Showing entry for Tropomyosin alpha-1 chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006900
Protein NameTropomyosin alpha-1 chain
Uniport IdP09493
GeneTPM1
Gene Id7168
DomainTropomyosin
Pfam PF00261  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
6. Human Diseases 6.1 Cancers: Overview hsa05206 MicroRNAs in cancer
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007015 actin filament organization
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0034614 cellular response to reactive oxygen species
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0006936 muscle contraction
Biological Process GO:0030049 muscle filament sliding
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:1904753 negative regulation of vascular associated smooth muscle cell migration
Biological Process GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
Biological Process GO:0032781 positive regulation of ATPase activity
Biological Process GO:0045785 positive regulation of cell adhesion
Biological Process GO:0003065 positive regulation of heart rate by epinephrine
Biological Process GO:0051496 positive regulation of stress fiber assembly
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0008016 regulation of heart contraction
Biological Process GO:0006937 regulation of muscle contraction
Biological Process GO:0031529 ruffle organization
Biological Process GO:0045214 sarcomere organization
Biological Process GO:0055010 ventricular cardiac muscle tissue morphogenesis
Biological Process GO:0042060 wound healing
molecular function GO:0003779 actin binding
molecular function GO:0051015 actin filament binding
molecular function GO:0008092 cytoskeletal protein binding
molecular function GO:0042802 identical protein binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0005200 structural constituent of cytoskeleton
molecular function GO:0008307 structural constituent of muscle
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0005884 actin filament
cellular component GO:0032059 bleb
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0005862 muscle thin filament tropomyosin
cellular component GO:0032587 ruffle membrane
cellular component GO:0030017 sarcomere
cellular component GO:0001725 stress fiber
Reactome
Pathway Id Pathway Name
R-HSA-390522 Striated Muscle Contraction
R-HSA-397014 Muscle contraction
R-HSA-445355 Smooth Muscle Contraction
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003851 BXGD000226 Arteriosclerosis Obliterans Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013481 BXGD000846 Ebstein Anomaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022548 BXGD001551 Keloid Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0023787 BXGD001698 Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032181 BXGD002332 Platelet Count measurement
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0039685 BXGD002825 Tetralogy of Fallot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0042514 BXGD002989 Tachycardia, Ventricular Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0158646 BXGD003897 Cleft palate with cleft lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200665 BXGD004045 Platelet mean volume determination (procedure)
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0206157 BXGD004165 Myopathies, Nemaline Musculoskeletal Diseases; Nervous System Diseases
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0234119 BXGD004622 Neuromuscular inhibition
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0262659 BXGD005265 Vagina Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279680 BXGD006680 Transitional cell carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0340425 BXGD007328 Hypertrophic cardiomyopathy without obstruction Cardiovascular Diseases
C0340427 BXGD007329 Familial dilated cardiomyopathy Cardiovascular Diseases
C0344975 BXGD007712 Pulmonary Atresia with Intact Ventricular Septum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0349788 BXGD007956 Arrhythmogenic Right Ventricular Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0427460 BXGD008616 Red cell distribution width determination
C0427515 BXGD008619 Neutrophil abnormality
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0476403 BXGD008992 Electromyogram abnormal
C0521158 BXGD009130 Recurrent tumor
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0597124 BXGD009651 Obstructive asymmetric septal hypertrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0700053 BXGD009873 Idiopathic hypertrophic subaortic stenosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0751656 BXGD010540 Nemaline Myopathy, Autosomal Dominant Musculoskeletal Diseases; Nervous System Diseases
C0751657 BXGD010541 Nemaline Myopathy, Autosomal Recessive Musculoskeletal Diseases; Nervous System Diseases
C0810364 BXGD010846 Cleft Lip with or without Cleft Palate
C0877015 BXGD011327 Pelvic Organ Prolapse Pathological Conditions, Signs and Symptoms
C0877854 BXGD011362 Cerebral Arteriosclerosis Nervous System Diseases; Cardiovascular Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0949658 BXGD011582 Cardiomyopathy, Hypertrophic, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1280433 BXGD012125 Lipoatrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1445957 BXGD013081 Serum total cholesterol measurement
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1533847 BXGD013318 Disorder of skeletal muscle Musculoskeletal Diseases; Nervous System Diseases
C1611743 BXGD013456 Familial (FPAH)
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1861863 BXGD016085 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 3 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1862389 BXGD016126 ATRIAL SEPTAL DEFECT 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1960469 BXGD016664 Left ventricular noncompaction Cardiovascular Diseases
C2678476 BXGD017415 Cardiomyopathy, Dilated, 1y Cardiovascular Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3710589 BXGD019375 Cap Myopathy Musculoskeletal Diseases; Nervous System Diseases
C3805278 BXGD019474 Extrahepatic Cholangiocarcinoma Neoplasms
C3808145 BXGD019540 LEFT VENTRICULAR NONCOMPACTION 9
C3828530 BXGD019744 Platelet Component Distribution Width Measurement
C4021133 BXGD020563 Left ventricular noncompaction cardiomyopathy Pathological Conditions, Signs and Symptoms
C4025298 BXGD021632 Effort-induced polymorphic ventricular tachycardias Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C4284013 BXGD022428 Primary cholangiocarcinoma of intrahepatic biliary tract Neoplasms
C4324548 BXGD022769 Non-compaction cardiomyopathy Cardiovascular Diseases
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
C4551675 BXGD023384 Keratoderma, Palmoplantar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4732796 BXGD023903 Apical hypertrophic cardiomyopathy Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002953 2-Phenethyl isothiocyanate 163.24
BXGC0051100 dihydroartemisinin 284.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein