Showing entry for Probable ATP-dependent RNA helicase DDX58


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005396
Protein NameProbable ATP-dependent RNA helicase DDX58
Uniport IdO95786
GeneDDX58
Gene Id23586
DomainCARD_2; DEAD; Helicase_C; RIG-I_C; RIG-I_C-RD
Pfam PF16739   PF00270   PF00271   PF18119   PF11648  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04064 NF-kappa B signaling pathway
5. Organismal Systems 5.1 Immune system hsa04622 RIG-I-like receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04623 Cytosolic DNA-sensing pathway
6. Human Diseases 6.9 Infectious diseases: Viral hsa05160 Hepatitis C
6. Human Diseases 6.9 Infectious diseases: Viral hsa05161 Hepatitis B
6. Human Diseases 6.9 Infectious diseases: Viral hsa05162 Measles
6. Human Diseases 6.9 Infectious diseases: Viral hsa05164 Influenza A
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05169 Epstein-Barr virus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0140374 antiviral innate immune response
Biological Process GO:0071360 cellular response to exogenous dsRNA
Biological Process GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus
Biological Process GO:0051607 defense response to virus
Biological Process GO:0009597 detection of virus
Biological Process GO:0045087 innate immune response
Biological Process GO:0032480 negative regulation of type I interferon production
Biological Process GO:0002230 positive regulation of defense response to virus by host
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
Biological Process GO:0032727 positive regulation of interferon-alpha production
Biological Process GO:0032728 positive regulation of interferon-beta production
Biological Process GO:0032755 positive regulation of interleukin-6 production
Biological Process GO:0032757 positive regulation of interleukin-8 production
Biological Process GO:0002735 positive regulation of myeloid dendritic cell cytokine production
Biological Process GO:0060760 positive regulation of response to cytokine stimulus
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:1904469 positive regulation of tumor necrosis factor secretion
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0034344 regulation of type III interferon production
Biological Process GO:0043330 response to exogenous dsRNA
Biological Process GO:0009615 response to virus
Biological Process GO:0039529 RIG-I signaling pathway
Biological Process GO:0016032 viral process
molecular function GO:0005524 ATP binding
molecular function GO:0003690 double-stranded DNA binding
molecular function GO:0003725 double-stranded RNA binding
molecular function GO:0042802 identical protein binding
molecular function GO:0003724 RNA helicase activity
molecular function GO:0003727 single-stranded RNA binding
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0005923 bicellular tight junction
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005886 plasma membrane
cellular component GO:1990904 ribonucleoprotein complex
cellular component GO:0032587 ruffle membrane
Reactome
Pathway Id Pathway Name
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168249 Innate Immune System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-392499 Metabolism of proteins
R-HSA-5688426 Deubiquitination
R-HSA-5689880 Ub-specific processing proteases
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-597592 Post-translational protein modification
R-HSA-8983711 OAS antiviral response
R-HSA-913531 Interferon Signaling
R-HSA-918233 TRAF3-dependent IRF activation pathway
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-933542 TRAF6 mediated NF-kB activation
R-HSA-933542 TRAF6 mediated NF-kB activation
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001883 BXGD000086 Airway Obstruction Respiratory Tract Diseases
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0008055 BXGD000514 Chikungunya Fever Infections
C0008495 BXGD000548 Chorioamnionitis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011311 BXGD000714 Dengue Fever Infections
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011633 BXGD000742 Dermatomyositis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0014057 BXGD000880 Japanese Encephalitis Infections; Nervous System Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0018572 BXGD001206 Hand, Foot and Mouth Disease Infections
C0019097 BXGD001281 Hemorrhagic Fever, Argentinian Infections
C0019100 BXGD001283 Severe Dengue Infections
C0019104 BXGD001285 Hemorrhagic Fevers, Viral Infections
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025007 BXGD001821 Measles Infections
C0025202 BXGD001832 melanoma Neoplasms
C0025205 BXGD001833 Melanoma, Experimental Neoplasms
C0025309 BXGD001860 Meningoencephalitis Infections; Nervous System Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026896 BXGD001946 Myasthenia Gravis Neoplasms; Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029227 BXGD002123 Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030246 BXGD002198 Pustulosis of Palms and Soles Skin and Connective Tissue Diseases
C0032463 BXGD002357 Polycythemia Vera Neoplasms; Hemic and Lymphatic Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035235 BXGD002519 Respiratory Syncytial Virus Infections Infections
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0035920 BXGD002570 Rubella Infections
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0038826 BXGD002779 Superinfection Infections
C0040100 BXGD002840 Thymoma Neoplasms; Hemic and Lymphatic Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042769 BXGD002999 Virus Diseases Infections
C0043124 BXGD003031 West Nile Fever Infections; Nervous System Diseases
C0085293 BXGD003154 Hepatitis E Digestive System Diseases; Infections
C0085655 BXGD003226 Polymyositis Musculoskeletal Diseases; Nervous System Diseases
C0149678 BXGD003346 Epstein-Barr Virus Infections Infections
C0151449 BXGD003419 Primary Sjögren's syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0152268 BXGD003580 Nodular Sclerosis Classical Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205671 BXGD004104 Infections, Arenavirus Infections
C0220756 BXGD004338 Niemann-Pick Disease, Type C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0221056 BXGD004383 Adult type dermatomyositis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0235874 BXGD004781 Disease Exacerbation Pathological Conditions, Signs and Symptoms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238190 BXGD004890 Inclusion Body Myositis (disorder) Musculoskeletal Diseases; Nervous System Diseases
C0243010 BXGD005209 Viral Encephalitis Infections; Nervous System Diseases
C0266999 BXGD005725 Vesicular Stomatitis Infections; Stomatognathic Diseases; Animal Diseases
C0276289 BXGD006418 Zika Virus Infection Infections
C0276447 BXGD006425 Rhinovirus infection Infections
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279541 BXGD006629 Adult Nodular Sclerosis Classical Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0279921 BXGD006699 Childhood Nodular Sclerosis Classic Hodgkin Lymphoma
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0282687 BXGD006826 Hemorrhagic Fever, Ebola Infections
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0393591 BXGD008102 AICARDI-GOUTIERES SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Nervous System Diseases
C0432254 BXGD008757 Singleton Merten syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0524909 BXGD009247 Hepatitis B, Chronic Digestive System Diseases; Infections
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0795864 BXGD010754 Smith-Magenis syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0858004 BXGD011168 Influenza A virus infection Infections; Respiratory Tract Diseases
C0858005 BXGD011169 Influenza B virus infection Infections; Respiratory Tract Diseases
C0867389 BXGD011300 Chronic graft-versus-host disease Immune System Diseases
C0870082 BXGD011309 Hyperkeratosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948192 BXGD011514 Primary infection NOS
C1096184 BXGD011607 West Nile viral infection Infections; Nervous System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1318881 BXGD012406 Vancomycin intermediate staphylococcus aureus infection
C1319860 BXGD012419 Sendai virus infection Infections
C1333064 BXGD012587 Classical Hodgkin's Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1609538 BXGD013444 Latent Tuberculosis Infections
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1840264 BXGD014439 IMMUNE SUPPRESSION
C1853926 BXGD015365 NONAKA MYOPATHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1861453 BXGD016049 Pseudohyperkalemia Cardiff Nutritional and Metabolic Diseases
C2062441 BXGD016897 Influenza A
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347747 BXGD017040 Adult Classical Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2363741 BXGD017100 HIV-1 infection
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2748361 BXGD017588 H5N1 influenza
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C3264382 BXGD018591 Swine influenza virus (viruses that normally cause infections in pigs)
C3665444 BXGD019288 Neutrophilia (disorder) Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C3694279 BXGD019338 Middle East Respiratory Syndrome Infections
C3714514 BXGD019409 Infection Infections
C3875321 BXGD019874 Inflammatory dermatosis Skin and Connective Tissue Diseases
C4021790 BXGD020782 Abnormality of the skeletal system
C4041080 BXGD021873 Neurocognitive Disorders Mental Disorders
C4225380 BXGD022253 SINGLETON-MERTEN SYNDROME 2
C4225427 BXGD022277 SINGLETON-MERTEN SYNDROME 1
C4553962 BXGD023553 Hyperkeratosis, CTCAE
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4733092 BXGD023907 estrogen receptor-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0005066 2R,3R-Butanediol 90.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein