Showing entry for Coagulation factor XI


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006117
Protein NameCoagulation factor XI
Uniport IdP03951
GeneF11
Gene Id2160
DomainPAN_1; Trypsin
Pfam PF00024   PF00089  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007596 blood coagulation
Biological Process GO:0007597 blood coagulation, intrinsic pathway
Biological Process GO:0031639 plasminogen activation
Biological Process GO:0051919 positive regulation of fibrinolysis
molecular function GO:0008201 heparin binding
molecular function GO:0042802 identical protein binding
molecular function GO:0070009 serine-type aminopeptidase activity
molecular function GO:0004252 serine-type endopeptidase activity
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade)
R-HSA-1643685 Disease
R-HSA-9651496 Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
R-HSA-9668250 Defective factor IX causes hemophilia B
R-HSA-9671793 Diseases of hemostasis
R-HSA-9673221 Defective F9 activation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002623 BXGD000120 Post-traumatic amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003537 BXGD000208 Aphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003855 BXGD000227 Arteriovenous fistula Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005129 BXGD000304 Bernard-Soulier Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008533 BXGD000556 Hemophilia B Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011269 BXGD000710 Dementia, Vascular Nervous System Diseases; Mental Disorders; Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0012546 BXGD000776 Diphtheria Infections
C0014591 BXGD000938 Epistaxis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0015523 BXGD001000 Hereditary Factor XI Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0015526 BXGD001001 Factor XII Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0016169 BXGD001048 pathologic fistula Pathological Conditions, Signs and Symptoms
C0017181 BXGD001103 Gastrointestinal Hemorrhage Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018924 BXGD001249 Hemarthrosis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0019069 BXGD001277 Hemophilia A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0025323 BXGD001864 Menorrhagia Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030605 BXGD002248 Activated Partial Thromboplastin Time measurement
C0031256 BXGD002296 Petechiae Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0032584 BXGD002363 polyps Pathological Conditions, Signs and Symptoms
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040053 BXGD002839 Thrombosis Cardiovascular Diseases
C0040100 BXGD002840 Thymoma Neoplasms; Hemic and Lymphatic Diseases
C0040264 BXGD002857 Tinnitus Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0041207 BXGD002898 Truncus Arteriosus, Persistent Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0042487 BXGD002986 Venous Thrombosis Cardiovascular Diseases
C0042880 BXGD003011 Vitamin K Deficiency Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0042974 BXGD003019 von Willebrand Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0155016 BXGD003765 Color Blindness, Red-Green Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0206586 BXGD004181 Endolymphatic Hydrops Otorhinolaryngologic Diseases
C0220992 BXGD004355 Histidinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0231749 BXGD004520 Knee pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0236642 BXGD004815 Pick Disease of the Brain Nervous System Diseases; Mental Disorders
C0240671 BXGD005048 Partial thromboplastin time increased (finding)
C0241144 BXGD005080 Petechiae of skin Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0271829 BXGD006267 Pendred's syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Endocrine System Diseases; Otorhinolaryngologic Diseases
C0272315 BXGD006341 Coagulation factor deficiency syndrome Hemic and Lymphatic Diseases
C0272324 BXGD006345 Mild hereditary factor VIII deficiency disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0272340 BXGD006351 High molecular weight kininogen deficiency Hemic and Lymphatic Diseases
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0282577 BXGD006816 Congenital Disorders of Glycosylation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0311370 BXGD006882 Lupus anticoagulant disorder Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0332840 BXGD006900 Amputated structure (morphologic abnormality) Wounds and Injuries
C0332853 BXGD006901 Anastomosis
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0340565 BXGD007350 Lower limb ischemia Pathological Conditions, Signs and Symptoms
C0340757 BXGD007363 Inferior vena cava stenosis
C0343401 BXGD007623 MRSA - Methicillin resistant Staphylococcus aureus infection Infections
C0398623 BXGD008202 Thrombophilia Hemic and Lymphatic Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1096245 BXGD011611 Gait deviation
C1264039 BXGD011909 von Willebrand Disease, Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1445957 BXGD013081 Serum total cholesterol measurement
C1458140 BXGD013134 Bleeding tendency Hemic and Lymphatic Diseases
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1837658 BXGD014257 Gross motor development delay Mental Disorders
C1848534 BXGD014937 VITAMIN K-DEPENDENT CLOTTING FACTORS, COMBINED DEFICIENCY OF, 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1848641 BXGD014955 Profound sensorineural hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1969572 BXGD016781 Prolonged bleeding after dental extraction
C2732267 BXGD017551 Auditory neuropathy spectrum disorder Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4317093 BXGD022723 Reduced factor XI activity
C4321502 BXGD022753 Factor XI Deficiency
C4524088 BXGD023091 Patella baja
C4527149 BXGD023152 Intermediate Atypical Prostate Carcinoma
C4699512 BXGD023639 Large-artery atherosclerosis (embolus/thrombosis)
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000279 L-Alanine 89.09
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000989 Glutathione 307.32
BXGC0003705 Chloride 35.45
BXGC0004763 Octopamine 153.18
BXGC0006198 Citric acid 192.12
BXGC0008969 Eduleine 265.31
BXGC0012913 Pentagalloyl Glucose 940.12
BXGC0016421 punicalin 782.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein