Showing entry for Natural resistance-associated macrophage protein 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010689
Protein NameNatural resistance-associated macrophage protein 2
Uniport IdP49281
GeneSLC11A2
Gene Id4891
DomainNramp
Pfam PF01566  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
4. Cellular Processes 4.2 Cell growth and death hsa04216 Ferroptosis
5. Organismal Systems 5.4 Digestive system hsa04978 Mineral absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0070574 cadmium ion transmembrane transport
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0006879 cellular iron ion homeostasis
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0006824 cobalt ion transport
Biological Process GO:0006825 copper ion transport
Biological Process GO:0048813 dendrite morphogenesis
Biological Process GO:0003032 detection of oxygen
Biological Process GO:0048821 erythrocyte development
Biological Process GO:0006783 heme biosynthetic process
Biological Process GO:0033212 iron import into cell
Biological Process GO:0034755 iron ion transmembrane transport
Biological Process GO:0006826 iron ion transport
Biological Process GO:0015692 lead ion transport
Biological Process GO:0007611 learning or memory
Biological Process GO:0006828 manganese ion transport
Biological Process GO:0060586 multicellular organismal iron ion homeostasis
Biological Process GO:0015675 nickel cation transport
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0010039 response to iron ion
Biological Process GO:0015676 vanadium ion transport
Biological Process GO:0071577 zinc ion transmembrane transport
molecular function GO:0046870 cadmium ion binding
molecular function GO:0015086 cadmium ion transmembrane transporter activity
molecular function GO:0015087 cobalt ion transmembrane transporter activity
molecular function GO:0005375 copper ion transmembrane transporter activity
molecular function GO:0015093 ferrous iron transmembrane transporter activity
molecular function GO:0022890 inorganic cation transmembrane transporter activity
molecular function GO:0005381 iron ion transmembrane transporter activity
molecular function GO:0015094 lead ion transmembrane transporter activity
molecular function GO:0005384 manganese ion transmembrane transporter activity
molecular function GO:0015099 nickel cation transmembrane transporter activity
molecular function GO:1905394 retromer complex binding
molecular function GO:0015295 solute:proton symporter activity
molecular function GO:0046915 transition metal ion transmembrane transporter activity
molecular function GO:0015100 vanadium ion transmembrane transporter activity
molecular function GO:0005385 zinc ion transmembrane transporter activity
cellular component GO:0045177 apical part of cell
cellular component GO:0016324 apical plasma membrane
cellular component GO:0045178 basal part of cell
cellular component GO:0031526 brush border membrane
cellular component GO:0009986 cell surface
cellular component GO:0005737 cytoplasm
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005769 early endosome
cellular component GO:1903561 extracellular vesicle
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005770 late endosome
cellular component GO:0031902 late endosome membrane
cellular component GO:0005765 lysosomal membrane
cellular component GO:0005764 lysosome
cellular component GO:0016020 membrane
cellular component GO:0005741 mitochondrial outer membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0005634 nucleus
cellular component GO:0070826 paraferritin complex
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0055037 recycling endosome
cellular component GO:0005802 trans-Golgi network
cellular component GO:0005773 vacuole
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-382551 Transport of small molecules
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-425410 Metal ion SLC transporters
R-HSA-5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)
R-HSA-5619102 SLC transporter disorders
R-HSA-5619115 Disorders of transmembrane transporters
R-HSA-917937 Iron uptake and transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001857 BXGD000085 AIDS related complex Infections; Immune System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002884 BXGD000143 Hypochromic anemia Hemic and Lymphatic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003949 BXGD000242 Asbestosis Respiratory Tract Diseases; Occupational Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010474 BXGD000672 Curling Ulcer Digestive System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013295 BXGD000812 Duodenal Ulcer Digestive System Diseases
C0018995 BXGD001265 Hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0019202 BXGD001302 Hepatolenticular Degeneration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029810 BXGD002172 Other specified iron deficiency anemias Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0035258 BXGD002523 Restless Legs Syndrome Nervous System Diseases; Mental Disorders
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039730 BXGD002826 Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041956 BXGD002942 Ureteral obstruction Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042961 BXGD003017 Intestinal Volvulus Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0085576 BXGD003188 Iron-Refractory Iron Deficiency Anemia Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0162309 BXGD003934 Adrenoleukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0162316 BXGD003936 Iron deficiency anemia Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0235833 BXGD004775 Congenital diaphragmatic hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0240066 BXGD005016 Iron deficiency Nutritional and Metabolic Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0271901 BXGD006277 Microcytic hypochromic anemia (disorder) Hemic and Lymphatic Diseases
C0282193 BXGD006798 Iron Overload Nutritional and Metabolic Diseases
C0302486 BXGD006847 Erythrophagocytosis
C0333912 BXGD006973 Hypochromatism
C0342637 BXGD007517 Hypocalciuric hypercalcemia, familial, type 1 Nutritional and Metabolic Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0392514 BXGD008051 Hereditary hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0392557 BXGD008056 Nuclear cataract Eye Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0855790 BXGD011088 Decreased mean corpuscular volume
C0856169 BXGD011096 Endothelial dysfunction
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948120 BXGD011507 Hepatic siderosis Nutritional and Metabolic Diseases
C1112705 BXGD011681 Nuclear non-senile cataract Eye Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1833296 BXGD013909 FRONTOTEMPORAL DEMENTIA, CHROMOSOME 3-LINKED Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C1868594 BXGD016511 Perry Syndrome Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2673913 BXGD017231 Anemia, Hypochromic Microcytic, With Iron Overload Hemic and Lymphatic Diseases
C2827503 BXGD017799 HFE-Associated Hereditary Hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3160718 BXGD018468 PARKINSON DISEASE, LATE-ONSET
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3469186 BXGD018909 HEMOCHROMATOSIS, TYPE 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3550973 BXGD019143 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 5 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3806153 BXGD019496 ANEMIA, HYPOCHROMIC MICROCYTIC, WITH IRON OVERLOAD 1
C3826102 BXGD019712 Iron deficiency anemia in children
C3844293 BXGD019807 Oval fat body
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4021780 BXGD020775 Abnormality of the liver
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4529962 BXGD023178 Fatty Liver Disease
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0038991 Selenomethionine 197
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein