Showing entry for SUMO-conjugating enzyme UBC9


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011514
Protein NameSUMO-conjugating enzyme UBC9
Uniport IdP63279
GeneUBE2I
Gene Id7329
DomainUQ_con
Pfam PF00179  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa03013 RNA transport
3. Environmental Information Processing 3.2 Signal transduction hsa04064 NF-kappa B signaling pathway
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis
6. Human Diseases 6.1 Cancers: Overview hsa05206 MicroRNAs in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007049 cell cycle
Biological Process GO:0051301 cell division
Biological Process GO:0006464 cellular protein modification process
Biological Process GO:0007059 chromosome segregation
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:1903755 positive regulation of SUMO transferase activity
Biological Process GO:0016925 protein sumoylation
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
Biological Process GO:0016032 viral process
molecular function GO:0005524 ATP binding
molecular function GO:0019899 enzyme binding
molecular function GO:0043398 HLH domain binding
molecular function GO:0071535 RING-like zinc finger domain binding
molecular function GO:0003723 RNA binding
molecular function GO:0044388 small protein activating enzyme binding
molecular function GO:0061656 SUMO conjugating enzyme activity
molecular function GO:0019789 SUMO transferase activity
molecular function GO:0001221 transcription cofactor binding
molecular function GO:0008134 transcription factor binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005635 nuclear envelope
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0016605 PML body
cellular component GO:1990356 sumoylated E2 ligase complex
cellular component GO:0000795 synaptonemal complex
cellular component GO:1990234 transferase complex
Reactome
Pathway Id Pathway Name
R-HSA-1221632 Meiotic synapsis
R-HSA-1430728 Metabolism
R-HSA-1474165 Reproduction
R-HSA-1500620 Meiosis
R-HSA-1640170 Cell Cycle
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-196791 Vitamin D (calciferol) metabolism
R-HSA-212436 Generic Transcription Pathway
R-HSA-212436 Generic Transcription Pathway
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-2990846 SUMOylation
R-HSA-2990846 SUMOylation
R-HSA-2995410 Nuclear Envelope (NE) Reassembly
R-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)
R-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-3215018 Processing and activation of SUMO
R-HSA-3215018 Processing and activation of SUMO
R-HSA-3232118 SUMOylation of transcription factors
R-HSA-3232118 SUMOylation of transcription factors
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-392499 Metabolism of proteins
R-HSA-392499 Metabolism of proteins
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4090294 SUMOylation of intracellular receptors
R-HSA-4090294 SUMOylation of intracellular receptors
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-4655427 SUMOylation of DNA methylation proteins
R-HSA-4655427 SUMOylation of DNA methylation proteins
R-HSA-4755510 SUMOylation of immune response proteins
R-HSA-556833 Metabolism of lipids
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693538 Homology Directed Repair
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
R-HSA-5693606 DNA Double Strand Break Response
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696398 Nucleotide Excision Repair
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-597592 Post-translational protein modification
R-HSA-597592 Post-translational protein modification
R-HSA-68882 Mitotic Anaphase
R-HSA-68886 M Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73894 DNA Repair
R-HSA-74160 Gene expression (Transcription)
R-HSA-74160 Gene expression (Transcription)
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-8957322 Metabolism of steroids
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation
R-HSA-9678108 SARS-CoV-1 Infection
R-HSA-9679506 SARS-CoV Infections
R-HSA-9679506 SARS-CoV Infections
R-HSA-9683610 Maturation of nucleoprotein
R-HSA-9683701 Translation of structural proteins
R-HSA-9694516 SARS-CoV-2 Infection
R-HSA-9694631 Maturation of nucleoprotein
R-HSA-9694635 Translation of structural proteins
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002690 BXGD000124 Amputation Stumps
C0003872 BXGD000235 Arthritis, Psoriatic Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0005859 BXGD000342 Bloom Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019104 BXGD001285 Hemorrhagic Fevers, Viral Infections
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0020502 BXGD001410 Hyperparathyroidism Endocrine System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023092 BXGD001609 Lassa Fever Infections
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0023508 BXGD001675 White Blood Cell Count procedure
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024667 BXGD001794 Animal Mammary Neoplasms Neoplasms; Animal Diseases
C0024668 BXGD001795 Mammary Neoplasms, Experimental Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028945 BXGD002099 oligodendroglioma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0035344 BXGD002541 Retinopathy of Prematurity Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079745 BXGD003091 Lymphoma, Large-Cell, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085395 BXGD003161 Ureaplasma Infections Infections
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0156149 BXGD003839 Gastrointestinal tract vascular insufficiency Digestive System Diseases
C0162309 BXGD003934 Adrenoleukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0162635 BXGD003964 Angelman Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205696 BXGD004107 Anaplastic carcinoma Neoplasms
C0205697 BXGD004108 Carcinoma, Spindle-Cell Neoplasms
C0205698 BXGD004109 Undifferentiated carcinoma Neoplasms
C0205699 BXGD004110 Carcinomatosis Neoplasms
C0206093 BXGD004154 Neuroectodermal Tumors Neoplasms
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0238462 BXGD004937 Medullary carcinoma of thyroid Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242510 BXGD005173 Drug usage Chemically-Induced Disorders; Mental Disorders
C0262404 BXGD005236 Cerebellar degeneration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0262587 BXGD005259 Parathyroid Adenoma Neoplasms; Endocrine System Diseases
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0332447 BXGD006891 Morphologically abnormal structure (morphologic abnormality)
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751396 BXGD010425 Well Differentiated Oligodendroglioma Neoplasms
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0871470 BXGD011316 Systolic Pressure
C0919909 BXGD011448 Tonic clonic movements
C0936223 BXGD011477 Metastatic Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1175175 BXGD011797 Severe Acute Respiratory Syndrome Infections; Respiratory Tract Diseases
C1257925 BXGD011814 Mammary Carcinoma, Animal Neoplasms; Animal Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1282496 BXGD012147 Metastasis from malignant tumor of prostate
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1527349 BXGD013277 Ductal Breast Carcinoma Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C1833921 BXGD013946 Familial medullary thyroid carcinoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C1859726 BXGD015926 ARTERIAL TORTUOSITY SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2004435 BXGD016871 Vascular insufficiency of intestine Digestive System Diseases; Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2699510 BXGD017460 Split-Hand/Foot Malformation Pathological Conditions, Signs and Symptoms
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4721532 BXGD023752 Lymphoma, Non-Hodgkin, Familial Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006368 Formic acid 46.03
BXGC0026607 epiberberine 336.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein