Showing entry for Quinidine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0035201
Compound NameQuinidine
Structure
FormulaC20H24N2O2
InchiKeyLOUPRKONTZGTKE-LHHVKLHASA-N
SMILESC=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@H](c1ccnc2c1cc(OC)cc2)O
InchiInChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1
IUPAC(S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
Molecular Weight324.18
Pubchem Id441074
Chembl IdCHEMBL1294
Targets of Information Source
DrugBank DB00908
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Q14524 BXGT013478 Sodium channel protein type 5 subunit alpha reviewed Ion channel SCN5A approved; investigational inhibitor
O00180 BXGT003888 Potassium channel subfamily K member 1 reviewed Ion channel KCNK1 approved; investigational inhibitor
Q9Y257 BXGT022218 Potassium channel subfamily K member 6 reviewed Ion channel KCNK6 approved; investigational inhibitor
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 approved; investigational inhibitor
P35348 BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A approved; investigational antagonist
P35368 BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B approved; investigational antagonist
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D approved; investigational antagonist
PDB QDN
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P10635 BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - - - - -
Binding DB 50121975
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed UGT1A1 - >3.00e+5 - -
reviewed BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed UGT1A4 - 166000 - -
reviewed BXGT008468 UDP-glucuronosyltransferase 1-6 reviewed UGT1A6 - >3.00e+5 - -
reviewed BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed UGT2B7 - >3.00e+5 - -
reviewed BXGT009924 UDP-glucuronosyltransferase 2B10 reviewed UGT2B10 - >3.00e+5 - -
reviewed BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 - 1440 - -
reviewed BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 - 324 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - <6.0 - -
reviewed BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C - 19820 - -
reviewed BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Cacna1c - 10000 - -
reviewed BXGT004533 Voltage-dependent L-type calcium channel subunit alpha-1C (Fragment) reviewed CACNA1C - 15600 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 0.018 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 30 - -
reviewed BXGT010214 1,3-beta-glucan synthase component GSC2 reviewed GSC2 - 2670 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 17 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 9 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 60 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 41 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 151 - -
reviewed BXGT009838 Sodium channel protein type 1 subunit alpha reviewed Ion channel SCN1A - 3200 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 2600 - - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 5000 - - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 340000 - -
reviewed BXGT007860 Cytochrome P450 2D3 reviewed Cyp2d3 - 26900 - -
reviewed BXGT007593 Cytochrome P450 2D1 reviewed Cyp2d1 - 19900 - -
reviewed BXGT007594 Cytochrome P450 2D26 reviewed Cyp2d26 - 2800 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 3.3 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 2200 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 5600 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 10 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 30 - - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 410 - -
reviewed BXGT006343 Histidine-rich protein PFHRP-II reviewed - - 325000 - -
reviewed BXGT016081 Potassium voltage-gated channel subfamily D member 2 reviewed Kcnd2 - 2200 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 11 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 78 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 82 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 14 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 14000 - -
reviewed BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 - 113800 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 20 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 9.8 - - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 7370 - -
reviewed BXGT019660 Multidrug and toxin extrusion protein 1 reviewed Transporter SLC47A1 - 11200 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 2 - -
CHEMBL CHEMBL1294
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Activity - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 31 nM
P02768 BXGT005955 Serum albumin reviewed Transporter ALB Log K' '=' 0 -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Km '=' 18200 nM
Q6PSM0 BXGT016483 Multidrug resistance protein 1a unreviewed - Mdr1a Km '=' 5000 nM
P21447 BXGT008651 ATP-dependent translocase ABCB1 reviewed - Abcb1a Activity - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ki '=' 1500 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition '=' 96 %
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ki '=' 2600 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki '=' 40 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 1230 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Potency - 7943 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition '=' 88 %
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Activity - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 '=' 300 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 12995 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ratio_Papp '=' 27 -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 78 nM
Q9NY46 BXGT021248 Sodium channel protein type 3 subunit alpha reviewed Ion channel SCN3A IC50 '=' 3200 nM
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha reviewed Ion channel SCN2A IC50 '=' 3200 nM
P35498 BXGT009838 Sodium channel protein type 1 subunit alpha reviewed Ion channel SCN1A IC50 '=' 3200 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 120 nM
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 Activity '=' 5 uM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Inhibition - - -
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 25118 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 10 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 44668 nM
Q14524 BXGT013478 Sodium channel protein type 5 subunit alpha reviewed Ion channel SCN5A IC50 '=' 6900 nM
P15387 BXGT008117 Potassium voltage-gated channel subfamily B member 1 reviewed - Kcnb1 IC50 - - -
P21447 BXGT008651 ATP-dependent translocase ABCB1 reviewed - Abcb1a IC50 '=' 13000 nM
Q9R0W2 BXGT021408 Solute carrier family 22 member 2 reviewed - Slc22a2 IC50 '=' 14600 nM
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 IC50 '=' 113800 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Activity '=' 0 %
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 5600 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 82 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity '=' 36 %
P05227 BXGT006343 Histidine-rich protein PFHRP-II reviewed - IC50 '=' 325000 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 18800 nM
P12938 BXGT007860 Cytochrome P450 2D3 reviewed - Cyp2d3 IC50 '=' 26900 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 3 nM
Q9Z0E8 BXGT022397 Solute carrier family 22 member 5 reviewed - Slc22a5 Activity '=' 6 %
Q9H015 BXGT020432 Solute carrier family 22 member 4 reviewed Transporter SLC22A4 Activity - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ki '=' 5000 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 11 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 19 nM
Q9NY46 BXGT021248 Sodium channel protein type 3 subunit alpha reviewed Ion channel SCN3A Inhibition '=' 74 %
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha reviewed Ion channel SCN2A Inhibition '=' 74 %
P35498 BXGT009838 Sodium channel protein type 1 subunit alpha reviewed Ion channel SCN1A Inhibition '=' 74 %
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 '=' 323 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Inhibition '=' 100 %
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ratio '=' 7 -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 14 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 14000 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Binding site fraction '=' 0 -
O35505 BXGT004533 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - CACNA1C IC50 '=' 15600 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 410 nM
Q63089 BXGT016060 Solute carrier family 22 member 1 reviewed - Slc22a1 IC50 '=' 12700 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki '=' 30 nM
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 20 nM
P46721 BXGT010536 Solute carrier organic anion transporter family member 1A2 reviewed Transporter SLCO1A2 Activity '=' 91 %
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 9 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 Inhibition '=' 62 %
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 37 %
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Papp '=' 36 nm/s
P00811 BXGT005666 Beta-lactamase reviewed - ampC Potency '=' 8912 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Papp '=' 34 10'-6 cm/s
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 reviewed Transporter ABCC3 IC50 '=' 133000 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 '=' 1440 nM
P10633 BXGT007593 Cytochrome P450 2D1 reviewed - Cyp2d1 IC50 '=' 19900 nM
P10634 BXGT007594 Cytochrome P450 2D26 reviewed - Cyp2d26 IC50 '=' 2800 nM
Q64680 BXGT016129 Cytochrome P450 2D4 reviewed - Cyp2d4 IC50 '=' 47200 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Inhibition '=' 23 %
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c IC50 '=' 5600 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki '=' 9 nM
Q63089 BXGT016060 Solute carrier family 22 member 1 reviewed - Slc22a1 Ki '=' 6000 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ki '=' 8590 nM
O76082 BXGT005175 Solute carrier family 22 member 5 reviewed Transporter SLC22A5 Inhibition '=' 89 %
O08966 BXGT004046 Solute carrier family 22 member 1 reviewed - Slc22a1 Activity '=' 0 %
Q9H015 BXGT020432 Solute carrier family 22 member 4 reviewed Transporter SLC22A4 Activity '=' 15 %
O15244 BXGT004140 Solute carrier family 22 member 2 reviewed Transporter SLC22A2 Activity - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Km '=' 5420 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 340000 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki '=' 80 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition '=' 90 %
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 135 nM
Q96FL8 BXGT019660 Multidrug and toxin extrusion protein 1 reviewed Transporter SLC47A1 Inhibition '=' 28 %
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Activity - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Activity - - -
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 Ki '=' 17500 nM
P22460 BXGT008774 Potassium voltage-gated channel subfamily A member 5 reviewed Ion channel KCNA5 IC50 '=' 7300 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 '>' 50000 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki '=' 43 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Papp '=' 4 10'-6 cm/s
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Inhibition '=' 36 %
Q14524 BXGT013478 Sodium channel protein type 5 subunit alpha reviewed Ion channel SCN5A IC50 '=' 16600 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 25100 nM
P06795 BXGT006507 ATP-dependent translocase ABCB1 reviewed - Abcb1b IC50 '=' 10000 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Activity '=' 81 %
Q8TCC7 BXGT018794 Solute carrier family 22 member 8 reviewed Transporter SLC22A8 Activity - - -
O76082 BXGT005175 Solute carrier family 22 member 5 reviewed Transporter SLC22A5 Activity '=' 9 %
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Inhibition - - -
Q63089 BXGT016060 Solute carrier family 22 member 1 reviewed - Slc22a1 Km '=' 2200 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 12589 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Inhibition '=' 21 %
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 2200 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki '=' 60 nM
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 Activity '=' 20 %
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 35481 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 23109 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 14960 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Inhibition '=' 9 %
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki '=' 32000 nM
Q63881 BXGT016081 Potassium voltage-gated channel subfamily D member 2 reviewed - Kcnd2 IC50 '=' 2200 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Papp '=' 990 nm/s
Q86VL8 BXGT017618 Multidrug and toxin extrusion protein 2 reviewed Transporter SLC47A2 Activity - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 15848 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c IC50 '=' 10000 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity '=' 20 nM/mg*min
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 17782 nM
Q63089 BXGT016060 Solute carrier family 22 member 1 reviewed - Slc22a1 Activity - - -
P15389 BXGT008118 Sodium channel protein type 5 subunit alpha reviewed - Scn5a Inhibition '=' 68 %
Q96FL8 BXGT019660 Multidrug and toxin extrusion protein 1 reviewed Transporter SLC47A1 IC50 '=' 11200 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '<' 6 nM
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 Activity - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P46720 BXGT010535 Solute carrier organic anion transporter family member 1A1 reviewed - Slco1a1 Ki '=' 9270 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 17 nM
O35913 BXGT004540 Solute carrier organic anion transporter family member 1A4 reviewed - Slco1a4 Ki '=' 120000 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 - - -
O76082 BXGT005175 Solute carrier family 22 member 5 reviewed Transporter SLC22A5 Activity - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ki '=' 430 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Inhibition '=' 36 %
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 25000 nM
Q96FL8 BXGT019660 Multidrug and toxin extrusion protein 1 reviewed Transporter SLC47A1 Activity - - -
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 IC50 '=' 45800 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ratio_ATPase activity '=' 2 -
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 7370 nM
O60840 BXGT004901 Voltage-dependent L-type calcium channel subunit alpha-1F reviewed Ion channel CACNA1F IC50 '=' 6400 nM
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed Ion channel CACNA1D IC50 '=' 6400 nM
Q13698 BXGT013392 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed Ion channel CACNA1S IC50 '=' 6400 nM
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C IC50 '=' 6400 nM
P46721 BXGT010536 Solute carrier organic anion transporter family member 1A2 reviewed Transporter SLCO1A2 Activity - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 % maximum response '=' 30 %
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 151 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition '=' 21 %
P0A0J7 BXGT006970 Quinolone resistance protein NorA reviewed - norA Inhibition '=' 31 %
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition '=' 95 %
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ratio IC50 '=' 2 -
P04156 BXGT006156 Major prion protein reviewed - PRNP RUmax - - -
Q63089 BXGT016060 Solute carrier family 22 member 1 reviewed - Slc22a1 Ki '=' 14600 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Inhibition '=' 85 %
O94956 BXGT005343 Solute carrier organic anion transporter family member 2B1 reviewed Transporter SLCO2B1 Inhibition '=' -10 %
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 33800 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 30 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 41 nM
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C IC50 '=' 19820 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 1000 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 33900 nM
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 IC50 '=' 23400 nM
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 Activity '=' 64 %
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 43 %
Q9R0W2 BXGT021408 Solute carrier family 22 member 2 reviewed - Slc22a2 Ki '=' 19100 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 18 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition '=' 93 %
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 2 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 5000 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 25 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Inhibition - - -
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 Activity - - -
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 133000 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 35 nM
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 IC50 '=' 133000 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Activity '=' 21 %
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '>' 135000 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 '=' 2670 nM
Q9H015 BXGT020432 Solute carrier family 22 member 4 reviewed Transporter SLC22A4 Inhibition '=' 83 %
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 60 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 118 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition '=' 93 %
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition '=' 91 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF03950 Cinchona calisaya Cinchona calisaya Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease