Showing entry for 6-phosphogluconate dehydrogenase, decarboxylating


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010923
Protein Name6-phosphogluconate dehydrogenase, decarboxylating
Uniport IdP52209
GenePGD
Gene Id5226
Domain6PGD; NAD_binding_2
Pfam PF00393   PF03446  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00030 Pentose phosphate pathway
1. Metabolism 1.6 Metabolism of other amino acids hsa00480 Glutathione metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0046177 D-gluconate catabolic process
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0019322 pentose biosynthetic process
Biological Process GO:0006098 pentose-phosphate shunt
Biological Process GO:0009051 pentose-phosphate shunt, oxidative branch
molecular function GO:0050661 NADP binding
molecular function GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-71336 Pentose phosphate pathway
R-HSA-71387 Metabolism of carbohydrates
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002312 BXGD000107 alpha-Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002875 BXGD000135 Cooley's anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004509 BXGD000275 Azoospermia Male Urogenital Diseases
C0005283 BXGD000308 beta Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013377 BXGD000825 Dysgerminoma Neoplasms
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0016667 BXGD001072 Fragile X Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0018055 BXGD001169 Gonadal Dysgenesis, Mixed Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0018987 BXGD001262 Hemimelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0023264 BXGD001625 Leigh Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023283 BXGD001629 Leishmaniasis, Cutaneous Infections; Skin and Connective Tissue Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0024530 BXGD001783 Malaria Infections
C0024537 BXGD001786 Malaria, Vivax Infections
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027126 BXGD001976 Myotonic Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027831 BXGD002047 Neurofibromatosis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0033844 BXGD002435 Pseudotumor Pathological Conditions, Signs and Symptoms
C0036631 BXGD002626 Seminoma Neoplasms
C0039730 BXGD002826 Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0041408 BXGD002923 Turner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0042900 BXGD003012 Vitiligo Skin and Connective Tissue Diseases
C0085413 BXGD003171 Polycystic Kidney, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0154208 BXGD003707 Disorder of endocrine ovary Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0206661 BXGD004224 Gonadoblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0220810 BXGD004346 Congenital defects
C0234935 BXGD004701 Acute urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0238461 BXGD004936 Anaplastic thyroid carcinoma Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0266360 BXGD005655 Streak gonad Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0266362 BXGD005657 Ambiguous Genitalia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0333693 BXGD006964 Triploidy syndrome Pathological Conditions, Signs and Symptoms
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0406305 BXGD008333 Eosinophilic pustular folliculitis Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0687149 BXGD009841 Pure gonadal dysgenesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0815107 BXGD010861 psychological distress
C0917796 BXGD011408 Optic Atrophy, Hereditary, Leber Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C0936016 BXGD011475 Testicular Feminization Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0948444 BXGD011539 Mitochondrial DNA mutation
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1456873 BXGD013129 alpha^+^ Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1846357 BXGD014806 Meckel syndrome type 3 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1847835 BXGD014892 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) Skin and Connective Tissue Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2242796 BXGD017002 Sickle cell-thalassemia disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C2717865 BXGD017513 Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Immune System Diseases; Cardiovascular Diseases
C2751898 BXGD017749 Ventricular Fibrillation, Paroxysmal Familial, 1 Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2936694 BXGD018127 Swyer Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3841475 BXGD019800 beta^+^ Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C4040907 BXGD021872 Mosaic Turner syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases; Cardiovascular Diseases
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4552766 BXGD023523 Miscarriage Female Urogenital Diseases and Pregnancy Complications
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000019 ent-Gallocatechin 3-gallate 458.37
BXGC0002690 alpha-Catechin 290.27
BXGC0003008 4-Gallocatechol 306.27
BXGC0003705 Chloride 35.45
BXGC0009209 Epicatechin 3-gallate 442.38
BXGC0009548 Epigallocatechin 306.27
BXGC0020098 (-)-Catechin 290.08
BXGC0033310 Epigalocatechin Gallate 458.08
BXGC0038705 (-)-Catechingallate 442.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein