Showing entry for Bifunctional glutamate/proline--tRNA ligase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006680
Protein NameBifunctional glutamate/proline--tRNA ligase
Uniport IdP07814
GeneEPRS1
Gene Id2058
DomainGST_C; HGTP_anticodon; ProRS-C_1; tRNA-synt_1c; tRNA-synt_1c_C; tRNA-synt_2b; WHEP-TRS
Pfam PF00043   PF03129   PF09180   PF00749   PF03950   PF00587   PF00458  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00860 Porphyrin and chlorophyll metabolism
2. Genetic Information Processing 2.2 Translation hsa00970 Aminoacyl-tRNA biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0071346 cellular response to interferon-gamma
Biological Process GO:0006424 glutamyl-tRNA aminoacylation
Biological Process GO:0017148 negative regulation of translation
Biological Process GO:0006433 prolyl-tRNA aminoacylation
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0140212 regulation of long-chain fatty acid import into cell
Biological Process GO:0006418 tRNA aminoacylation for protein translation
molecular function GO:0005524 ATP binding
molecular function GO:0004818 glutamate-tRNA ligase activity
molecular function GO:0051020 GTPase binding
molecular function GO:0042802 identical protein binding
molecular function GO:0004827 proline-tRNA ligase activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0035613 RNA stem-loop binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0097452 GAIT complex
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:1990904 ribonucleoprotein complex
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-2408522 Selenoamino acid metabolism
R-HSA-379716 Cytosolic tRNA aminoacylation
R-HSA-379724 tRNA Aminoacylation
R-HSA-392499 Metabolism of proteins
R-HSA-6782315 tRNA modification in the nucleus and cytosol
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-72306 tRNA processing
R-HSA-72766 Translation
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002418 BXGD000112 Amblyopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004158 BXGD000261 Athetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008055 BXGD000514 Chikungunya Fever Infections
C0009187 BXGD000591 Coccidiosis Infections
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0020490 BXGD001403 Hyperopia Eye Diseases
C0023520 BXGD001678 Leukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038586 BXGD002772 Substance Use Disorders Chemically-Induced Disorders; Mental Disorders
C0042164 BXGD002965 Uveitis Eye Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152021 BXGD003520 Congenital heart disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0206161 BXGD004167 Reticulocyte count (procedure)
C0232466 BXGD004543 Feeding difficulties
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234376 BXGD004659 Action Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242852 BXGD005197 Proliferative vitreoretinopathy Eye Diseases
C0275524 BXGD006376 Coinfection Infections
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0343401 BXGD007623 MRSA - Methicillin resistant Staphylococcus aureus infection Infections
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0878787 BXGD011392 Growth failure
C1096063 BXGD011600 Drug Resistant Epilepsy Nervous System Diseases
C1299919 BXGD012267 Enteric coccidiosis Digestive System Diseases; Infections
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1836830 BXGD014165 Developmental regression Mental Disorders
C1839364 BXGD014371 Progressive visual loss
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2677112 BXGD017363 Leukodystrophy, hypomyelinating
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C4553743 BXGD023548 Spasticity, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4693733 BXGD023614 LEUKODYSTROPHY, HYPOMYELINATING, 15
C4733092 BXGD023907 estrogen receptor-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000288 L-Proline 115.13
BXGC0002588 Magnesium 24.31
BXGC0002605 Adenosine 267.24
BXGC0006162 L-Glutamic acid 147.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein