Showing entry for Kinesin-like protein KIF1A


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013261
Protein NameKinesin-like protein KIF1A
Uniport IdQ12756
GeneKIF1A
Gene Id547
DomainDUF3694; FHA; KIF1B; Kinesin; Kinesin_assoc; PH
Pfam PF12473   PF00498   PF12423   PF00225   PF16183   PF00169  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008089 anterograde axonal transport
Biological Process GO:1990048 anterograde neuronal dense core vesicle transport
Biological Process GO:0030705 cytoskeleton-dependent intracellular transport
Biological Process GO:0099519 dense core granule cytoskeletal transport
Biological Process GO:0022027 interkinetic nuclear migration
Biological Process GO:0007018 microtubule-based movement
Biological Process GO:0098840 protein transport along microtubule
Biological Process GO:0060998 regulation of dendritic spine development
Biological Process GO:0061001 regulation of dendritic spine morphogenesis
Biological Process GO:1990049 retrograde neuronal dense core vesicle transport
Biological Process GO:0016192 vesicle-mediated transport
molecular function GO:0016887 ATPase activity
molecular function GO:0005524 ATP binding
molecular function GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed
molecular function GO:0042802 identical protein binding
molecular function GO:0008017 microtubule binding
molecular function GO:0003777 microtubule motor activity
molecular function GO:0003774 motor activity
cellular component GO:0030424 axon
cellular component GO:1904115 axon cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0030425 dendrite
cellular component GO:0098674 extrinsic component of neuronal dense core vesicle membrane
cellular component GO:0005871 kinesin complex
cellular component GO:0005874 microtubule
cellular component GO:0043025 neuronal cell body
cellular component GO:0098992 neuronal dense core vesicle
cellular component GO:0043005 neuron projection
cellular component GO:0098794 postsynapse
cellular component GO:0008021 synaptic vesicle
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-983189 Kinesins
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0003028 BXGD000170 Anhidrosis Skin and Connective Tissue Diseases
C0003886 BXGD000238 Arthrogryposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004158 BXGD000261 Athetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0009024 BXGD000578 Clonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013144 BXGD000800 Drowsiness Mental Disorders
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0020072 BXGD001357 Hereditary Sensory Autonomic Neuropathy, Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0024003 BXGD001726 Lordosis Musculoskeletal Diseases
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0030486 BXGD002229 Paraplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030578 BXGD002243 Paronychia Inflammation Infections; Skin and Connective Tissue Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0034152 BXGD002467 Henoch-Schoenlein Purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0034935 BXGD002497 Babinski Reflex
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0037771 BXGD002702 Paraparesis, Spastic Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037772 BXGD002703 Spastic Paraplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037773 BXGD002704 Spastic Paraplegia, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0041341 BXGD002918 Tuberous Sclerosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0085649 BXGD003222 Peripheral edema Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Cardiovascular Diseases
C0085996 BXGD003260 Child Development Deviations Mental Disorders
C0085997 BXGD003261 Child Development Disorders, Specific Mental Disorders
C0086692 BXGD003306 Benign Neoplasm Neoplasms
C0087012 BXGD003318 Ataxia, Spinocerebellar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0151313 BXGD003413 Sensory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151572 BXGD003442 Reflex, Corneal, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151860 BXGD003490 Acquired porencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151934 BXGD003504 Hypogeusia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152421 BXGD003586 Macrotia
C0162285 BXGD003928 Edema of eyelid Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases; Cardiovascular Diseases
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231687 BXGD004509 Spastic gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231698 BXGD004517 Gait, Scissors Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234162 BXGD004627 Cerebellar Dysmetria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234649 BXGD004692 Abnormal saccadic eye movement
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0238651 BXGD004951 Ankle clonus
C0240379 BXGD005033 Open mouth (finding)
C0259749 BXGD005216 Autonomic neuropathy Nervous System Diseases
C0266589 BXGD005698 Congenital ear anomaly NOS (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Otorhinolaryngologic Diseases
C0268119 BXGD005821 Combined molybdoflavoprotein enzyme deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0269269 BXGD006058 Inversion of nipple (disorder) Skin and Connective Tissue Diseases
C0270914 BXGD006131 Hereditary Motor and Sensory-Neuropathy Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270921 BXGD006133 Axonal neuropathy Nervous System Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0376480 BXGD007998 Gingival Overgrowth Stomatognathic Diseases
C0393556 BXGD008089 Complicated hereditary spastic paraplegia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0424503 BXGD008532 Dysmorphic facies
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0426886 BXGD008594 Tapering fingers (finding)
C0431370 BXGD008675 Atrophy of corpus callosum Nervous System Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0497202 BXGD009055 Abnormal ocular motility
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0541794 BXGD009262 Skeletal muscle atrophy
C0557874 BXGD009444 Global developmental delay
C0574002 BXGD009497 Edema of foot (finding) Pathological Conditions, Signs and Symptoms
C0596887 BXGD009648 mathematical ability
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0678230 BXGD009750 Congenital Epicanthus
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C0699739 BXGD009861 Sensory Neuropathy, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0742028 BXGD010051 Cerebellar vermis atrophy
C0751602 BXGD010520 Hereditary Autosomal Dominant Spastic Paraplegia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0917990 BXGD011424 Acro-Osteolysis Musculoskeletal Diseases
C1096063 BXGD011600 Drug Resistant Epilepsy Nervous System Diseases
C1112256 BXGD011655 Sensorimotor neuropathy
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1263857 BXGD011900 Peripheral axonal neuropathy Nervous System Diseases
C1271100 BXGD012007 Lower limb spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1833225 BXGD013904 Dystrophic toenail
C1835265 BXGD014022 Lymphedema, microcephaly and chorioretinopathy syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C1835896 BXGD014064 SPASTIC PARAPLEGIA 30, AUTOSOMAL RECESSIVE (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1836296 BXGD014105 Muscle Weakness Lower Limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836696 BXGD014151 Lower limb hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1837602 BXGD014250 Painless fractures due to injury
C1839630 BXGD014391 Severe muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1840077 BXGD014434 Anteverted nostril
C1843367 BXGD014576 Poor school performance
C1843663 BXGD014600 Urinary bladder sphincter dysfunction
C1846460 BXGD014820 Abnormality of the outer ear
C1847584 BXGD014876 Distal sensory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1848735 BXGD014969 Developmental delay, mild
C1848736 BXGD014970 Distal amyotrophy
C1849148 BXGD015014 Decreased sensory nerve conduction velocity
C1850055 BXGD015102 PEHO syndrome Eye Diseases; Nervous System Diseases
C1852289 BXGD015270 Autoamputation of digits Musculoskeletal Diseases
C1853242 BXGD015322 Midface retrusion
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1853761 BXGD015359 SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1854114 BXGD015383 Short nose
C1854418 BXGD015402 Biparietal narrowing
C1854465 BXGD015405 TUBEROUS SCLEROSIS 1 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C1854494 BXGD015409 Slow progression
C1854699 BXGD015425 Diffuse cerebellar atrophy
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1855483 BXGD015501 Progressive spastic paraplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1857108 BXGD015677 Limitation of joint mobility
C1857171 BXGD015680 Episodic hyperhidrosis Skin and Connective Tissue Diseases
C1857640 BXGD015726 Decreased nerve conduction velocity
C1858085 BXGD015770 Malar flattening
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858285 BXGD015781 Decreased number of peripheral myelinated nerve fibers
C1858712 BXGD015821 Spastic paraplegia 10, autosomal dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1860834 BXGD016006 Infantile muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1861403 BXGD016045 Variable expressivity
C1864929 BXGD016274 Cerebellar atrophy, progressive
C1866231 BXGD016388 Full cheeks
C2674432 BXGD017246 Reduced bone mineral density
C2674608 BXGD017250 Feeding difficulties in infancy
C2752089 BXGD017768 Neuropathy, Hereditary Sensory And Autonomic, Type IIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2830004 BXGD017804 Somnolence Pathological Conditions, Signs and Symptoms
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3161330 BXGD018511 Profound intellectual disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3278923 BXGD018748 Dilated ventricles (finding)
C3280168 BXGD018811 NEUROPATHY, HEREDITARY SENSORY, TYPE IIC
C3280283 BXGD018818 MENTAL RETARDATION, AUTOSOMAL DOMINANT 9
C3551426 BXGD019146 Dystrophic fingernails
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665386 BXGD019284 Abnormal vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C3887709 BXGD019918 Optic Neuropathy Eye Diseases; Nervous System Diseases
C3887898 BXGD019926 Infantile Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021611 BXGD020697 Abnormality of epiphysis morphology
C4021735 BXGD020743 Abnormality of the hip bone
C4021741 BXGD020749 Abnormal cortical bone morphology
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4021815 BXGD020801 Abnormal palate morphology
C4024610 BXGD021341 Leg muscle stiffness
C4024896 BXGD021461 Motor neuron atrophy
C4024900 BXGD021463 Atrophy/Degeneration affecting the brainstem
C4024921 BXGD021475 Lower limb amyotrophy
C4025660 BXGD021715 Abnormality of the ankles
C4025676 BXGD021727 Abnormality of the knee
C4025744 BXGD021771 Foot acroosteolysis
C4025884 BXGD021844 Abnormality of upper lip
C4048268 BXGD021896 Cortical visual impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4082169 BXGD022084 Metatarsus Varus Musculoskeletal Diseases
C4082172 BXGD022086 Porencephalic cyst
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4551492 BXGD023317 Micropenis
C4551563 BXGD023351 Microcephaly (physical finding)
C4551583 BXGD023361 Cerebral cortical atrophy
C4553743 BXGD023548 Spasticity, CTCAE
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4732740 BXGD023896 Acral ulceration
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein