Showing entry for Dynactin subunit 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013455
Protein NameDynactin subunit 1
Uniport IdQ14203
GeneDCTN1
Gene Id1639
DomainCAP_GLY; Dynactin
Pfam PF01302   PF12455  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.5 Excretory system hsa04962 Vasopressin-regulated water reabsorption
6. Human Diseases 6.4 Neurodegenerative diseases hsa05016 Huntington disease
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:0051301 cell division
Biological Process GO:0010457 centriole-centriole cohesion
Biological Process GO:0097711 ciliary basal body-plasma membrane docking
Biological Process GO:0031122 cytoplasmic microtubule organization
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0000132 establishment of mitotic spindle orientation
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
Biological Process GO:0036498 IRE1-mediated unfolded protein response
Biological Process GO:0099558 maintenance of synapse structure
Biological Process GO:0032402 melanosome transport
Biological Process GO:0034454 microtubule anchoring at centrosome
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0061744 motor behavior
Biological Process GO:0007399 nervous system development
Biological Process GO:0007528 neuromuscular junction development
Biological Process GO:0050905 neuromuscular process
Biological Process GO:0070050 neuron cellular homeostasis
Biological Process GO:1990535 neuron projection maintenance
Biological Process GO:1905515 non-motile cilium assembly
Biological Process GO:0051081 nuclear envelope disassembly
Biological Process GO:0007097 nuclear migration
Biological Process GO:0090063 positive regulation of microtubule nucleation
Biological Process GO:0031116 positive regulation of microtubule polymerization
Biological Process GO:1904398 positive regulation of neuromuscular junction development
Biological Process GO:0010389 regulation of G2/M transition of mitotic cell cycle
Biological Process GO:0060236 regulation of mitotic spindle organization
Biological Process GO:0042147 retrograde transport, endosome to Golgi
Biological Process GO:0010970 transport along microtubule
Biological Process GO:0021517 ventral spinal cord development
molecular function GO:0008017 microtubule binding
molecular function GO:0051010 microtubule plus-end binding
molecular function GO:0003774 motor activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0048156 tau protein binding
molecular function GO:0015631 tubulin binding
cellular component GO:0030424 axon
cellular component GO:0005938 cell cortex
cellular component GO:0099738 cell cortex region
cellular component GO:0031252 cell leading edge
cellular component GO:0120103 centriolar subdistal appendage
cellular component GO:0005814 centriole
cellular component GO:0005813 centrosome
cellular component GO:0036064 ciliary basal body
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0030286 dynein complex
cellular component GO:0045171 intercellular bridge
cellular component GO:0000776 kinetochore
cellular component GO:0016020 membrane
cellular component GO:0005874 microtubule
cellular component GO:0005875 microtubule associated complex
cellular component GO:0015630 microtubule cytoskeleton
cellular component GO:0035371 microtubule plus-end
cellular component GO:0072686 mitotic spindle
cellular component GO:0043025 neuronal cell body
cellular component GO:0043005 neuron projection
cellular component GO:0005635 nuclear envelope
cellular component GO:0005634 nucleus
cellular component GO:0005819 spindle
cellular component GO:0000922 spindle pole
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-199977 ER to Golgi Anterograde Transport
R-HSA-199991 Membrane Trafficking
R-HSA-2132295 MHC class II antigen presentation
R-HSA-2262752 Cellular responses to stress
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-381038 XBP1(S) activates chaperone genes
R-HSA-381070 IRE1alpha activates chaperones
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-392499 Metabolism of proteins
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-5653656 Vesicle-mediated transport
R-HSA-597592 Post-translational protein modification
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-948021 Transport to the Golgi and subsequent modification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002690 BXGD000124 Amputation Stumps
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0015469 BXGD000996 Facial paralysis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0015644 BXGD001008 Muscular fasciculation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0020649 BXGD001459 Hypotension Cardiovascular Diseases
C0023066 BXGD001605 Laryngospasm Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027498 BXGD001994 Nausea and vomiting Pathological Conditions, Signs and Symptoms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027868 BXGD002053 Neuromuscular Diseases Nervous System Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033790 BXGD002423 Pseudobulbar Palsy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0037315 BXGD002687 Sleep Apnea Syndromes Respiratory Tract Diseases; Nervous System Diseases
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037773 BXGD002704 Spastic Paraplegia, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0038868 BXGD002781 Progressive supranuclear palsy Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042928 BXGD003014 Vocal Cord Paralysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0043352 BXGD003045 Xerostomia Stomatognathic Diseases
C0085084 BXGD003121 Motor Neuron Disease Nervous System Diseases
C0085631 BXGD003214 Agitation Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085632 BXGD003215 Apathy Behavior and Behavior Mechanisms
C0085633 BXGD003216 Mood swings Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233522 BXGD004585 Inappropriate behavior Behavior and Behavior Mechanisms
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0236642 BXGD004815 Pick Disease of the Brain Nervous System Diseases; Mental Disorders
C0239830 BXGD004998 Hand muscle atrophy
C0239831 BXGD004999 Hand muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0240735 BXGD005052 Personality Change Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0241700 BXGD005108 Voice Fatigue Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0242423 BXGD005164 Ramsay Hunt Paralysis Syndrome Nervous System Diseases
C0268425 BXGD005943 Alstrom Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0270763 BXGD006099 Familial Motor Neuron Disease Nervous System Diseases
C0270764 BXGD006100 Motor Neuron Disease, Lower Nervous System Diseases
C0334121 BXGD006996 Inflammatory Myofibroblastic Tumor Pathological Conditions, Signs and Symptoms
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0349251 BXGD007897 Behavioral syndrome associated with physiological disturbance and physical factors Mental Disorders
C0424448 BXGD008529 Mask-like facies Nervous System Diseases
C0427065 BXGD008604 Distal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0522224 BXGD009198 Paralysed Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0541794 BXGD009262 Skeletal muscle atrophy
C0686353 BXGD009833 Muscular Dystrophies, Limb-Girdle Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0746674 BXGD010147 Generalized muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0751072 BXGD010312 Frontotemporal Lobar Degeneration Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0752097 BXGD010659 Autosomal Dominant Juvenile Parkinson Disease Nervous System Diseases
C0752098 BXGD010660 Autosomal Dominant Parkinsonism Nervous System Diseases
C0752100 BXGD010661 Autosomal Recessive Parkinsonism Nervous System Diseases
C0752101 BXGD010662 Parkinsonism, Experimental Nervous System Diseases
C0752104 BXGD010663 Familial Juvenile Parkinsonism Nervous System Diseases
C0752105 BXGD010664 Parkinsonism, Juvenile Nervous System Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0917801 BXGD011412 Sleeplessness Nervous System Diseases; Mental Disorders
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1514517 BXGD013205 Prostate Stromal Proliferation of Uncertain Malignant Potential
C1611743 BXGD013456 Familial (FPAH)
C1707544 BXGD013590 Cutaneous Fibrous Histiocytoma, Epithelioid Variant Neoplasms
C1836296 BXGD014105 Muscle Weakness Lower Limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1838681 BXGD014337 Rapidly progressive
C1843315 BXGD014573 Neuronopathy, Distal Hereditary Motor, Type Viib Nervous System Diseases
C1843369 BXGD014577 Vertical supranuclear gaze palsy
C1843505 BXGD014590 Degeneration of anterior horn cells Nervous System Diseases
C1846566 BXGD014829 Degeneration of the lateral corticospinal tracts
C1848736 BXGD014970 Distal amyotrophy
C1850808 BXGD015179 Miyoshi myopathy
C1850889 BXGD015185 MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2B Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1854494 BXGD015409 Slow progression
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
C1862941 BXGD016145 Amyotrophic Lateral Sclerosis, Sporadic Nutritional and Metabolic Diseases; Nervous System Diseases
C1865412 BXGD016326 Abnormal lower motor neuron morphology
C1868193 BXGD016493 PNEUMOTHORAX, PRIMARY SPONTANEOUS
C1868594 BXGD016511 Perry Syndrome Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms
C1868675 BXGD016520 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE Nervous System Diseases
C1963060 BXGD016679 Agitation, CTCAE 3.0
C3203358 BXGD018558 Hypoventilation Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C3805715 BXGD019484 Short stepped shuffling gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3805839 BXGD019490 Central hypoventilation Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C4011788 BXGD020116 Behavioral variant of frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C4016314 BXGD020306 AMYOTROPHIC LATERAL SCLEROSIS, SUSCEPTIBILITY TO
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4022587 BXGD020928 Fatigable weakness of respiratory muscles
C4022588 BXGD020929 Fatigable weakness of swallowing muscles
C4024896 BXGD021461 Motor neuron atrophy
C4522245 BXGD023076 Atypical Spitz Nevus
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4551973 BXGD023459 Miyoshi Muscular Dystrophy 1 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C4551993 BXGD023469 Amyotrophic Lateral Sclerosis, Familial Nutritional and Metabolic Diseases; Nervous System Diseases
C4552811 BXGD023526 Generalized Muscle Weakness, CTCAE
C4552855 BXGD023528 Agitation, CTCAE 5.0
C4553743 BXGD023548 Spasticity, CTCAE
C4749653 BXGD024065 Distal hereditary motor neuropathy type 7 Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein