Showing entry for Kinesin heavy chain isoform 5A


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013269
Protein NameKinesin heavy chain isoform 5A
Uniport IdQ12840
GeneKIF5A
Gene Id3798
DomainKinesin
Pfam PF00225  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
5. Organismal Systems 5.6 Nervous system hsa04728 Dopaminergic synapse
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0099641 anterograde axonal protein transport
Biological Process GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:0007411 axon guidance
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0030705 cytoskeleton-dependent intracellular transport
Biological Process GO:0007018 microtubule-based movement
Biological Process GO:1990049 retrograde neuronal dense core vesicle transport
Biological Process GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Biological Process GO:0048489 synaptic vesicle transport
Biological Process GO:0016192 vesicle-mediated transport
molecular function GO:0016887 ATPase activity
molecular function GO:0005524 ATP binding
molecular function GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed
molecular function GO:0019894 kinesin binding
molecular function GO:0008017 microtubule binding
molecular function GO:0003777 microtubule motor activity
molecular function GO:0003774 motor activity
cellular component GO:1904115 axon cytoplasm
cellular component GO:0035253 ciliary rootlet
cellular component GO:0005829 cytosol
cellular component GO:0032839 dendrite cytoplasm
cellular component GO:0005871 kinesin complex
cellular component GO:0016020 membrane
cellular component GO:0005874 microtubule
cellular component GO:0043204 perikaryon
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-199991 Membrane Trafficking
R-HSA-2132295 MHC class II antigen presentation
R-HSA-264876 Insulin processing
R-HSA-2980736 Peptide hormone metabolism
R-HSA-392499 Metabolism of proteins
R-HSA-5625970 RHO GTPases activate KTN1
R-HSA-5653656 Vesicle-mediated transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-983189 Kinesins
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0003872 BXGD000235 Arthritis, Psoriatic Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004158 BXGD000261 Athetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013312 BXGD000814 Dupuytren Contracture Neoplasms; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0013363 BXGD000818 Dysautonomia Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014550 BXGD000930 Myoclonic Epilepsy Nervous System Diseases
C0015644 BXGD001008 Muscular fasciculation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0023520 BXGD001678 Leukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0030232 BXGD002197 Pallor Pathological Conditions, Signs and Symptoms
C0030554 BXGD002239 Paresthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0034152 BXGD002467 Henoch-Schoenlein Purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0034935 BXGD002497 Babinski Reflex
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037771 BXGD002702 Paraparesis, Spastic Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037772 BXGD002703 Spastic Paraplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037773 BXGD002704 Spastic Paraplegia, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0042024 BXGD002949 Urinary Incontinence Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042345 BXGD002977 Varicosity Cardiovascular Diseases
C0085606 BXGD003201 Urgency of micturition Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231687 BXGD004509 Spastic gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0236642 BXGD004815 Pick Disease of the Brain Nervous System Diseases; Mental Disorders
C0238651 BXGD004951 Ankle clonus
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0264545 BXGD005400 Thickening of pleura Respiratory Tract Diseases
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0270914 BXGD006131 Hereditary Motor and Sensory-Neuropathy Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270921 BXGD006133 Axonal neuropathy Nervous System Diseases
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0339789 BXGD007282 Congenital deafness Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Nervous System Diseases; Otorhinolaryngologic Diseases
C0393555 BXGD008088 Pure hereditary spastic paraplegia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0431375 BXGD008677 Classical Lissencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0520823 BXGD009114 Patellar clonus
C0598589 BXGD009667 Inherited neuropathies Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751602 BXGD010520 Hereditary Autosomal Dominant Spastic Paraplegia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1112256 BXGD011655 Sensorimotor neuropathy
C1263857 BXGD011900 Peripheral axonal neuropathy Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1271100 BXGD012007 Lower limb spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1273957 BXGD012019 Upper limb spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1277241 BXGD012110 Delayed myelination Mental Disorders
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1836296 BXGD014105 Muscle Weakness Lower Limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836451 BXGD014118 Distal lower limb amyotrophy
C1836696 BXGD014151 Lower limb hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1836904 BXGD014176 Spastic/hyperactive bladder
C1843175 BXGD014563 Hyperreflexia in upper limbs Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1843663 BXGD014600 Urinary bladder sphincter dysfunction
C1846017 BXGD014776 Progressive pes cavus
C1847584 BXGD014876 Distal sensory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1848980 BXGD014993 Developmental stagnation
C1849134 BXGD015010 Impaired vibration sensation in the lower limbs
C1853767 BXGD015361 Impaired distal vibration sensation
C1855010 BXGD015450 Progressive leukoencephalopathy Nervous System Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858712 BXGD015821 Spastic paraplegia 10, autosomal dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2720436 BXGD017533 Fibrosis of pleura Infections; Respiratory Tract Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3642347 BXGD019246 Basal-Like Breast Carcinoma
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3810365 BXGD019652 Central visual impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021523 BXGD020650 Upper limb amyotrophy
C4024610 BXGD021341 Leg muscle stiffness
C4048268 BXGD021896 Cortical visual impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4310658 BXGD022616 MYOCLONUS, INTRACTABLE, NEONATAL
C4317123 BXGD022727 Myoclonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4553976 BXGD023554 Urinary Urgency, CTCAE 5
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4693609 BXGD023608 AMYOTROPHIC LATERAL SCLEROSIS, SUSCEPTIBILITY TO, 25
C4707173 BXGD023708 Autosomal dominant Charcot-Marie-Tooth disease type 2 due to KIF5A mutation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4732774 BXGD023899 Spastic paraparetic gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein