Showing entry for Heat shock cognate 71 kDa protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007658
Protein NameHeat shock cognate 71 kDa protein
Uniport IdP11142
GeneHSPA8
Gene Id3312
DomainHSP70
Pfam PF00012  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.1 Transcription hsa03040 Spliceosome
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
5. Organismal Systems 5.9 Aging hsa04213 Longevity regulating pathway - multiple species
5. Organismal Systems 5.1 Immune system hsa04612 Antigen processing and presentation
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05134 Legionellosis
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05145 Toxoplasmosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05162 Measles
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0046034 ATP metabolic process
Biological Process GO:0008088 axo-dendritic transport
Biological Process GO:0009267 cellular response to starvation
Biological Process GO:0034620 cellular response to unfolded protein
Biological Process GO:0051085 chaperone cofactor-dependent protein refolding
Biological Process GO:0061684 chaperone-mediated autophagy
Biological Process GO:1904764 chaperone-mediated autophagy translocation complex disassembly
Biological Process GO:0061741 chaperone-mediated protein transport involved in chaperone-mediated autophagy
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0061738 late endosomal microautophagy
Biological Process GO:0061024 membrane organization
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:1902904 negative regulation of supramolecular fiber organization
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0007269 neurotransmitter secretion
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0044829 positive regulation by host of viral genome replication
Biological Process GO:0048026 positive regulation of mRNA splicing, via spliceosome
Biological Process GO:0006457 protein folding
Biological Process GO:0042026 protein refolding
Biological Process GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:1900034 regulation of cellular response to heat
Biological Process GO:0043488 regulation of mRNA stability
Biological Process GO:0099175 regulation of postsynapse organization
Biological Process GO:0061635 regulation of protein complex stability
Biological Process GO:0043254 regulation of protein-containing complex assembly
Biological Process GO:1904589 regulation of protein import
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:0006986 response to unfolded protein
Biological Process GO:1990832 slow axonal transport
Biological Process GO:0016192 vesicle-mediated transport
Biological Process GO:0016032 viral process
molecular function GO:0016887 ATPase activity
molecular function GO:0005524 ATP binding
molecular function GO:0055131 C3HC4-type RING finger domain binding
molecular function GO:0045296 cadherin binding
molecular function GO:0051087 chaperone binding
molecular function GO:1990833 clathrin-uncoating ATPase activity
molecular function GO:0019899 enzyme binding
molecular function GO:0001664 G protein-coupled receptor binding
molecular function GO:0031072 heat shock protein binding
molecular function GO:0023026 MHC class II protein complex binding
molecular function GO:0051787 misfolded protein binding
molecular function GO:0001786 phosphatidylserine binding
molecular function GO:0044183 protein folding chaperone
molecular function GO:0030674 protein-macromolecule adaptor activity
molecular function GO:0003723 RNA binding
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0051082 unfolded protein binding
cellular component GO:0005776 autophagosome
cellular component GO:0030424 axon
cellular component GO:0072562 blood microparticle
cellular component GO:0101031 chaperone complex
cellular component GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0030425 dendrite
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0005925 focal adhesion
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005770 late endosome
cellular component GO:0098575 lumenal side of lysosomal membrane
cellular component GO:0043202 lysosomal lumen
cellular component GO:0005765 lysosomal membrane
cellular component GO:0005764 lysosome
cellular component GO:0042470 melanosome
cellular component GO:0016020 membrane
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0098684 photoreceptor ribbon synapse
cellular component GO:0005886 plasma membrane
cellular component GO:0099524 postsynaptic cytosol
cellular component GO:0099523 presynaptic cytosol
cellular component GO:0000974 Prp19 complex
cellular component GO:1990904 ribonucleoprotein complex
cellular component GO:0034774 secretory granule lumen
cellular component GO:0005681 spliceosomal complex
cellular component GO:0043195 terminal bouton
Reactome
Pathway Id Pathway Name
R-HSA-112310 Neurotransmitter release cycle
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1266738 Developmental Biology
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1632852 Macroautophagy
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-199991 Membrane Trafficking
R-HSA-199992 trans-Golgi Network Vesicle Budding
R-HSA-2262752 Cellular responses to stress
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-3371556 Cellular response to heat stress
R-HSA-3371568 Attenuation phase
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-373760 L1CAM interactions
R-HSA-392499 Metabolism of proteins
R-HSA-422475 Axon guidance
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-447041 CHL1 interactions
R-HSA-449147 Signaling by Interleukins
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
R-HSA-5653656 Vesicle-mediated transport
R-HSA-597592 Post-translational protein modification
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695 Neutrophil degranulation
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72172 mRNA Splicing
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8876725 Protein methylation
R-HSA-888590 GABA synthesis, release, reuptake and degradation
R-HSA-8953854 Metabolism of RNA
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9612973 Autophagy
R-HSA-9613354 Lipophagy
R-HSA-9613829 Chaperone Mediated Autophagy
R-HSA-9615710 Late endosomal microautophagy
R-HSA-9663891 Selective autophagy
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0006840 BXGD000409 Candidiasis Infections
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0008354 BXGD000533 Cholera Infections
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014378 BXGD000912 Enterovirus Infections Infections
C0015230 BXGD000969 Exanthema Skin and Connective Tissue Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016085 BXGD001047 Filariasis Infections
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024302 BXGD001760 Reticulosarcoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026640 BXGD001912 Mouth Neoplasms Neoplasms; Stomatognathic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026850 BXGD001942 Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027962 BXGD002064 Melanocytic nevus Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0034494 BXGD002481 Rabies (disorder) Infections
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0035869 BXGD002569 Rotavirus Infections Infections
C0036117 BXGD002577 Salmonella infections Infections
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0042769 BXGD002999 Virus Diseases Infections
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0153567 BXGD003665 Uterine Cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0162557 BXGD003956 Liver Failure, Acute Digestive System Diseases
C0205641 BXGD004093 Adenocarcinoma, Basal Cell Neoplasms
C0205642 BXGD004094 Adenocarcinoma, Oxyphilic Neoplasms
C0205643 BXGD004095 Carcinoma, Cribriform Neoplasms
C0205644 BXGD004096 Carcinoma, Granular Cell Neoplasms
C0205645 BXGD004097 Adenocarcinoma, Tubular Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0271829 BXGD006267 Pendred's syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Endocrine System Diseases; Otorhinolaryngologic Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279671 BXGD006677 Cervical Squamous Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0282666 BXGD006824 Very Low Birth Weight
C0334663 BXGD007149 Histiocytic sarcoma Neoplasms; Hemic and Lymphatic Diseases
C0338614 BXGD007208 Psychotic episodes Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392663 BXGD008061 Infection by Wuchereria bancrofti Infections; Hemic and Lymphatic Diseases
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751337 BXGD010393 X-Linked Emery-Dreifuss Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0848332 BXGD010879 Spots on skin Skin and Connective Tissue Diseases
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0860594 BXGD011234 Malignant melanoma, metastatic Neoplasms
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1269955 BXGD012005 Tumor Cell Invasion
C1275278 BXGD012074 Extraskeletal Myxoid Chondrosarcoma Neoplasms
C1281914 BXGD012135 Corneal allograft rejection
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1706731 BXGD013576 Adult Extraskeletal Myxoid Chondrosarcoma Neoplasms
C1708349 BXGD013597 Hereditary Diffuse Gastric Cancer Digestive System Diseases; Neoplasms
C1846707 BXGD014836 SPINOCEREBELLAR ATAXIA 17 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2609414 BXGD017182 Acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2673697 BXGD017222 Dystonia with Cerebellar Atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3178817 BXGD018544 Paraneoplastic Syndromes, Ocular Neoplasms; Eye Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3665593 BXGD019294 Melanocytic nevus of skin Neoplasms
C3714514 BXGD019409 Infection Infections
C4014261 BXGD020138 SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 16 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4529962 BXGD023178 Fatty Liver Disease
C4551649 BXGD023382 Congenital Dysplasia Of The Hip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0002588 Magnesium 24.31
BXGC0002605 Adenosine 267.24
BXGC0002616 Copper 63.55
BXGC0003705 Chloride 35.45
BXGC0006193 Ellagic acid 302.19
BXGC0018477 Cryptopleurine 377.2
BXGC0020680 Mandelic Acid 152.05
BXGC0021676 Withaferin A 470.27
BXGC0023872 Adenine 135.05
BXGC0044624 Betaine 118.09
BXGC0049447 acetate 59.01
BXGC0051100 dihydroartemisinin 284.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein