Showing entry for Isobutyryl-CoA dehydrogenase, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021749
Protein NameIsobutyryl-CoA dehydrogenase, mitochondrial
Uniport IdQ9UKU7
GeneACAD8
Gene Id27034
DomainAcyl-CoA_dh_1; Acyl-CoA_dh_M; Acyl-CoA_dh_N
Pfam PF00441   PF02770   PF02771  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00280 Valine, leucine and isoleucine degradation
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009083 branched-chain amino acid catabolic process
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0006574 valine catabolic process
molecular function GO:0003995 acyl-CoA dehydrogenase activity
molecular function GO:0050660 flavin adenine dinucleotide binding
cellular component GO:0005759 mitochondrial matrix
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-70895 Branched-chain amino acid catabolism
R-HSA-71291 Metabolism of amino acids and derivatives
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0001430 BXGD000054 Adenoma Neoplasms
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003615 BXGD000212 Appendicitis Digestive System Diseases; Infections
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003872 BXGD000235 Arthritis, Psoriatic Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0008313 BXGD000528 Cholangitis, Sclerosing Digestive System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009376 BXGD000603 Colonic Polyps Pathological Conditions, Signs and Symptoms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0012813 BXGD000791 Diverticulitis Digestive System Diseases
C0014356 BXGD000910 Enterocolitis Digestive System Diseases
C0014743 BXGD000946 Erythema Nodosum Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0017160 BXGD001099 Gastroenteritis Digestive System Diseases
C0017178 BXGD001102 Gastrointestinal Diseases Digestive System Diseases
C0018203 BXGD001184 Chronic granulomatous disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0018553 BXGD001203 Hamartoma Syndrome, Multiple Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0019112 BXGD001286 Hemorrhoids Digestive System Diseases; Cardiovascular Diseases
C0019214 BXGD001307 Hepatosplenomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Hemic and Lymphatic Diseases
C0020981 BXGD001474 Angioimmunoblastic Lymphadenopathy Immune System Diseases; Hemic and Lymphatic Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021167 BXGD001487 Incontinence Nervous System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021831 BXGD001516 Intestinal Diseases Digestive System Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0022408 BXGD001544 Arthropathy Musculoskeletal Diseases
C0023343 BXGD001635 Leprosy Infections
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0024314 BXGD001767 Lymphoproliferative Disorders Immune System Diseases; Hemic and Lymphatic Diseases
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0024793 BXGD001805 Marek Disease Infections; Immune System Diseases; Hemic and Lymphatic Diseases; Animal Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026946 BXGD001951 Mycoses Infections
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029400 BXGD002134 Osteitis Musculoskeletal Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030354 BXGD002214 Papilloma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031019 BXGD002267 Perianal abscess Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Infections; Skin and Connective Tissue Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035288 BXGD002524 Reticuloendotheliosis, X-linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0035435 BXGD002549 Rheumatism Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037285 BXGD002680 Skin Manifestations Pathological Conditions, Signs and Symptoms
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0038443 BXGD002757 Stress, Psychological Behavior and Behavior Mechanisms
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040147 BXGD002847 Thyroiditis Endocrine System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042164 BXGD002965 Uveitis Eye Diseases
C0042870 BXGD003008 Vitamin D Deficiency Nutritional and Metabolic Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085652 BXGD003224 Pyoderma Gangrenosum Skin and Connective Tissue Diseases
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151594 BXGD003444 Hemorrhagic diarrhea Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0155773 BXGD003820 Portal Vein Thrombosis Cardiovascular Diseases
C0156147 BXGD003838 Crohn's disease of large bowel Digestive System Diseases
C0156173 BXGD003840 Functional diarrhea Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0162316 BXGD003936 Iron deficiency anemia Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0162836 BXGD003990 Hidradenitis Suppurativa Infections; Skin and Connective Tissue Diseases
C0175694 BXGD004002 Smith-Lemli-Opitz Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0221757 BXGD004472 alpha 1-Antitrypsin Deficiency Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0235874 BXGD004781 Disease Exacerbation Pathological Conditions, Signs and Symptoms
C0238067 BXGD004870 Colitis, Collagenous Digestive System Diseases
C0238106 BXGD004876 Clostridium difficile colitis Digestive System Diseases; Infections
C0240066 BXGD005016 Iron deficiency Nutritional and Metabolic Diseases
C0242172 BXGD005138 Pelvic Inflammatory Disease Female Urogenital Diseases and Pregnancy Complications; Infections
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0242490 BXGD005171 Enthesopathy Musculoskeletal Diseases; Wounds and Injuries
C0242510 BXGD005173 Drug usage Chemically-Induced Disorders; Mental Disorders
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0263680 BXGD005344 Chronic arthritis Musculoskeletal Diseases
C0263888 BXGD005353 Back disorder Musculoskeletal Diseases
C0267375 BXGD005742 Chronic colitis Digestive System Diseases
C0267430 BXGD005748 Noninfectious colitis Digestive System Diseases
C0271713 BXGD006247 Ketotic hypoglycemia Nutritional and Metabolic Diseases
C0279068 BXGD006624 Childhood Solid Neoplasm
C0280099 BXGD006712 Adult Solid Neoplasm
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0332853 BXGD006901 Anastomosis
C0338908 BXGD007218 Mixed anxiety and depressive disorder Mental Disorders
C0341106 BXGD007389 Eosinophilic esophagitis Digestive System Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0341332 BXGD007403 Indeterminate colitis Digestive System Diseases
C0342783 BXGD007550 Deficiency of butyryl-CoA dehydrogenase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0342970 BXGD007589 Increased oxygen demand
C0343386 BXGD007620 Clostridium difficile infection Infections
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0345903 BXGD007744 Anal skin tag Skin and Connective Tissue Diseases
C0347129 BXGD007848 Dysplasia of anus Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0376620 BXGD008004 Pouchitis Digestive System Diseases
C0394006 BXGD008166 Dysequilibrium syndrome Nervous System Diseases
C0398623 BXGD008202 Thrombophilia Hemic and Lymphatic Diseases
C0398686 BXGD008215 Primary immune deficiency disorder Immune System Diseases
C0400821 BXGD008257 Colitis, Microscopic Digestive System Diseases
C0400936 BXGD008264 Autoimmune liver disease Digestive System Diseases; Immune System Diseases
C0406740 BXGD008368 Kohlschutter Tonz syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Stomatognathic Diseases
C0426576 BXGD008571 Gastrointestinal symptom Pathological Conditions, Signs and Symptoms
C0432306 BXGD008770 Ichthyosis Bullosa of Siemens Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0549622 BXGD009392 Sexual Dysfunction Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Mental Disorders; Behavior and Behavior Mechanisms
C0559031 BXGD009464 Functional Gastrointestinal Disorders Digestive System Diseases
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0685938 BXGD009829 Malignant neoplasm of gastrointestinal tract Digestive System Diseases; Neoplasms
C0687720 BXGD009844 Central Diabetes Insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0701807 BXGD009901 Acute anterior uveitis Eye Diseases
C0740277 BXGD009972 Bile duct carcinoma Digestive System Diseases; Neoplasms
C0747845 BXGD010184 early pregnancy
C0751771 BXGD010582 Sleep Bruxism Nervous System Diseases; Mental Disorders; Stomatognathic Diseases
C0815107 BXGD010861 psychological distress
C0849888 BXGD010893 psychological disturbance
C0850666 BXGD010901 Infection caused by Helicobacter pylori Infections
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0858617 BXGD011183 Posterior subcapsular cataract Eye Diseases
C0949690 BXGD011584 Spondylarthritis Musculoskeletal Diseases
C1112574 BXGD011678 Granulomatous ileocolitis
C1142132 BXGD011733 Carnitine deficiency
C1257843 BXGD011810 pseudomembranous colitis Digestive System Diseases; Infections
C1282952 BXGD012153 Enthesitis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases; Wounds and Injuries
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1290886 BXGD012200 Chronic inflammatory disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1321275 BXGD012428 Non-specific colitis Digestive System Diseases
C1321898 BXGD012449 Blood in stool Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C1332259 BXGD012517 Adenocarcinoma of anal canal Digestive System Diseases; Neoplasms
C1332262 BXGD012518 Anal canal squamous cell carcinoma Digestive System Diseases; Neoplasms
C1333110 BXGD012596 Colorectal High Grade Intraepithelial Neoplasia
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1561826 BXGD013364 Overweight and obesity
C1611743 BXGD013456 Familial (FPAH)
C1704330 BXGD013548 Dental Diseases Stomatognathic Diseases
C1708349 BXGD013597 Hereditary Diffuse Gastric Cancer Digestive System Diseases; Neoplasms
C1841972 BXGD014484 Glucocorticoid Receptor Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1845076 BXGD014708 Lymphoproliferative Syndrome, X-Linked, 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C1856432 BXGD015605 Dicarboxylic aciduria
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1956257 BXGD016623 Pulmonary Stenosis Cardiovascular Diseases
C1969809 BXGD016796 Isobutyryl-CoA dehydrogenase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2362324 BXGD017091 Pediatric Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C2751532 BXGD017722 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2919828 BXGD017881 Chronic ulcerative colitis Digestive System Diseases
C2931133 BXGD017964 Pediatric Crohn's disease Digestive System Diseases
C2931173 BXGD017968 Pediatric ulcerative colitis Digestive System Diseases
C3160814 BXGD018477 Cannabis use
C3179455 BXGD018552 Niemann-Pick Disease, Type C1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3266731 BXGD018602 2-methyl-3-hydroxybutyric aciduria Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3272841 BXGD018637 MUTYH-Associate Polyposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C3281160 BXGD018885 EHLERS-DANLOS SYNDROME, KYPHOSCOLIOTIC TYPE, 2
C3468041 BXGD018905 FANCONI ANEMIA, COMPLEMENTATION GROUP C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3544347 BXGD019116 Intestinal fibrosis
C3696376 BXGD019346 3-Methylglutaconic Aciduria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3887638 BXGD019906 Failure to thrive in infant Pathological Conditions, Signs and Symptoms
C4012968 BXGD020124 Mild global developmental delay
C4048329 BXGD021904 Immunosuppression
C4073171 BXGD022059 Elevated plasma acylcarnitine levels
C4317045 BXGD022719 Gluten intolerance
C4324621 BXGD022774 Opioid use disorder
C4479344 BXGD022934 SCLEROSING CHOLANGITIS, NEONATAL
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004277 Acetic acid 60.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein