Showing entry for Sanguinarine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000194
Compound NameSanguinarine
Structure
FormulaC20H14NO4
InchiKeyINVGWHRKADIJHF-UHFFFAOYSA-N
SMILESC[N+]1=C2C3=CC4=C(OCO4)C=C3C=CC2=C2C=CC3=C(OCO3)C2=C1
InchiInChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1
IUPAC24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,1?.0?,?.01?,22.01?,21]tetracosa-1(24),2,4(8),9,11,13,15,17(21),22-nonaen-24-ium
Molecular Weight332.33
Pubchem Id5154
Chembl IdCHEMBL417799
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB SAU
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Q9AMP1 BXGT020080 Chitinase A unreviewed chiA - - - - -
Q5C9L7 BXGT015298 (RS)-norcoclaurine 6-O-methyltransferase reviewed - - - - -
P60842 BXGT011330 Eukaryotic initiation factor 4A-I reviewed EIF4A1 - - - 12500 -
Binding DB 25525
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 - 19000 - -
reviewed BXGT008594 Aromatic-L-amino-acid decarboxylase reviewed DDC - 200000 - -
reviewed BXGT011342 Cell division control protein 42 homolog reviewed Enzyme modulator CDC42 - 32000 - -
reviewed BXGT011481 Ras-related C3 botulinum toxin substrate 1 reviewed Enzyme modulator RAC1 - 58000 - -
CHEMBL CHEMBL417799
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 10000 nM
Q92934 BXGT019396 Bcl2-associated agonist of cell death reviewed - BAD IC50 '=' 19000 nM
P25409 BXGT009043 Alanine aminotransferase 1 reviewed - Gpt Protection '=' 81 %
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 8087 nM
Q9HC16 BXGT020525 DNA dC->dU-editing enzyme APOBEC-3G reviewed Enzyme APOBEC3G Potency - 3548 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 2908 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 10000 nM
P25409 BXGT009043 Alanine aminotransferase 1 reviewed - Gpt Inhibition '=' 20 %
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 17782 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 17782 nM
P02675 BXGT005916 Fibrinogen beta chain reviewed Signaling FGB IC50 '>' 83135 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 580 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 3981 nM
Q04206 BXGT012754 Transcription factor p65 reviewed Transcription factor RELA IC50 '=' 2000 nM
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 IC50 '=' 2000 nM
Q00653 BXGT012541 Nuclear factor NF-kappa-B p100 subunit reviewed Transcription factor NFKB2 IC50 '=' 2000 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 22387 nM
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 Potency '=' 10000 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 398 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Potency '=' 10000 nM
Q27686 BXGT013930 Pyruvate kinase reviewed - PYK Potency '=' 10000 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 28183 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 3162 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 '=' 6309 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 15848 nM
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 15836 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 15848 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 25118 nM
P25409 BXGT009043 Alanine aminotransferase 1 reviewed - Gpt Inhibition '=' 15 %
P42226 BXGT010288 Signal transducer and activator of transcription 6 reviewed Nucleic acid binding STAT6 Potency '=' 10000 nM
O14924 BXGT004111 Regulator of G-protein signaling 12 reviewed - RGS12 Potency '=' 25118 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 10000 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 10000 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency '=' 12589 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency '=' 15848 nM
P14618 BXGT008027 Pyruvate kinase PKM reviewed Kinase PKM Potency '=' 10000 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 10000 nM
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 46109 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 1888 nM
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 7943 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 47 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 3981 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 '=' 3162 nM
Q99816 BXGT019966 Tumor susceptibility gene 101 protein reviewed Enzyme TSG101 Potency - 56234 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 31622 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 28183 nM
P42858 BXGT010341 Huntingtin reviewed - HTT Potency '=' 6309 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 12589 nM
P42226 BXGT010288 Signal transducer and activator of transcription 6 reviewed Nucleic acid binding STAT6 Potency '=' 7943 nM
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 12589 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 18356 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 3162 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 7943 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 3288 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 14125 nM
O14924 BXGT004111 Regulator of G-protein signaling 12 reviewed - RGS12 Potency '=' 12589 nM
P63096 BXGT011496 Guanine nucleotide-binding protein G(i) subunit alpha-1 reviewed Enzyme modulator GNAI1 Potency '=' 12589 nM
O94956 BXGT005343 Solute carrier organic anion transporter family member 2B1 reviewed Transporter SLCO2B1 Inhibition '=' 15 %
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 15848 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 0 %
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 25118 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 580 nM
P25409 BXGT009043 Alanine aminotransferase 1 reviewed - Gpt Protection '=' 5 %
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 12589 nM
P40225 BXGT010168 Thrombopoietin reviewed - THPO Potency '=' 1000 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 17782 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 31622 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 3162 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 2511 nM
P08482 BXGT006775 Muscarinic acetylcholine receptor M1 reviewed - Chrm1 Potency '=' 12589 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 '=' 12589 nM
P02675 BXGT005916 Fibrinogen beta chain reviewed Signaling FGB IC50 '=' 24165 nM
O75604 BXGT005139 Ubiquitin carboxyl-terminal hydrolase 2 reviewed Enzyme USP2 Potency '=' 25118 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 3981 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 2818 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 15848 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 5623 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 11220 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 8912 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 3162 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 6309 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Potency '=' 12589 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 56234 nM
P25409 BXGT009043 Alanine aminotransferase 1 reviewed - Gpt Protection '=' 75 %
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 22387 nM
P37840 BXGT010015 Alpha-synuclein reviewed Transporter SNCA Potency - 35481 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 '=' 15848 nM
P25409 BXGT009043 Alanine aminotransferase 1 reviewed - Gpt Concentration '=' 0 M
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 7079 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 12589 nM
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 2119 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 26 %
P13267 BXGT007895 DNA polymerase III PolC-type reviewed - polC Potency - 8436 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 25118 nM
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 6294 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 7943 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 2 %
P25409 BXGT009043 Alanine aminotransferase 1 reviewed - Gpt Inhibition '=' 74 %
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 '=' 7943 nM
P08482 BXGT006775 Muscarinic acetylcholine receptor M1 reviewed - Chrm1 Potency '=' 141 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 2511 nM
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 17782 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 17782 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 '=' 31622 nM
Q9UGC6 BXGT023734 Regulator of G-protein signaling 17 reviewed Enzyme modulator RGS17 IC50 '=' 72800 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 7208 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 31622 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 '=' 3162 nM
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP reviewed - HSPA5 Potency - 7079 nM
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP reviewed - HSPA5 Potency - 4140 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 6309 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 819 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 1995 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 1 %
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 6309 nM
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 17782 nM
Q9UGC6 BXGT023734 Regulator of G-protein signaling 17 reviewed Enzyme modulator RGS17 Activity - - -
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 3162 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 12589 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 26679 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 17782 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 3162 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 7079 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 6309 nM
Q9UGC6 BXGT023734 Regulator of G-protein signaling 17 reviewed Enzyme modulator RGS17 Inhibition - - -
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 9466 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 7943 nM
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 145809 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 4610 nM
P15289 BXGT008102 Arylsulfatase A reviewed Enzyme ARSA Potency - 21331 nM
P25409 BXGT009043 Alanine aminotransferase 1 reviewed - Gpt ID50 '=' 0 M
Q9UGC6 BXGT023734 Regulator of G-protein signaling 17 reviewed Enzyme modulator RGS17 Kd '=' 1000 nM
P37840 BXGT010015 Alpha-synuclein reviewed Transporter SNCA Potency - 29092 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 35481 nM
Q9UGC6 BXGT023734 Regulator of G-protein signaling 17 reviewed Enzyme modulator RGS17 Activity '=' 16234 Da
Q9UGC6 BXGT023734 Regulator of G-protein signaling 17 reviewed Enzyme modulator RGS17 IC50 '=' 12000 nM
Q9UGC6 BXGT023734 Regulator of G-protein signaling 17 reviewed Enzyme modulator RGS17 IC50 '>' 100000 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00402 Opium poppy Papaver somniferum Herbs and Spices
BXGF00883 Chrozophora prostrata Chrozophora prostrata Medicinal Plant
BXGF01052 Artabotrys maingayi Artabotrys maingayi Medicinal Plant
BXGF01147 Chelidonium majus Chelidonium majus Medicinal Plant
BXGF02254 Thuja plicata Thuja plicata Medicinal Plant
BXGF03260 Garcinia xanthochymus Garcinia xanthochymus Medicinal Plant
BXGF03464 Senna spectabilis Senna spectabilis Medicinal Plant
BXGF03612 Symphytum officinale Symphytum officinale Medicinal Plant
BXGF03764 Psacalium peltatum Psacalium peltatum Medicinal Plant
BXGF03830 Diospyros ebenum Diospyros ebenum Medicinal Plant
BXGF03870 Aloe microstigma Aloe microstigma Others
BXGF03888 Angelica dahurica Angelica dahurica Medicinal Plant
BXGF03971 Corydalis ophiocarpa Corydalis ophiocarpa Medicinal Plant
BXGF04006 Corydalis ternata Corydalis ternata Others
BXGF04055 Teclea sudanica Teclea sudanica Others
BXGF04063 Mezzettia leptopoda Mezzettia leptopoda Others
BXGF04119 Stachys plumosa Stachys plumosa Others
BXGF04178 Piper methysticum Piper methysticum Medicinal Plant
BXGF04190 Lappula echinata Lappula echinata Medicinal Plant
BXGF04237 Ligularia sagitta Ligularia sagitta Medicinal Plant
BXGF04806 Ulex airensis Ulex airensis Others
BXGF05074 Chaetomorpha moniligera Chaetomorpha moniligera Others
BXGF06268 Zanthoxylum nitidum Zanthoxylum nitidum Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease