Showing entry for 40S ribosomal protein S6


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011454
Protein Name40S ribosomal protein S6
Uniport IdP62753
GeneRPS6
Gene Id6194
DomainRibosomal_S6e
Pfam PF01092  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01521 EGFR tyrosine kinase inhibitor resistance
2. Genetic Information Processing 2.2 Translation hsa03010 Ribosome
3. Environmental Information Processing 3.2 Signal transduction hsa04066 HIF-1 signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04150 mTOR signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006924 activation-induced cell death of T cells
Biological Process GO:0048821 erythrocyte development
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
Biological Process GO:0007369 gastrulation
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0022605 mammalian oogenesis stage
Biological Process GO:0007093 mitotic cell cycle checkpoint
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Process GO:0001890 placenta development
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0042274 ribosomal small subunit biogenesis
Biological Process GO:0006364 rRNA processing
Biological Process GO:0006614 SRP-dependent cotranslational protein targeting to membrane
Biological Process GO:0033077 T cell differentiation in thymus
Biological Process GO:0002309 T cell proliferation involved in immune response
Biological Process GO:0031929 TOR signaling
Biological Process GO:0006412 translation
Biological Process GO:0006413 translational initiation
Biological Process GO:0019083 viral transcription
molecular function GO:0019901 protein kinase binding
molecular function GO:0003723 RNA binding
molecular function GO:0003735 structural constituent of ribosome
cellular component GO:0044297 cell body
cellular component GO:0036464 cytoplasmic ribonucleoprotein granule
cellular component GO:0005829 cytosol
cellular component GO:0022627 cytosolic small ribosomal subunit
cellular component GO:0030425 dendrite
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0016020 membrane
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005844 polysome
cellular component GO:1990904 ribonucleoprotein complex
cellular component GO:0015935 small ribosomal subunit
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1430728 Metabolism
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156842 Eukaryotic Translation Elongation
R-HSA-156902 Peptide chain elongation
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-165159 MTOR signalling
R-HSA-166208 mTORC1-mediated signalling
R-HSA-168255 Influenza Infection
R-HSA-168273 Influenza Viral RNA Transcription and Replication
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2262752 Cellular responses to stress
R-HSA-2408522 Selenoamino acid metabolism
R-HSA-2408557 Selenocysteine synthesis
R-HSA-376176 Signaling by ROBO receptors
R-HSA-392499 Metabolism of proteins
R-HSA-392499 Metabolism of proteins
R-HSA-422475 Axon guidance
R-HSA-5663205 Infectious disease
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-72312 rRNA processing
R-HSA-72312 rRNA processing
R-HSA-72613 Eukaryotic Translation Initiation
R-HSA-72649 Translation initiation complex formation
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72737 Cap-dependent Translation Initiation
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-72766 Translation
R-HSA-72766 Translation
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-8953854 Metabolism of RNA
R-HSA-8953854 Metabolism of RNA
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-927802 Nonsense-Mediated Decay (NMD)
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-9675108 Nervous system development
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004114 BXGD000255 Astrocytoma Neoplasms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011263 BXGD000707 Multi-infarct dementia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Cardiovascular Diseases
C0011269 BXGD000710 Dementia, Vascular Nervous System Diseases; Mental Disorders; Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018923 BXGD001248 Hemangiosarcoma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022283 BXGD001533 Incontinentia Pigmenti Achromians Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0022665 BXGD001573 Kidney Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023281 BXGD001628 Leishmaniasis Infections; Skin and Connective Tissue Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023532 BXGD001685 Leukoplakia, Oral Pathological Conditions, Signs and Symptoms; Neoplasms; Stomatognathic Diseases
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027668 BXGD002019 Neoplasms, Vascular Tissue Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0040100 BXGD002840 Thymoma Neoplasms; Hemic and Lymphatic Diseases
C0040580 BXGD002877 Tracheal Diseases Respiratory Tract Diseases
C0041341 BXGD002918 Tuberous Sclerosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085084 BXGD003121 Motor Neuron Disease Nervous System Diseases
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0206180 BXGD004170 Ki-1+ Anaplastic Large Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0206633 BXGD004198 Angiomyolipoma Neoplasms
C0206731 BXGD004276 Angiofibroma Neoplasms
C0206733 BXGD004278 Strawberry nevus of skin Neoplasms
C0220605 BXGD004294 Adult Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220612 BXGD004296 Childhood Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0221505 BXGD004466 Lesion of brain
C0235874 BXGD004781 Disease Exacerbation Pathological Conditions, Signs and Symptoms
C0241961 BXGD005128 Angiomyolipoma of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0242852 BXGD005197 Proliferative vitreoretinopathy Eye Diseases
C0265008 BXGD005447 Aortocaval fistula Cardiovascular Diseases
C0265252 BXGD005483 Coffin-Lowry syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0278592 BXGD006544 Adult Angiosarcoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0279988 BXGD006707 Childhood Angiosarcoma Neoplasms
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0349566 BXGD007928 Squamous cell carcinoma of tongue Neoplasms; Stomatognathic Diseases
C0349649 BXGD007945 Pulmonary lymphangioleiomyomatosis Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0403367 BXGD008275 proliferative nephritis unspecified Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0431391 BXGD008683 Hemimegalencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0751674 BXGD010547 Lymphangioleiomyomatosis Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0751690 BXGD010553 Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0872084 BXGD011319 Sarcopenia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1096063 BXGD011600 Drug Resistant Epilepsy Nervous System Diseases
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1445957 BXGD013081 Serum total cholesterol measurement
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1562113 BXGD013372 Fleck corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1699634 BXGD013522 HER-2 positive breast cancer
C1708349 BXGD013597 Hereditary Diffuse Gastric Cancer Digestive System Diseases; Neoplasms
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1860707 BXGD015993 TUBEROUS SCLEROSIS 2 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C1960398 BXGD016658 HER2-positive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4087316 BXGD022142 Muscle hypoxia
C4317089 BXGD022721 Infantile hemangioma Neoplasms; Cardiovascular Diseases
C4522181 BXGD023074 Brachial Amyotrophic Diplegia Nervous System Diseases
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4721413 BXGD023737 Juvenile angiofibroma Neoplasms; Cardiovascular Diseases
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721532 BXGD023752 Lymphoma, Non-Hodgkin, Familial Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0018948 perillyl alcohol 152.12
BXGC0051100 dihydroartemisinin 284.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein