Showing entry for Heat shock protein HSP 90-beta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006753
Protein NameHeat shock protein HSP 90-beta
Uniport IdP08238
GeneHSP90AB1
Gene Id3326
DomainHATPase_c; HSP90
Pfam PF02518   PF00183  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04217 Necroptosis
5. Organismal Systems 5.1 Immune system hsa04612 Antigen processing and presentation
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04657 IL-17 signaling pathway
5. Organismal Systems 5.1 Immune system hsa04659 Th17 cell differentiation
5. Organismal Systems 5.2 Endocrine system hsa04914 Progesterone-mediated oocyte maturation
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05215 Prostate cancer
6. Human Diseases 6.6 Cardiovascular diseases hsa05418 Fluid shear stress and atherosclerosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0048675 axon extension
Biological Process GO:0035690 cellular response to drug
Biological Process GO:0034605 cellular response to heat
Biological Process GO:0071353 cellular response to interleukin-4
Biological Process GO:0071407 cellular response to organic cyclic compound
Biological Process GO:0021955 central nervous system neuron axonogenesis
Biological Process GO:0051131 chaperone-mediated protein complex assembly
Biological Process GO:0030010 establishment of cell polarity
Biological Process GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
Biological Process GO:0071157 negative regulation of cell cycle arrest
Biological Process GO:1903660 negative regulation of complement-dependent cytotoxicity
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:1901799 negative regulation of proteasomal protein catabolic process
Biological Process GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0051248 negative regulation of protein metabolic process
Biological Process GO:1901389 negative regulation of transforming growth factor beta activation
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0001890 placenta development
Biological Process GO:0045597 positive regulation of cell differentiation
Biological Process GO:0045793 positive regulation of cell size
Biological Process GO:1904031 positive regulation of cyclin-dependent protein kinase activity
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0032516 positive regulation of phosphoprotein phosphatase activity
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:0042307 positive regulation of protein import into nucleus
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:2000010 positive regulation of protein localization to cell surface
Biological Process GO:0071902 positive regulation of protein serine/threonine kinase activity
Biological Process GO:1902949 positive regulation of tau-protein kinase activity
Biological Process GO:0051973 positive regulation of telomerase activity
Biological Process GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0006457 protein folding
Biological Process GO:0050821 protein stabilization
Biological Process GO:1903827 regulation of cellular protein localization
Biological Process GO:1900034 regulation of cellular response to heat
Biological Process GO:0060334 regulation of interferon-gamma-mediated signaling pathway
Biological Process GO:0031396 regulation of protein ubiquitination
Biological Process GO:0060338 regulation of type I interferon-mediated signaling pathway
Biological Process GO:0042220 response to cocaine
Biological Process GO:0009651 response to salt stress
Biological Process GO:0006986 response to unfolded protein
Biological Process GO:0097435 supramolecular fiber organization
Biological Process GO:1905323 telomerase holoenzyme complex assembly
Biological Process GO:0007004 telomere maintenance via telomerase
Biological Process GO:0019062 virion attachment to host cell
Biological Process GO:0006805 xenobiotic metabolic process
molecular function GO:0005524 ATP binding
molecular function GO:0043008 ATP-dependent protein binding
molecular function GO:0045296 cadherin binding
molecular function GO:0002135 CTP binding
molecular function GO:0032564 dATP binding
molecular function GO:0097718 disordered domain specific binding
molecular function GO:0070182 DNA polymerase binding
molecular function GO:0003725 double-stranded RNA binding
molecular function GO:0008144 drug binding
molecular function GO:0005525 GTP binding
molecular function GO:0031072 heat shock protein binding
molecular function GO:0042826 histone deacetylase binding
molecular function GO:1990226 histone methyltransferase binding
molecular function GO:0042802 identical protein binding
molecular function GO:0044325 ion channel binding
molecular function GO:0019900 kinase binding
molecular function GO:0023026 MHC class II protein complex binding
molecular function GO:0030235 nitric-oxide synthase regulator activity
molecular function GO:0042277 peptide binding
molecular function GO:0046983 protein dimerization activity
molecular function GO:0044183 protein folding chaperone
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0019887 protein kinase regulator activity
molecular function GO:0003723 RNA binding
molecular function GO:0017098 sulfonylurea receptor binding
molecular function GO:0048156 tau protein binding
molecular function GO:0030911 TPR domain binding
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0051082 unfolded protein binding
molecular function GO:0002134 UTP binding
cellular component GO:0016324 apical plasma membrane
cellular component GO:0034751 aryl hydrocarbon receptor complex
cellular component GO:0044295 axonal growth cone
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0031526 brush border membrane
cellular component GO:0009986 cell surface
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0044294 dendritic growth cone
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:1990565 HSP90-CDC37 chaperone complex
cellular component GO:0016234 inclusion body
cellular component GO:0005765 lysosomal membrane
cellular component GO:0042470 melanosome
cellular component GO:0016020 membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0043025 neuronal cell body
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:1990917 ooplasm
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
cellular component GO:0034774 secretory granule lumen
cellular component GO:1990913 sperm head plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-211859 Biological oxidations
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-2262752 Cellular responses to stress
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-3371511 HSF1 activation
R-HSA-3371556 Cellular response to heat stress
R-HSA-3371568 Attenuation phase
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-373755 Semaphorin interactions
R-HSA-399954 Sema3A PAK dependent Axon repulsion
R-HSA-422475 Axon guidance
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-5336415 Uptake and function of diphtheria toxin
R-HSA-5339562 Uptake and actions of bacterial toxins
R-HSA-5663205 Infectious disease
R-HSA-622312 Inflammasomes
R-HSA-6798695 Neutrophil degranulation
R-HSA-69275 G2/M Transition
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-844456 The NLRP3 inflammasome
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8937144 Aryl hydrocarbon receptor signalling
R-HSA-8939211 ESR-mediated signaling
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-9612973 Autophagy
R-HSA-9613829 Chaperone Mediated Autophagy
R-HSA-9658195 Leishmania infection
R-HSA-9660826 Purinergic signaling in leishmaniasis infection
R-HSA-9664424 Cell recruitment (pro-inflammatory response)
R-HSA-9675108 Nervous system development
R-HSA-9679191 Potential therapeutics for SARS
R-HSA-9679506 SARS-CoV Infections
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007130 BXGD000440 Mucinous Adenocarcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014057 BXGD000880 Japanese Encephalitis Infections; Nervous System Diseases
C0014060 BXGD000882 Encephalitis, St. Louis Infections; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014553 BXGD000931 Absence Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024232 BXGD001751 Lymphatic Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026846 BXGD001939 Muscular Atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0080032 BXGD003105 Pleural Effusion, Malignant Neoplasms; Respiratory Tract Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0154251 BXGD003710 Lipid Metabolism Disorders Nutritional and Metabolic Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0577631 BXGD009535 Carotid Atherosclerosis Nervous System Diseases; Cardiovascular Diseases
C0595989 BXGD009632 Carcinoma of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1611743 BXGD013456 Familial (FPAH)
C1709527 BXGD013626 B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1841972 BXGD014484 Glucocorticoid Receptor Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1851585 BXGD015222 MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C4505456 BXGD022964 HIV Coinfection Infections; Immune System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4733092 BXGD023907 estrogen receptor-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000019 ent-Gallocatechin 3-gallate 458.37
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0001545 Harmine 212.25
BXGC0001789 Silibinin 482.44
BXGC0001857 Caffeic acid 180.16
BXGC0002588 Magnesium 24.31
BXGC0003396 Legumelin 394.42
BXGC0004275 Acetaldehyde 44.05
BXGC0004965 Rhein 284.22
BXGC0005682 3,3',4,4'-Tetrahydroxylignan 302.36
BXGC0005683 Quercetin 302.24
BXGC0006306 Myricetin 318.24
BXGC0013881 Cucurbitacin I 514.29
BXGC0014048 Celastrol 450.28
BXGC0014164 9-fluorenone 180.06
BXGC0020368 Gambogic Acid 628.3
BXGC0023872 Adenine 135.05
BXGC0024132 1H-Indol-5-Ol 133.05
BXGC0025767 23,24-Dihydrocucurbitacin B 560.33
BXGC0027544 Gedunin 482.23
BXGC0029271 Cucurbitacin E 556.3
BXGC0031717 Purpurin 256.04
BXGC0033310 Epigalocatechin Gallate 458.08
BXGC0039476 Eriodictyol 288.06
BXGC0040687 Aicar 338.06
BXGC0041885 Cucurbitacin D 516.31
BXGC0042127 Oxyquinoline 145.05
BXGC0046281 Cucurbitacin B 558.32
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein