Showing entry for 3,3',4,4'-Tetrahydroxylignan


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0005682
Compound Name3,3',4,4'-Tetrahydroxylignan
Structure
FormulaC18H22O4
InchiKeyHCZKYJDFEPMADG-UHFFFAOYSA-N
SMILESCC(CC1=CC(O)=C(O)C=C1)C(C)CC1=CC=C(O)C(O)=C1
InchiInChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
IUPAC4-[(2S,3S)-3-[(3,4-dihydroxyphenyl)methyl]-2-methylbutyl]benzene-1,2-diol
Molecular Weight302.36
Pubchem Id4534
Chembl IdCHEMBL52
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 32020
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006696 Heat shock protein HSP 90-alpha reviewed Chaperone HSP90AA1 - 2623.2 - -
reviewed BXGT006234 Gag-Pol polyprotein reviewed gag-pol - 663.999975 - -
reviewed BXGT011400 14-3-3 protein gamma reviewed Chaperone YWHAG - >50000 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 22193.67 - -
reviewed BXGT006696 Heat shock protein HSP 90-alpha reviewed Chaperone HSP90AA1 - >30000 - -
reviewed BXGT022194 Zinc finger protein mex-5 reviewed mex-5 - - - 8755
reviewed BXGT006016 Large T antigen reviewed - - 21860 - -
reviewed BXGT010049 Heat shock factor protein 1 reviewed Hsf1 - - - 2319
reviewed BXGT007701 Glucose-6-phosphate 1-dehydrogenase reviewed Enzyme G6PD - >80000 - -
reviewed BXGT009349 Caspase-1 reviewed Enzyme CASP1 - >1.0e+4 - -
reviewed BXGT006736 Seed linoleate 13S-lipoxygenase-1 reviewed LOX1.1 - 32700 - -
reviewed BXGT013590 Leukotriene B4 receptor 1 reviewed G-protein coupled receptor LTB4R - 85 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 400 - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - 160 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 300 - -
reviewed BXGT016082 Prostaglandin G/H synthase 1 reviewed Ptgs1 - >50000 - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - 85 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 100 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 120 - -
reviewed BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 - 110 - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - 500 - -
reviewed BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B - 11000 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 410 - -
reviewed BXGT005953 Transthyretin reviewed Transporter TTR - - - 8500
reviewed BXGT005953 Transthyretin reviewed Transporter TTR - - - 12600
reviewed BXGT005953 Transthyretin reviewed Transporter TTR - - - 7300
reviewed BXGT006736 Seed linoleate 13S-lipoxygenase-1 reviewed LOX1.1 - 1300 - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - 130 - -
reviewed BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 - 250 - -
reviewed BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 - 2600 - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - 35000 - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - 380 - -
reviewed BXGT004924 Prostaglandin G/H synthase 1 reviewed PTGS1 - 50000 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - >50000 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 500 - -
reviewed BXGT008947 Seed linoleate 9S-lipoxygenase reviewed LOX1.4 - 400000 - -
CHEMBL CHEMBL52
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 39810 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 10000 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 100 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 Inhibition '=' 60 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 1678 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 2818 nM
Q9XUB2 BXGT022194 Zinc finger protein mex-5 reviewed - mex-5 EC50 '=' 8755 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 IC50 '=' 250 nM
Q39829 BXGT014381 Lipoxygenase unreviewed - Inhibition '=' 84 %
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 IC50 '=' 5900 nM
Q14191 BXGT013452 Werner syndrome ATP-dependent helicase reviewed Enzyme WRN Potency - 17782 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 Inhibition - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 12589 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 15848 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 19952 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 130 nM
P02766 BXGT005953 Transthyretin reviewed Transporter TTR EC50 '=' 8500 nM
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 5011 nM
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase reviewed Enzyme G6PD IC50 '>' 80000 nM
P24095 BXGT008947 Seed linoleate 9S-lipoxygenase reviewed - LOX1.4 Inhibition '=' 12 %
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 28183 nM
P08238 BXGT006753 Heat shock protein HSP 90-beta reviewed Chaperone HSP90AB1 IC50 '=' 2623 nM
P07900 BXGT006696 Heat shock protein HSP 90-alpha reviewed Chaperone HSP90AA1 IC50 '=' 2623 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 25 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 IC50 '=' 110 nM
P80244 BXGT011887 ATP-dependent Clp protease proteolytic subunit reviewed - clpP Potency - 631 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 22193 nM
P08170 BXGT006736 Seed linoleate 13S-lipoxygenase-1 reviewed - LOX1.1 IC50 '=' 31300 nM
P11511 BXGT007717 Aromatase reviewed Enzyme CYP19A1 IC50 '=' 11 nM
P02766 BXGT005953 Transthyretin reviewed Transporter TTR Inhibition '<' 20 %
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 5000 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 IC50 '=' 1100 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 12589 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 14125 nM
P38532 BXGT010049 Heat shock factor protein 1 reviewed - Hsf1 EC50 '=' 2319 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 160 nM
Q9BHT9 BXGT020096 Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase unreviewed - G6PD-6PGL IC50 '=' 29200 nM
O95398 BXGT005378 Rap guanine nucleotide exchange factor 3 reviewed Enzyme modulator RAPGEF3 Potency - 50118 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 IC50 '=' 2600 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR IC50 '>' 10000 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B IC50 '=' 11000 nM
Q63921 BXGT016082 Prostaglandin G/H synthase 1 reviewed - Ptgs1 IC50 '>' 50000 nM
P35355 BXGT009817 Prostaglandin G/H synthase 2 reviewed - Ptgs2 IC50 '>' 50000 nM
Q57TT1 BXGT015153 Uncharacterized protein unreviewed - Tb927.8.6820 Potency - 15848 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 IC50 '=' 3800 nM
P01100 BXGT005727 Proto-oncogene c-Fos reviewed Transcription factor FOS IC50 '=' 7 nM
P05412 BXGT006354 Transcription factor AP-1 reviewed Transcription factor JUN IC50 '=' 7 nM
Q15722 BXGT013590 Leukotriene B4 receptor 1 reviewed G-protein coupled receptor LTB4R IC50 '=' 85 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 3162 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Potency '=' 14125 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 410 nM
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short reviewed - GNAS Potency - 50118 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 1584 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 500 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 79432 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 39810 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 39810 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 9074 nM
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 '=' 110 nM
P61981 BXGT011400 14-3-3 protein gamma reviewed Chaperone YWHAG IC50 '>' 50000 nM
P08170 BXGT006736 Seed linoleate 13S-lipoxygenase-1 reviewed - LOX1.1 IC50 '>' 10000 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Inhibition - - -
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 400 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Inhibition - - -
P08170 BXGT006736 Seed linoleate 13S-lipoxygenase-1 reviewed - LOX1.1 IC50 '=' 3500 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 500 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 22387 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 110 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 120 nM
P02766 BXGT005953 Transthyretin reviewed Transporter TTR Activity - - -
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 17782 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 22387 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Inhibition '=' 10 %
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 44668 nM
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 25118 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 25118 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 100 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 44668 nM
P08170 BXGT006736 Seed linoleate 13S-lipoxygenase-1 reviewed - LOX1.1 Inhibition '=' 94 %
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 IC50 '=' 4900 nM
P08170 BXGT006736 Seed linoleate 13S-lipoxygenase-1 reviewed - LOX1.1 Inhibition '=' 83 %
Q9BHT9 BXGT020096 Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase unreviewed - G6PD-6PGL IC50 '=' 54900 nM
P24095 BXGT008947 Seed linoleate 9S-lipoxygenase reviewed - LOX1.4 IC50 '=' 400000 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 17782 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 20596 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 44668 nM
G5EF15 BXGT003524 Cytoplasmic zinc-finger protein unreviewed - pos-1 EC50 '=' 26111 nM
Q63921 BXGT016082 Prostaglandin G/H synthase 1 reviewed - Ptgs1 IC50 '=' 30000 nM
P35355 BXGT009817 Prostaglandin G/H synthase 2 reviewed - Ptgs2 IC50 '=' 30000 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 300 nM
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 IC50 '=' 5500 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 891 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 28183 nM
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 22334 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Activity '=' 0 %
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 31622 nM
P08238 BXGT006753 Heat shock protein HSP 90-beta reviewed Chaperone HSP90AB1 IC50 '>' 30000 nM
P07900 BXGT006696 Heat shock protein HSP 90-alpha reviewed Chaperone HSP90AA1 IC50 '>' 30000 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Activity '=' 10 %
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 IC50 '=' 180 nM
P9WH09 BXGT012284 dTDP-4-dehydrorhamnose reductase reviewed - rmlD Inhibition - - -
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 10000 nM
P48999 BXGT010669 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 400 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR IC50 '>' 50000 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR IC50 '=' 38800 nM
P08170 BXGT006736 Seed linoleate 13S-lipoxygenase-1 reviewed - LOX1.1 IC50 '=' 1300 nM
Q9BEG3 BXGT020092 5-lipoxygenase unreviewed - IC50 '=' 400 nM
Q9BEG3 BXGT020092 5-lipoxygenase unreviewed - IC50 '=' 1000 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 35481 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 56234 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '>' 50000 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 150 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 10 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Activity - - -
O62664 BXGT004924 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 50000 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 39810 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 140 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 EC50 '>' 100 mg kg-1
P08170 BXGT006736 Seed linoleate 13S-lipoxygenase-1 reviewed - LOX1.1 IC50 '=' 180 nM
K4CF70 BXGT026101 Fatty acid hydroperoxide lyase, chloroplastic reviewed - HPL IC50 '=' 50000 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 120 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Inhibition '=' 0 %
Q39829 BXGT014381 Lipoxygenase unreviewed - IC50 '=' 9230 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 Inhibition '=' 70 %
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 22387 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 IC50 '=' 5100 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 5623 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 Inhibition '=' 73 %
O49150 BXGT004652 Lipoxygenase unreviewed - IC50 '>' 10000 nM
Q57TT1 BXGT015153 Uncharacterized protein unreviewed - Tb927.8.6820 Potency - 44668 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 10000 nM
P08069 BXGT006723 Insulin-like growth factor 1 receptor reviewed Kinase IGF1R IC50 '=' 900 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 25118 nM
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 39810 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 39810 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 1500 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 15848 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 85 nM
Q9BHT9 BXGT020096 Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase unreviewed - G6PD-6PGL IC50 '=' 68400 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 366 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 31622 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 22387 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 Inhibition '=' 56 %
Q39829 BXGT014381 Lipoxygenase unreviewed - Activity '=' 83 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 2985 nM
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 22370 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Inhibition '=' 0 %
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Activity '=' 0 %
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Inhibition - - -
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 11220 nM
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 8087 nM
O62664 BXGT004924 Prostaglandin G/H synthase 1 reviewed - PTGS1 Inhibition '=' 31 %
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Activity '=' 23 %
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 44668 nM
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 12589 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 Inhibition '=' 0 %
Q39829 BXGT014381 Lipoxygenase unreviewed - Inhibition '=' 40 %
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 IC50 '=' 5100 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 IC50 '=' 110 nM
P02766 BXGT005953 Transthyretin reviewed Transporter TTR EC50 '=' 12600 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 39810 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Activity '=' 1 %
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 7943 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
Q39829 BXGT014381 Lipoxygenase unreviewed - IC50 '=' 51000 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Inhibition - - -
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 2818 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 22387 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 89125 nM
P02766 BXGT005953 Transthyretin reviewed Transporter TTR EC50 '=' 7300 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 380 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 794 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Activity - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 5011 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 2238 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 6513 nM
O62698 BXGT004925 Prostaglandin G/H synthase 2 reviewed - PTGS2 IC50 '=' 14000 nM
O62664 BXGT004924 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 14000 nM
P08170 BXGT006736 Seed linoleate 13S-lipoxygenase-1 reviewed - LOX1.1 Inhibition - - -
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 35000 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 12589 nM
Q39829 BXGT014381 Lipoxygenase unreviewed - IC50 '=' 28000 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 IC50 '=' 5000 nM
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 28183 nM
P03070 BXGT006016 Large T antigen reviewed - IC50 - 21860 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Inhibition '=' 0 %
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 100 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB IC50 - - -
P37059 BXGT009957 Estradiol 17-beta-dehydrogenase 2 reviewed Enzyme HSD17B2 IC50 '=' 380 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00101 Flaxseed Linum usitatissimum Herbs and Spices
BXGF05977 Schisandra chinensis Schisandra chinensis Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease