protein

Showing entry for Ubiquitin carboxyl-terminal hydrolase isozyme L1

General Target Information
BXGT Id	BXGT006943
Protein Name	Ubiquitin carboxyl-terminal hydrolase isozyme L1
Uniport Id	P09936
Gene	UCHL1
Gene Id	7345
Domain	Peptidase_C12
Pfam	PF01088
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
6. Human Diseases	6.4 Neurodegenerative diseases	hsa05012	Parkinson disease

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0007628	adult walking behavior
Biological Process	GO:0019896	axonal transport of mitochondrion
Biological Process	GO:0007412	axon target recognition
Biological Process	GO:0008283	cell population proliferation
Biological Process	GO:0035690	cellular response to drug
Biological Process	GO:0042755	eating behavior
Biological Process	GO:0048747	muscle fiber development
Biological Process	GO:0043407	negative regulation of MAP kinase activity
Biological Process	GO:0050905	neuromuscular process
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process	GO:0016579	protein deubiquitination
Biological Process	GO:0016241	regulation of macroautophagy
Biological Process	GO:0002931	response to ischemia
Biological Process	GO:0019233	sensory perception of pain
molecular function	GO:0031694	alpha-2A adrenergic receptor binding
molecular function	GO:0004197	cysteine-type endopeptidase activity
molecular function	GO:0016874	ligase activity
molecular function	GO:0008242	omega peptidase activity
molecular function	GO:0004843	thiol-dependent ubiquitin-specific protease activity
molecular function	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
molecular function	GO:0043130	ubiquitin binding
molecular function	GO:0031625	ubiquitin protein ligase binding
cellular component	GO:1904115	axon cytoplasm
cellular component	GO:0005737	cytoplasm
cellular component	GO:0005829	cytosol
cellular component	GO:0005789	endoplasmic reticulum membrane
cellular component	GO:0043025	neuronal cell body
cellular component	GO:0044306	neuron projection terminus

Reactome

Pathway Id	Pathway Name
R-HSA-392499	Metabolism of proteins
R-HSA-5688426	Deubiquitination
R-HSA-5689603	UCH proteinases
R-HSA-597592	Post-translational protein modification

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0001418	BXGD000050	Adenocarcinoma	Neoplasms
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0002726	BXGD000125	Amyloidosis	Nutritional and Metabolic Diseases
C0002736	BXGD000127	Amyotrophic Lateral Sclerosis	Nutritional and Metabolic Diseases; Nervous System Diseases
C0003467	BXGD000194	Anxiety	Behavior and Behavior Mechanisms
C0003615	BXGD000212	Appendicitis	Digestive System Diseases; Infections
C0004045	BXGD000249	Asphyxia Neonatorum	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0004134	BXGD000256	Ataxia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004238	BXGD000262	Atrial Fibrillation	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007095	BXGD000423	Carcinoid Tumor	Neoplasms
C0007097	BXGD000424	Carcinoma	Neoplasms
C0007102	BXGD000425	Malignant tumor of colon	Digestive System Diseases; Neoplasms
C0007103	BXGD000426	Malignant neoplasm of endometrium	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007115	BXGD000432	Malignant neoplasm of thyroid	Neoplasms; Endocrine System Diseases
C0007131	BXGD000441	Non-Small Cell Lung Carcinoma	Neoplasms; Respiratory Tract Diseases
C0007134	BXGD000443	Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137	BXGD000445	Squamous cell carcinoma	Neoplasms
C0007758	BXGD000475	Cerebellar Ataxia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007785	BXGD000485	Cerebral Infarction	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007873	BXGD000500	Uterine Cervical Neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009398	BXGD000604	Color vision defect	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0009404	BXGD000606	Colorectal Neoplasms	Digestive System Diseases; Neoplasms
C0009447	BXGD000613	Common Variable Immunodeficiency	Immune System Diseases
C0009806	BXGD000633	Constipation	Pathological Conditions, Signs and Symptoms
C0010417	BXGD000670	Cryptorchidism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0010674	BXGD000683	Cystic Fibrosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011206	BXGD000703	Delirium	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0011265	BXGD000708	Presenile dementia	Nervous System Diseases; Mental Disorders
C0011570	BXGD000729	Mental Depression	Behavior and Behavior Mechanisms
C0011581	BXGD000733	Depressive disorder	Mental Disorders
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881	BXGD000760	Diabetic Nephropathy	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011991	BXGD000766	Diarrhea	Pathological Conditions, Signs and Symptoms
C0012569	BXGD000777	Diplopia	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0013363	BXGD000818	Dysautonomia	Nervous System Diseases
C0013384	BXGD000826	Dyskinetic syndrome	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421	BXGD000837	Dystonia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014060	BXGD000882	Encephalitis, St. Louis	Infections; Nervous System Diseases
C0014175	BXGD000904	Endometriosis	Female Urogenital Diseases and Pregnancy Complications
C0014544	BXGD000926	Epilepsy	Nervous System Diseases
C0014859	BXGD000961	Esophageal Neoplasms	Digestive System Diseases; Neoplasms
C0015644	BXGD001008	Muscular fasciculation	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0016202	BXGD001050	Flatfoot	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0016978	BXGD001087	gallbladder neoplasm	Digestive System Diseases; Neoplasms
C0017525	BXGD001112	Giant Cell Tumors	Neoplasms
C0017638	BXGD001132	Glioma	Neoplasms
C0017658	BXGD001138	Glomerulonephritis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0017665	BXGD001141	Membranous glomerulonephritis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018524	BXGD001200	Hallucinations	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0019196	BXGD001301	Hepatitis C	Digestive System Diseases; Infections
C0019284	BXGD001312	Diaphragmatic Hernia	Pathological Conditions, Signs and Symptoms
C0019621	BXGD001340	Histiocytosis, Langerhans-Cell	Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0019829	BXGD001350	Hodgkin Disease	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020179	BXGD001363	Huntington Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020456	BXGD001392	Hyperglycemia	Nutritional and Metabolic Diseases
C0021125	BXGD001483	Impulsive Behavior	Behavior and Behavior Mechanisms
C0022658	BXGD001570	Kidney Diseases	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022735	BXGD001581	Klinefelter Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0023449	BXGD001650	Acute lymphocytic leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023896	BXGD001718	Alcoholic Liver Diseases	Digestive System Diseases; Chemically-Induced Disorders
C0024121	BXGD001735	Lung Neoplasms	Neoplasms; Respiratory Tract Diseases
C0024141	BXGD001740	Lupus Erythematosus, Systemic	Skin and Connective Tissue Diseases; Immune System Diseases
C0024143	BXGD001741	Lupus Nephritis	Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024299	BXGD001758	Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623	BXGD001791	Malignant neoplasm of stomach	Digestive System Diseases; Neoplasms
C0025202	BXGD001832	melanoma	Neoplasms
C0025286	BXGD001850	Meningioma	Neoplasms; Nervous System Diseases
C0025517	BXGD001875	Metabolic Diseases	Nutritional and Metabolic Diseases
C0026764	BXGD001928	Multiple Myeloma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026837	BXGD001937	Muscle Rigidity	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026838	BXGD001938	Muscle Spasticity	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026847	BXGD001940	Spinal Muscular Atrophy	Nervous System Diseases
C0026948	BXGD001952	Mycosis Fungoides	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027092	BXGD001971	Myopia	Eye Diseases
C0027497	BXGD001993	Nausea	Pathological Conditions, Signs and Symptoms
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027697	BXGD002022	Nephritis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027746	BXGD002032	Nerve Degeneration	Pathological Conditions, Signs and Symptoms
C0027765	BXGD002033	nervous system disorder	Nervous System Diseases
C0027819	BXGD002043	Neuroblastoma	Neoplasms
C0028738	BXGD002081	Nystagmus	Eye Diseases; Nervous System Diseases
C0029124	BXGD002113	Optic Atrophy	Eye Diseases; Nervous System Diseases
C0029463	BXGD002160	Osteosarcoma	Neoplasms
C0030193	BXGD002191	Pain	Pathological Conditions, Signs and Symptoms
C0030481	BXGD002228	Tropical Spastic Paraparesis	Infections; Nervous System Diseases
C0030521	BXGD002235	Parathyroid Neoplasms	Neoplasms; Endocrine System Diseases
C0030567	BXGD002240	Parkinson Disease	Nervous System Diseases
C0034935	BXGD002497	Babinski Reflex
C0035258	BXGD002523	Restless Legs Syndrome	Nervous System Diseases; Mental Disorders
C0035309	BXGD002530	Retinal Diseases	Eye Diseases
C0036161	BXGD002580	Sandhoff Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0036220	BXGD002587	Kaposi Sarcoma	Neoplasms; Infections
C0036341	BXGD002600	Schizophrenia	Mental Disorders
C0036572	BXGD002625	Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690	BXGD002632	Septicemia	Pathological Conditions, Signs and Symptoms; Infections
C0037763	BXGD002699	Spasm	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037772	BXGD002703	Spastic Paraplegia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037773	BXGD002704	Spastic Paraplegia, Hereditary	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0038220	BXGD002740	Status Epilepticus	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038454	BXGD002760	Cerebrovascular accident	Nervous System Diseases; Cardiovascular Diseases
C0039273	BXGD002806	Talipes cavus	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0040136	BXGD002845	Thyroid Neoplasm	Neoplasms; Endocrine System Diseases
C0040822	BXGD002885	Tremor	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041696	BXGD002932	Unipolar Depression	Mental Disorders
C0042373	BXGD002978	Vascular Diseases	Cardiovascular Diseases
C0079731	BXGD003087	B-Cell Lymphomas	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744	BXGD003090	Diffuse Large B-Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079772	BXGD003099	T-Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085084	BXGD003121	Motor Neuron Disease	Nervous System Diseases
C0085167	BXGD003137	Granular cell tumor	Neoplasms
C0085631	BXGD003214	Agitation	Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085632	BXGD003215	Apathy	Behavior and Behavior Mechanisms
C0085681	BXGD003237	Hyperphosphatemia (disorder)	Nutritional and Metabolic Diseases
C0085693	BXGD003241	Acute appendicitis NOS (disorder)	Digestive System Diseases; Infections
C0086543	BXGD003294	Cataract	Eye Diseases
C0086769	BXGD003310	Panic Attacks	Mental Disorders
C0149678	BXGD003346	Epstein-Barr Virus Infections	Infections
C0149925	BXGD003387	Small cell carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0150080	BXGD003402	Social Communication Disorder	Mental Disorders
C0151889	BXGD003498	Hyperreflexia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013	BXGD003516	Adenocarcinoma of lung (disorder)	Neoplasms
C0152020	BXGD003519	Gastroparesis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0153452	BXGD003647	Malignant neoplasm of gallbladder	Digestive System Diseases; Neoplasms
C0153676	BXGD003679	Secondary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0162309	BXGD003934	Adrenoleukodystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0205647	BXGD004099	Follicular adenoma	Neoplasms
C0206663	BXGD004225	Neuroectodermal Tumor, Primitive	Neoplasms
C0206698	BXGD004248	Cholangiocarcinoma	Neoplasms
C0206718	BXGD004264	Ganglioneuroblastoma	Neoplasms
C0206754	BXGD004289	Neuroendocrine Tumors	Neoplasms
C0220620	BXGD004299	Gastrointestinal Carcinoid Tumor	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0220668	BXGD004317	Congenital contractural arachnodactyly	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221026	BXGD004371	X-linked agammaglobulinemia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0221052	BXGD004380	Chronic berylliosis	Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases; Occupational Diseases; Wounds and Injuries
C0233565	BXGD004590	Bradykinesia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234162	BXGD004627	Cerebellar Dysmetria	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235782	BXGD004769	Gallbladder Carcinoma	Digestive System Diseases; Neoplasms
C0235820	BXGD004772	Neonatal encephalopathy	Nervous System Diseases
C0235946	BXGD004789	Cerebral atrophy	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0238651	BXGD004951	Ankle clonus
C0241932	BXGD005126	X-linked hypogammaglobulinemia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0242363	BXGD005156	Islet Cell Tumor	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379	BXGD005157	Malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0242422	BXGD005163	Parkinsonian Disorders	Nervous System Diseases
C0243026	BXGD005210	Sepsis	Pathological Conditions, Signs and Symptoms; Infections
C0262630	BXGD005262	Reduced concentration span	Behavior and Behavior Mechanisms
C0268079	BXGD005812	Hyperphosphaturia	Nutritional and Metabolic Diseases
C0270790	BXGD006105	Quadriparesis	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0271650	BXGD006227	Impaired glucose tolerance	Nutritional and Metabolic Diseases
C0278097	BXGD006496	Abnormal male sexual function
C0279702	BXGD006685	Conventional (Clear Cell) Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0282201	BXGD006799	Phosphate Diabetes	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0302592	BXGD006851	Cervix carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0333068	BXGD006920	Flexion contracture	Musculoskeletal Diseases
C0338455	BXGD007177	Dementia of frontal lobe type	Nervous System Diseases; Mental Disorders
C0338656	BXGD007211	Impaired cognition	Mental Disorders
C0341439	BXGD007408	Chronic liver disease	Digestive System Diseases
C0344315	BXGD007666	Depressed mood	Behavior and Behavior Mechanisms
C0346153	BXGD007781	Breast Cancer, Familial	Neoplasms; Skin and Connective Tissue Diseases
C0346647	BXGD007832	Malignant neoplasm of pancreas	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0376545	BXGD008002	Hematologic Neoplasms	Neoplasms; Hemic and Lymphatic Diseases
C0393642	BXGD008111	Sepsis-Associated Encephalopathy	Nervous System Diseases
C0424295	BXGD008524	Hyperactive behavior	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0432474	BXGD008793	Klinefelter's syndrome - male with more than two X chromosomes	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0476089	BXGD008977	Endometrial Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0494165	BXGD009022	Secondary malignant neoplasm of liver	Digestive System Diseases; Neoplasms
C0497327	BXGD009061	Dementia	Nervous System Diseases; Mental Disorders
C0521707	BXGD009166	Bilateral cataracts (disorder)	Eye Diseases
C0524851	BXGD009246	Neurodegenerative Disorders	Nervous System Diseases
C0546837	BXGD009343	Malignant neoplasm of esophagus	Digestive System Diseases; Neoplasms
C0549473	BXGD009384	Thyroid carcinoma	Neoplasms; Endocrine System Diseases
C0555198	BXGD009432	Malignant Glioma	Neoplasms
C0585442	BXGD009593	Osteosarcoma of bone	Neoplasms
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766	BXGD009669	Leukemogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0677948	BXGD009739	Stage II Colorectal Cancer	Digestive System Diseases; Neoplasms
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684219	BXGD009789	Myokymia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0684337	BXGD009796	Ewings sarcoma-primitive neuroectodermal tumor (PNET)	Neoplasms
C0685938	BXGD009829	Malignant neoplasm of gastrointestinal tract	Digestive System Diseases; Neoplasms
C0686619	BXGD009835	Secondary malignant neoplasm of lymph node	Pathological Conditions, Signs and Symptoms; Neoplasms
C0687150	BXGD009842	Parathyroid Gland Adenocarcinoma	Neoplasms; Endocrine System Diseases
C0699791	BXGD009867	Stomach Carcinoma	Digestive System Diseases; Neoplasms
C0700095	BXGD009875	Central neuroblastoma	Neoplasms; Nervous System Diseases
C0740279	BXGD009973	Cerebellar atrophy
C0740391	BXGD009987	Middle Cerebral Artery Occlusion	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0752098	BXGD010660	Autosomal Dominant Parkinsonism	Nervous System Diseases
C0752304	BXGD010711	Hypoxic-Ischemic Encephalopathy	Nervous System Diseases; Cardiovascular Diseases
C0752335	BXGD010720	Neuropsychiatric Systemic Lupus Erythematosus	Infections; Skin and Connective Tissue Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0752347	BXGD010721	Lewy Body Disease	Nervous System Diseases; Mental Disorders
C0917801	BXGD011412	Sleeplessness	Nervous System Diseases; Mental Disorders
C0919267	BXGD011426	ovarian neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0947751	BXGD011494	Vascular inflammations	Cardiovascular Diseases
C0948008	BXGD011499	Ischemic stroke	Nervous System Diseases; Cardiovascular Diseases
C0948379	BXGD011533	Impaired insulin secretion
C1112256	BXGD011655	Sensorimotor neuropathy
C1112442	BXGD011668	Female sexual dysfunction
C1112443	BXGD011669	Male sexual dysfunction
C1140680	BXGD011718	Malignant neoplasm of ovary	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1145670	BXGD011764	Respiratory Failure	Respiratory Tract Diseases
C1265996	BXGD011927	Large cell neuroendocrine carcinoma	Neoplasms
C1269683	BXGD012001	Major Depressive Disorder	Mental Disorders
C1269955	BXGD012005	Tumor Cell Invasion
C1285162	BXGD012167	Degenerative disorder	Pathological Conditions, Signs and Symptoms
C1292753	BXGD012226	Primary Effusion Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306460	BXGD012362	Primary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C1332201	BXGD012502	Adult Diffuse Large B-Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332206	BXGD012504	Adult Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979	BXGD012571	Childhood Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332986	BXGD012574	Childhood Osteosarcoma	Neoplasms
C1334953	BXGD012746	Neuroblastic tumors	Neoplasms
C1337011	BXGD012874	Well Differentiated Pancreatic Endocrine Tumor	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1458155	BXGD013136	Mammary Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C1533172	BXGD013311	Infantile nystagmus syndrome	Eye Diseases; Nervous System Diseases
C1608410	BXGD013435	Head titubation
C1611743	BXGD013456	Familial (FPAH)
C1704321	BXGD013544	Nephrotic Syndrome, Minimal Change	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1836150	BXGD014082	Gait imbalance
C1839364	BXGD014371	Progressive visual loss
C1843921	BXGD014620	Postural instability	Nervous System Diseases
C1856689	BXGD015630	FRIEDREICH ATAXIA 1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1961102	BXGD016673	Precursor Cell Lymphoblastic Leukemia Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1963060	BXGD016679	Agitation, CTCAE 3.0
C1963184	BXGD016688	Nystagmus, CTCAE 3.0
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2364082	BXGD017123	Sense of smell impaired	Nervous System Diseases
C2678065	BXGD017398	Myofibrillar Myopathy	Musculoskeletal Diseases; Nervous System Diseases
C2931822	BXGD018068	Nasopharyngeal carcinoma	Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2936664	BXGD018125	Acquired Hypogammaglobulinemia	Immune System Diseases
C2939419	BXGD018178	Secondary Neoplasm	Pathological Conditions, Signs and Symptoms; Neoplasms
C3146252	BXGD018261	Stage II Colorectal Cancer AJCC v7
C3150899	BXGD018351	PARKINSON DISEASE 5, AUTOSOMAL DOMINANT
C3489532	BXGD018934	Cone-Rod Dystrophy 2	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3489791	BXGD018949	Parkinson Disease, Familial, Type 1	Nervous System Diseases
C3496337	BXGD019020	Idiopathic Nephrotic Syndrome	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3714934	BXGD019438	MYOPATHY, MYOFIBRILLAR, 3	Musculoskeletal Diseases; Nervous System Diseases
C3809665	BXGD019603	SPASTIC PARAPLEGIA 79, AUTOSOMAL RECESSIVE
C3810365	BXGD019652	Central visual impairment	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4086158	BXGD022124	Childhood Ganglioneuroblastoma	Neoplasms
C4086165	BXGD022126	Childhood Neuroblastoma	Neoplasms
C4317109	BXGD022725	Epileptic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4511452	BXGD023002	Sporadic Parkinson disease	Nervous System Diseases
C4552855	BXGD023528	Agitation, CTCAE 5.0
C4553743	BXGD023548	Spasticity, CTCAE
C4554036	BXGD023557	Nystagmus, CTCAE 5.0
C4721453	BXGD023744	Peripheral Nervous System Diseases	Nervous System Diseases
C4721772	BXGD023767	Postoperative delirium	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4722085	BXGD023788	Malignant neoplasm of colon and/or rectum
C4722099	BXGD023789	High grade glioma	Neoplasms

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0002953	2-Phenethyl isothiocyanate		163.24
BXGC0003705	Chloride		35.45
BXGC0014048	Celastrol		450.28
BXGC0044200	Menadione		172.05
BXGC0047877	Mangiferin		438.08

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}