Showing entry for Fibrinogen beta chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005916
Protein NameFibrinogen beta chain
Uniport IdP02675
GeneFGB
Gene Id2244
DomainFibrinogen_C; Fib_alpha
Pfam PF08702   PF00147  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0007596 blood coagulation
Biological Process GO:0072378 blood coagulation, fibrin clot formation
Biological Process GO:0007155 cell adhesion
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0034622 cellular protein-containing complex assembly
Biological Process GO:0071347 cellular response to interleukin-1
Biological Process GO:0044320 cellular response to leptin stimulus
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0042730 fibrinolysis
Biological Process GO:0043152 induction of bacterial agglutination
Biological Process GO:0045087 innate immune response
Biological Process GO:2000352 negative regulation of endothelial cell apoptotic process
Biological Process GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Process GO:0031639 plasminogen activation
Biological Process GO:0070527 platelet aggregation
Biological Process GO:0002576 platelet degranulation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0045921 positive regulation of exocytosis
Biological Process GO:0034116 positive regulation of heterotypic cell-cell adhesion
Biological Process GO:0090277 positive regulation of peptide hormone secretion
Biological Process GO:0050714 positive regulation of protein secretion
Biological Process GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Biological Process GO:0045907 positive regulation of vasoconstriction
Biological Process GO:0051258 protein polymerization
Biological Process GO:0051592 response to calcium ion
Biological Process GO:0002224 toll-like receptor signaling pathway
molecular function GO:0051087 chaperone binding
molecular function GO:0005201 extracellular matrix structural constituent
molecular function GO:0005102 signaling receptor binding
molecular function GO:0005198 structural molecule activity
cellular component GO:0072562 blood microparticle
cellular component GO:0005938 cell cortex
cellular component GO:0009986 cell surface
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:1903561 extracellular vesicle
cellular component GO:0005577 fibrinogen complex
cellular component GO:0005886 plasma membrane
cellular component GO:0031091 platelet alpha granule
cellular component GO:0031093 platelet alpha granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-114608 Platelet degranulation
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade)
R-HSA-1474244 Extracellular matrix organization
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-216083 Integrin cell surface interactions
R-HSA-354192 Integrin signaling
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-9607240 FLT3 Signaling
R-HSA-9649948 Signaling downstream of RAS mutants
R-HSA-9656223 Signaling by RAF1 mutants
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000786 BXGD000010 Spontaneous abortion Female Urogenital Diseases and Pregnancy Complications
C0001733 BXGD000073 Afibrinogenemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0001787 BXGD000076 Osteoporosis, Age-Related Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007273 BXGD000455 Carotid Artery Diseases Nervous System Diseases; Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014591 BXGD000938 Epistaxis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0015503 BXGD000998 Factor VII Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0017181 BXGD001103 Gastrointestinal Hemorrhage Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0017565 BXGD001118 Gingival Hemorrhage Pathological Conditions, Signs and Symptoms; Stomatognathic Diseases
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023234 BXGD001622 Legg-Calve-Perthes Disease Musculoskeletal Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029459 BXGD002159 Osteoporosis, Senile Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0034065 BXGD002454 Pulmonary Embolism Respiratory Tract Diseases; Cardiovascular Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040053 BXGD002839 Thrombosis Cardiovascular Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042487 BXGD002986 Venous Thrombosis Cardiovascular Diseases
C0085096 BXGD003123 Peripheral Vascular Diseases Cardiovascular Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152031 BXGD003524 Joint swelling Pathological Conditions, Signs and Symptoms
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0232943 BXGD004570 Intermenstrual heavy bleeding Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0265493 BXGD005538 Cat eye syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0272350 BXGD006354 Dysfibrinogenemia, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0337428 BXGD007155 Fibrinogen assay
C0340293 BXGD007318 Anterior myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0398623 BXGD008202 Thrombophilia Hemic and Lymphatic Diseases
C0472803 BXGD008925 Hypodysfibrinogenemia
C0553681 BXGD009406 Hypofibrinogenemia
C0577631 BXGD009535 Carotid Atherosclerosis Nervous System Diseases; Cardiovascular Diseases
C0584960 BXGD009579 Factor V Leiden mutation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0747479 BXGD010170 Periodontal infection
C0751406 BXGD010428 Post-Traumatic Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1260903 BXGD011842 Dysfibrinogenemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1261287 BXGD011852 Stenosis Pathological Conditions, Signs and Symptoms
C1262005 BXGD011860 Ischaemic cerebral infarction
C1325327 BXGD012455 fibrinogen activity
C1445957 BXGD013081 Serum total cholesterol measurement
C1458140 BXGD013134 Bleeding tendency Hemic and Lymphatic Diseases
C1531624 BXGD013300 Cardioembolic stroke
C1561955 BXGD013367 Fibrinogen, CTCAE
C1611743 BXGD013456 Familial (FPAH)
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2584409 BXGD017126 Prothrombin G20210A mutation Hemic and Lymphatic Diseases
C2584774 BXGD017130 Congenital hypofibrinogenemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C2609253 BXGD017172 Macrovascular disease
C2826323 BXGD017790 Refractory Cytopenia of Childhood
C2937358 BXGD018159 Cerebral Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C3160844 BXGD018482 PAI-1 polymorphism
C3463916 BXGD018901 Complement Factor I (C3 inactivator) deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C3845502 BXGD019809 Myocardial infarction, stroke
C4316812 BXGD022704 Fibrinogen Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C4552766 BXGD023523 Miscarriage Female Urogenital Diseases and Pregnancy Complications
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000194 Sanguinarine 332.33
BXGC0002586 Calcium 40.08
BXGC0014919 Citrulline 175.1
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein