Showing entry for Leucine-rich repeat serine/threonine-protein kinase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT015650
Protein NameLeucine-rich repeat serine/threonine-protein kinase 2
Uniport IdQ5S007
GeneLRRK2
Gene Id120892
DomainCOR; LRR_8; Pkinase; Roc
Pfam PF16095   PF13855   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.4 Neurodegenerative diseases hsa05012 Parkinson disease
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0000186 activation of MAPKK activity
Biological Process GO:0006914 autophagy
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:0060070 canonical Wnt signaling pathway
Biological Process GO:0034613 cellular protein localization
Biological Process GO:1903351 cellular response to dopamine
Biological Process GO:0071287 cellular response to manganese ion
Biological Process GO:0071407 cellular response to organic cyclic compound
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0009267 cellular response to starvation
Biological Process GO:0008340 determination of adult lifespan
Biological Process GO:0006897 endocytosis
Biological Process GO:0007029 endoplasmic reticulum organization
Biological Process GO:0060079 excitatory postsynaptic potential
Biological Process GO:0035640 exploration behavior
Biological Process GO:0007030 Golgi organization
Biological Process GO:0046039 GTP metabolic process
Biological Process GO:0048312 intracellular distribution of mitochondria
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0035641 locomotory exploration behavior
Biological Process GO:0007040 lysosome organization
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0051646 mitochondrion localization
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:1902902 negative regulation of autophagosome assembly
Biological Process GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Biological Process GO:0090394 negative regulation of excitatory postsynaptic potential
Biological Process GO:0034260 negative regulation of GTPase activity
Biological Process GO:1903206 negative regulation of hydrogen peroxide-induced cell death
Biological Process GO:1902823 negative regulation of late endosome to lysosome transport
Biological Process GO:0016242 negative regulation of macroautophagy
Biological Process GO:1901215 negative regulation of neuron death
Biological Process GO:0010977 negative regulation of neuron projection development
Biological Process GO:0032091 negative regulation of protein binding
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0010955 negative regulation of protein processing
Biological Process GO:1903217 negative regulation of protein processing involved in protein targeting to mitochondrion
Biological Process GO:1903215 negative regulation of protein targeting to mitochondrion
Biological Process GO:1903125 negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
Biological Process GO:0007528 neuromuscular junction development
Biological Process GO:0070997 neuron death
Biological Process GO:0140058 neuron projection arborization
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0021772 olfactory bulb development
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:0016310 phosphorylation
Biological Process GO:0010508 positive regulation of autophagy
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:0060161 positive regulation of dopamine receptor signaling pathway
Biological Process GO:1901727 positive regulation of histone deacetylase activity
Biological Process GO:0043406 positive regulation of MAP kinase activity
Biological Process GO:1903980 positive regulation of microglial cell activation
Biological Process GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
Biological Process GO:0043068 positive regulation of programmed cell death
Biological Process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:1902499 positive regulation of protein autoubiquitination
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0031398 positive regulation of protein ubiquitination
Biological Process GO:1900244 positive regulation of synaptic vesicle endocytosis
Biological Process GO:1904469 positive regulation of tumor necrosis factor secretion
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0070973 protein localization to endoplasmic reticulum exit site
Biological Process GO:0070585 protein localization to mitochondrion
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0072593 reactive oxygen species metabolic process
Biological Process GO:0010506 regulation of autophagy
Biological Process GO:2000172 regulation of branching morphogenesis of a nerve
Biological Process GO:1905289 regulation of CAMKK-AMPK signaling cascade
Biological Process GO:0060828 regulation of canonical Wnt signaling pathway
Biological Process GO:0061001 regulation of dendritic spine morphogenesis
Biological Process GO:0060159 regulation of dopamine receptor signaling pathway
Biological Process GO:0060628 regulation of ER to Golgi vesicle-mediated transport
Biological Process GO:0035564 regulation of kidney size
Biological Process GO:0040012 regulation of locomotion
Biological Process GO:0035751 regulation of lysosomal lumen pH
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0051900 regulation of mitochondrial depolarization
Biological Process GO:0090140 regulation of mitochondrial fission
Biological Process GO:1902692 regulation of neuroblast proliferation
Biological Process GO:1901214 regulation of neuron death
Biological Process GO:0014041 regulation of neuron maturation
Biological Process GO:0010738 regulation of protein kinase A signaling
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:1905279 regulation of retrograde transport, endosome to Golgi
Biological Process GO:0051966 regulation of synaptic transmission, glutamatergic
Biological Process GO:2000300 regulation of synaptic vesicle exocytosis
Biological Process GO:1902803 regulation of synaptic vesicle transport
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0007165 signal transduction
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0021756 striatum development
Biological Process GO:0022028 tangential migration from the subventricular zone to the olfactory bulb
Biological Process GO:1904887 Wnt signalosome assembly
molecular function GO:0003779 actin binding
molecular function GO:0005524 ATP binding
molecular function GO:1904713 beta-catenin destruction complex binding
molecular function GO:0030276 clathrin binding
molecular function GO:0039706 co-receptor binding
molecular function GO:0005096 GTPase activator activity
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0034211 GTP-dependent protein kinase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0044325 ion channel binding
molecular function GO:0016301 kinase activity
molecular function GO:0000287 magnesium ion binding
molecular function GO:0004708 MAP kinase kinase activity
molecular function GO:0008017 microtubule binding
molecular function GO:0036479 peroxidase inhibitor activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0051018 protein kinase A binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0004722 protein serine/threonine phosphatase activity
molecular function GO:0017048 Rho GTPase binding
molecular function GO:0030159 signaling receptor complex adaptor activity
molecular function GO:0000149 SNARE binding
molecular function GO:0017075 syntaxin-1 binding
molecular function GO:0015631 tubulin binding
cellular component GO:0044753 amphisome
cellular component GO:0044754 autolysosome
cellular component GO:0030424 axon
cellular component GO:0099400 caveola neck
cellular component GO:0005737 cytoplasm
cellular component GO:0032473 cytoplasmic side of mitochondrial outer membrane
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005829 cytosol
cellular component GO:0030425 dendrite
cellular component GO:0032839 dendrite cytoplasm
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0070971 endoplasmic reticulum exit site
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0005768 endosome
cellular component GO:0070062 extracellular exosome
cellular component GO:0005615 extracellular space
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005798 Golgi-associated vesicle
cellular component GO:0000139 Golgi membrane
cellular component GO:0030426 growth cone
cellular component GO:0016234 inclusion body
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005764 lysosome
cellular component GO:0045121 membrane raft
cellular component GO:0005902 microvillus
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0031966 mitochondrial membrane
cellular component GO:0005741 mitochondrial outer membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0097487 multivesicular body, internal vesicle
cellular component GO:0043025 neuronal cell body
cellular component GO:0043005 neuron projection
cellular component GO:0005654 nucleoplasm
cellular component GO:0043204 perikaryon
cellular component GO:0005886 plasma membrane
cellular component GO:0098794 postsynapse
cellular component GO:1990904 ribonucleoprotein complex
cellular component GO:0030672 synaptic vesicle membrane
cellular component GO:0043195 terminal bouton
cellular component GO:0005802 trans-Golgi network
cellular component GO:1990909 Wnt signalosome
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-8848021 Signaling by PTK6
R-HSA-8857538 PTK6 promotes HIF1A stabilization
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004930 BXGD000294 Behavior Disorders Mental Disorders
C0004936 BXGD000295 Mental disorders Mental Disorders
C0004941 BXGD000296 Behavioral Symptoms Behavior and Behavior Mechanisms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0008313 BXGD000528 Cholangitis, Sclerosing Digestive System Diseases
C0009171 BXGD000587 Cocaine Abuse Chemically-Induced Disorders; Mental Disorders
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009398 BXGD000604 Color vision defect Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0009447 BXGD000613 Common Variable Immunodeficiency Immune System Diseases
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011303 BXGD000712 Demyelinating Diseases Nervous System Diseases
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011882 BXGD000761 Diabetic Neuropathies Nervous System Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0012236 BXGD000772 DiGeorge Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0012569 BXGD000777 Diplopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0012833 BXGD000795 Dizziness Pathological Conditions, Signs and Symptoms
C0013363 BXGD000818 Dysautonomia Nervous System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013720 BXGD000861 Ehlers-Danlos Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0014038 BXGD000878 Encephalitis Nervous System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0017639 BXGD001133 Gliosis Pathological Conditions, Signs and Symptoms
C0018524 BXGD001200 Hallucinations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0020651 BXGD001460 Hypotension, Orthostatic Nervous System Diseases; Cardiovascular Diseases
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021831 BXGD001516 Intestinal Diseases Digestive System Diseases
C0023343 BXGD001635 Leprosy Infections
C0023418 BXGD001642 leukemia Neoplasms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026918 BXGD001948 Mycobacterium Infections Infections
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027497 BXGD001993 Nausea Pathological Conditions, Signs and Symptoms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027697 BXGD002022 Nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027849 BXGD002049 Neuroleptic Malignant Syndrome Nervous System Diseases; Chemically-Induced Disorders
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0030569 BXGD002242 Secondary Parkinson Disease Nervous System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0035258 BXGD002523 Restless Legs Syndrome Nervous System Diseases; Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0038868 BXGD002781 Progressive supranuclear palsy Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042798 BXGD003003 Low Vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0085084 BXGD003121 Motor Neuron Disease Nervous System Diseases
C0085623 BXGD003210 Akinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085631 BXGD003214 Agitation Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085632 BXGD003215 Apathy Behavior and Behavior Mechanisms
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0086769 BXGD003310 Panic Attacks Mental Disorders
C0087012 BXGD003318 Ataxia, Spinocerebellar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0150080 BXGD003402 Social Communication Disorder Mental Disorders
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152020 BXGD003519 Gastroparesis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0220870 BXGD004347 Lightheadedness Pathological Conditions, Signs and Symptoms
C0221170 BXGD004400 Muscular stiffness Nervous System Diseases
C0231688 BXGD004510 Gait, Shuffling Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233401 BXGD004575 Psychiatric symptom
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233763 BXGD004611 Hallucinations, Visual Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234379 BXGD004662 Resting Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235162 BXGD004727 Difficulty sleeping Mental Disorders
C0236642 BXGD004815 Pick Disease of the Brain Nervous System Diseases; Mental Disorders
C0236734 BXGD004823 Caffeine related disorders
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0242423 BXGD005164 Ramsay Hunt Paralysis Syndrome Nervous System Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0262630 BXGD005262 Reduced concentration span Behavior and Behavior Mechanisms
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0270699 BXGD006085 Neonatal maladjustment syndrome
C0270715 BXGD006089 Degenerative Diseases, Central Nervous System Nervous System Diseases
C0270736 BXGD006096 Essential Tremor Nervous System Diseases
C0272401 BXGD006365 Virchow's node (disorder)
C0278097 BXGD006496 Abnormal male sexual function
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0282513 BXGD006808 Primary Progressive Aphasia (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0333641 BXGD006961 Atrophic Pathological Conditions, Signs and Symptoms
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0338455 BXGD007177 Dementia of frontal lobe type Nervous System Diseases; Mental Disorders
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0338908 BXGD007218 Mixed anxiety and depressive disorder Mental Disorders
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0393570 BXGD008093 Corticobasal degeneration Nervous System Diseases
C0393571 BXGD008094 Multiple System Atrophy Nervous System Diseases
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0401149 BXGD008273 Chronic constipation Pathological Conditions, Signs and Symptoms
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424296 BXGD008525 Social disinhibition Mental Disorders
C0426980 BXGD008599 Motor symptoms
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0543859 BXGD009298 Amyotrophic Lateral Sclerosis, Guam Form Nutritional and Metabolic Diseases; Nervous System Diseases
C0548883 BXGD009356 Low frustration tolerance Behavior and Behavior Mechanisms
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0679407 BXGD009772 Gastrointestinal dysfunction Digestive System Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0751072 BXGD010312 Frontotemporal Lobar Degeneration Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0751772 BXGD010583 REM Sleep Behavior Disorder Nervous System Diseases; Mental Disorders
C0751783 BXGD010592 Lafora Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752097 BXGD010659 Autosomal Dominant Juvenile Parkinson Disease Nervous System Diseases
C0752098 BXGD010660 Autosomal Dominant Parkinsonism Nervous System Diseases
C0752100 BXGD010661 Autosomal Recessive Parkinsonism Nervous System Diseases
C0752101 BXGD010662 Parkinsonism, Experimental Nervous System Diseases
C0752104 BXGD010663 Familial Juvenile Parkinsonism Nervous System Diseases
C0752105 BXGD010664 Parkinsonism, Juvenile Nervous System Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0813217 BXGD010854 Expressionless face Nervous System Diseases
C0850703 BXGD010905 Frequent falls Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0856169 BXGD011096 Endothelial dysfunction
C0860603 BXGD011236 Anxiety symptoms
C0871388 BXGD011314 social stress Behavior and Behavior Mechanisms
C0917801 BXGD011412 Sleeplessness Nervous System Diseases; Mental Disorders
C0920350 BXGD011466 Autoimmune thyroiditis Immune System Diseases; Endocrine System Diseases
C0947785 BXGD011495 [D]Sleep disturbances (& [hypersomnia] or [insomnia])
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1112442 BXGD011668 Female sexual dysfunction
C1112443 BXGD011669 Male sexual dysfunction
C1145628 BXGD011763 Autonomic nervous system disorders Nervous System Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1266042 BXGD011938 Chromophobe Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1266043 BXGD011939 Sarcomatoid Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1266044 BXGD011940 Collecting Duct Carcinoma of the Kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1285162 BXGD012167 Degenerative disorder Pathological Conditions, Signs and Symptoms
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306837 BXGD012377 Papillary Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1335167 BXGD012768 Ovarian Mucinous Adenocarcinoma Neoplasms
C1335177 BXGD012771 Ovarian Serous Adenocarcinoma Neoplasms
C1335723 BXGD012806 Refractory Follicular Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1445957 BXGD013081 Serum total cholesterol measurement
C1611743 BXGD013456 Familial (FPAH)
C1836150 BXGD014082 Gait imbalance
C1836904 BXGD014176 Spastic/hyperactive bladder
C1843013 BXGD014549 Alzheimer disease, familial, type 3 Nervous System Diseases; Mental Disorders
C1843921 BXGD014620 Postural instability Nervous System Diseases
C1846862 BXGD014844 PARKINSON DISEASE 8 (disorder)
C1846865 BXGD014845 Substantia nigra gliosis Pathological Conditions, Signs and Symptoms
C1846868 BXGD014846 Parkinsonism with favorable response to dopaminergic medication Nervous System Diseases
C1847640 BXGD014879 KUFOR-RAKEB SYNDROME Nervous System Diseases
C1854494 BXGD015409 Slow progression
C1868193 BXGD016493 PNEUMOTHORAX, PRIMARY SPONTANEOUS
C1868528 BXGD016503 Orthostatic hypotension due to autonomic dysfunction Nervous System Diseases; Cardiovascular Diseases
C1868596 BXGD016513 Atypical Parkinson Disease Nervous System Diseases
C1868675 BXGD016520 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE Nervous System Diseases
C1963060 BXGD016679 Agitation, CTCAE 3.0
C2364082 BXGD017123 Sense of smell impaired Nervous System Diseases
C2609259 BXGD017173 Symphysis Pubis Dysfunction Pathological Conditions, Signs and Symptoms
C2751012 BXGD017688 PARKINSON DISEASE 16 (disorder) Nervous System Diseases
C2830004 BXGD017804 Somnolence Pathological Conditions, Signs and Symptoms
C3150797 BXGD018337 AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6
C3160718 BXGD018468 PARKINSON DISEASE, LATE-ONSET
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3489791 BXGD018949 Parkinson Disease, Familial, Type 1 Nervous System Diseases
C3494361 BXGD018964 Prodromal Stage Pathological Conditions, Signs and Symptoms
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3811918 BXGD019664 GRN-related frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C3825201 BXGD019684 Mitochondrial pathology
C4014795 BXGD020166 AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
C4020732 BXGD020474 Mitochondrial abnormalities
C4049471 BXGD021934 End stage Parkinson's disease
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4274355 BXGD022352 Autosomal dominant late onset Parkinson disease Nervous System Diseases
C4275179 BXGD022368 Young onset Parkinson disease Nervous System Diseases
C4284013 BXGD022428 Primary cholangiocarcinoma of intrahepatic biliary tract Neoplasms
C4285807 BXGD022455 Behavioral and psychological symptoms of dementia
C4302185 BXGD022525 Atypical Parkinsonism Nervous System Diseases
C4310768 BXGD022658 AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2
C4511452 BXGD023002 Sporadic Parkinson disease Nervous System Diseases
C4531121 BXGD023189 Monotonic speech
C4531177 BXGD023202 Sleep onset Insomnia Nervous System Diseases; Mental Disorders
C4551583 BXGD023361 Cerebral cortical atrophy
C4551761 BXGD023405 Excessive daytime sleepiness
C4552855 BXGD023528 Agitation, CTCAE 5.0
C4553743 BXGD023548 Spasticity, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0013109 4-[2-(3,5-Dihydroxyphenyl)Ethenyl]Benzene-1,2-Diol 244.07
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein