Leprosy Infections
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024198 BXGD001743 Lyme Disease Infections
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024530 BXGD001783 Malaria Infections
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026847 BXGD001940 Spinal Muscular Atrophy Nervous System Diseases
C0026916 BXGD001947 Mycobacterium avium-intracellulare Infection Infections
C0026918 BXGD001948 Mycobacterium Infections Infections
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027697 BXGD002022 Nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030524 BXGD002236 Paratuberculosis Infections; Animal Diseases
C0030807 BXGD002257 Pemphigus Skin and Connective Tissue Diseases; Immune System Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0032269 BXGD002342 Pneumococcal Infections Infections
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035204 BXGD002511 Respiration Disorders Respiratory Tract Diseases
C0035242 BXGD002521 Respiratory Tract Diseases Respiratory Tract Diseases
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0035344 BXGD002541 Retinopathy of Prematurity Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0035436 BXGD002550 Rheumatic Fever Infections; Musculoskeletal Diseases
C0035439 BXGD002551 Rheumatic Heart Disease Infections; Cardiovascular Diseases
C0035920 BXGD002570 Rubella Infections
C0036323 BXGD002595 Schistosomiasis Infections
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037354 BXGD002690 Smallpox Infections
C0038395 BXGD002753 Streptococcal Infections Infections
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039483 BXGD002813 Giant Cell Arteritis Skin and Connective Tissue Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0040425 BXGD002863 Tonsillitis Infections; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0041234 BXGD002901 Chagas Disease Infections
C0041296 BXGD002903 Tuberculosis Infections
C0041327 BXGD002916 Tuberculosis, Pulmonary Infections; Respiratory Tract Diseases
C0041341 BXGD002918 Tuberous Sclerosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0079745 BXGD003091 Lymphoma, Large-Cell, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085084 BXGD003121 Motor Neuron Disease Nervous System Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0158944 BXGD003912 Infections specific to perinatal period Pathological Conditions, Signs and Symptoms; Infections
C0175708 BXGD004012 Chronic rheumatic heart disease Infections; Cardiovascular Diseases
C0206062 BXGD004148 Lung Diseases, Interstitial Respiratory Tract Diseases
C0206716 BXGD004262 Ganglioglioma Neoplasms
C0220756 BXGD004338 Niemann-Pick Disease, Type C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238462 BXGD004937 Medullary carcinoma of thyroid Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242381 BXGD005159 Lyme Arthritis Infections
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0279584 BXGD006641 Childhood B Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0279593 BXGD006644 Adult B Acute Lymphoblastic Leukemia
C0333519 BXGD006958 Caries (morphologic abnormality) Pathological Conditions, Signs and Symptoms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0343804 BXGD007648 Chronic Chagas' disease Infections
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349636 BXGD007941 Pre B-cell acute lymphoblastic leukemia
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0396023 BXGD008179 Chronic adenoiditis
C0396024 BXGD008180 Chronic adenotonsillitis
C0398650 BXGD008212 Immune thrombocytopenic purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0694549 BXGD009851 Community acquired pneumonia Infections; Respiratory Tract Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0750901 BXGD010242 Alzheimer Disease, Early Onset Nervous System Diseases; Mental Disorders
C0858004 BXGD011168 Influenza A virus infection Infections; Respiratory Tract Diseases
C0863094 BXGD011271 Recurrent respiratory tract infections
C0869523 BXGD011307 Carditis Cardiovascular Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1292769 BXGD012230 Precursor B-cell lymphoblastic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1320214 BXGD012421 Invasive Streptococcus pneumoniae disease Infections
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1562113 BXGD013372 Fleck corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1562908 BXGD013381 Leprosy, Paucibacillary Infections
C1609538 BXGD013444 Latent Tuberculosis Infections
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1704430 BXGD013562 Urinary Schistosomiasis Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1848199 BXGD014912 X-Linked Lissencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1855179 BXGD015468 CATARACT, ANTERIOR POLAR Eye Diseases
C2062441 BXGD016897 Influenza A
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2363741 BXGD017100 HIV-1 infection
C2747816 BXGD017577 Complicated malaria Infections
C2936664 BXGD018125 Acquired Hypogammaglobulinemia Immune System Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3151085 BXGD018392 MASP2 Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C3203547 BXGD018566 Axial spondyloarthritis Musculoskeletal Diseases
C3280586 BXGD018846 Mannose-Binding Protein Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4025320 BXGD021643 Craniofacial asymmetry Pathological Conditions, Signs and Symptoms
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4721532 BXGD023752 Lymphoma, Non-Hodgkin, Familial Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0003102 Acetylcholine 146.21
BXGC0005620 beta-D-Glucopyranose 180.16
BXGC0018397 beta-1,4-mannan 180.06
BXGC0027956 SHU 508 180.06
BXGC0033112 Acetylcysteine 163.03
BXGC0049447 acetate 59.01
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein