Showing entry for Egl nine homolog 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019688
Protein NameEgl nine homolog 2
Uniport IdQ96KS0
GeneEGLN2
Gene Id112398
Domain2OG-FeII_Oxy_3
Pfam PF13640  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04066 HIF-1 signaling pathway
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05211 Renal cell carcinoma
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0045454 cell redox homeostasis
Biological Process GO:0071456 cellular response to hypoxia
Biological Process GO:0030520 intracellular estrogen receptor signaling pathway
Biological Process GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
Biological Process GO:0045732 positive regulation of protein catabolic process
Biological Process GO:0001558 regulation of cell growth
Biological Process GO:0043523 regulation of neuron apoptotic process
Biological Process GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
Biological Process GO:0001666 response to hypoxia
molecular function GO:0016706 2-oxoglutarate-dependent dioxygenase activity
molecular function GO:0008198 ferrous iron binding
molecular function GO:0031418 L-ascorbic acid binding
molecular function GO:0019826 oxygen sensor activity
molecular function GO:0031545 peptidyl-proline 4-dioxygenase activity
molecular function GO:0031543 peptidyl-proline dioxygenase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1234174 Cellular response to hypoxia
R-HSA-1234174 Cellular response to hypoxia
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-2262752 Cellular responses to stress
R-HSA-2262752 Cellular responses to stress
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-8953897 Cellular responses to external stimuli
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011195 BXGD000702 Dejerine-Sottas Disease (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0017638 BXGD001132 Glioma Neoplasms
C0018935 BXGD001252 Hematocrit procedure
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023492 BXGD001671 Leukemia, T-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0030421 BXGD002218 Paraganglioma Neoplasms
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0032461 BXGD002356 Polycythemia Hemic and Lymphatic Diseases
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0039730 BXGD002826 Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0085859 BXGD003254 Polyglandular Type I Autoimmune Syndrome Immune System Diseases; Endocrine System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0155877 BXGD003830 Allergic asthma Respiratory Tract Diseases; Immune System Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0178468 BXGD004029 Autoimmune thyroid disease Immune System Diseases; Endocrine System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0266006 BXGD005603 Pili torti-deafness syndrome Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0346255 BXGD007805 Oncocytoma, renal Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376544 BXGD008001 Hematopoietic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0376620 BXGD008004 Pouchitis Digestive System Diseases
C0423319 BXGD008479 Atrophic iris Eye Diseases
C0518015 BXGD009068 Hemoglobin measurement
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751435 BXGD010440 Hyperphenylalaninaemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1134719 BXGD011688 Invasive Ductal Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1510502 BXGD013175 Oxyphilic Adenoma Neoplasms
C1519383 BXGD013237 Smoking Behaviors Behavior and Behavior Mechanisms
C1708353 BXGD013599 Hereditary Paraganglioma-Pheochromocytoma Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C1848296 BXGD014918 DOSAGE-SENSITIVE SEX REVERSAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1861063 BXGD016011 TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)
C2826323 BXGD017790 Refractory Cytopenia of Childhood
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3888194 BXGD019955 MIXED LINEAGE LEUKEMIA
C4551637 BXGD023379 Erythrocytosis familial, 1 Hemic and Lymphatic Diseases
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000764 L-Ascorbic acid 176.12
BXGC0002485 2-Oxopentanedioic acid 146.1
BXGC0004709 N-(2-Hydroxybenzoyl)glycine 195.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein