Showing entry for Glypican-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009788
Protein NameGlypican-1
Uniport IdP35052
GeneGPC1
Gene Id2817
DomainGlypican
Pfam PF01153  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
6. Human Diseases 6.6 Cardiovascular diseases hsa05418 Fluid shear stress and atherosclerosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007411 axon guidance
Biological Process GO:0016477 cell migration
Biological Process GO:0006024 glycosaminoglycan biosynthetic process
Biological Process GO:0006027 glycosaminoglycan catabolic process
Biological Process GO:0030200 heparan sulfate proteoglycan catabolic process
Biological Process GO:0050900 leukocyte migration
Biological Process GO:0032288 myelin assembly
Biological Process GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
Biological Process GO:2001016 positive regulation of skeletal muscle cell differentiation
Biological Process GO:1905475 regulation of protein localization to membrane
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0014037 Schwann cell differentiation
molecular function GO:0005507 copper ion binding
molecular function GO:0017134 fibroblast growth factor binding
molecular function GO:0043236 laminin binding
cellular component GO:0046658 anchored component of plasma membrane
cellular component GO:0009986 cell surface
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0005829 cytosol
cellular component GO:0005768 endosome
cellular component GO:0070062 extracellular exosome
cellular component GO:0031012 extracellular matrix
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005796 Golgi lumen
cellular component GO:0031226 intrinsic component of plasma membrane
cellular component GO:0043202 lysosomal lumen
cellular component GO:0045121 membrane raft
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1266738 Developmental Biology
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-1630316 Glycosaminoglycan metabolism
R-HSA-1630316 Glycosaminoglycan metabolism
R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism
R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism
R-HSA-1643685 Disease
R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928 HS-GAG biosynthesis
R-HSA-2022928 HS-GAG biosynthesis
R-HSA-2024096 HS-GAG degradation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2187338 Visual phototransduction
R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3656237 Defective EXT2 causes exostoses 2
R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-372790 Signaling by GPCR
R-HSA-376176 Signaling by ROBO receptors
R-HSA-3781865 Diseases of glycosylation
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-422475 Axon guidance
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-5668914 Diseases of metabolism
R-HSA-6806667 Metabolism of fat-soluble vitamins
R-HSA-71387 Metabolism of carbohydrates
R-HSA-71387 Metabolism of carbohydrates
R-HSA-9675108 Nervous system development
R-HSA-975634 Retinoid metabolism and transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002448 BXGD000115 Ameloblastoma Neoplasms
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0005411 BXGD000313 Biliary Atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0006012 BXGD000360 Borderline Personality Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006287 BXGD000390 Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0013264 BXGD000808 Muscular Dystrophy, Duchenne Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0016037 BXGD001035 Fibrodysplasia Ossificans Progressiva Musculoskeletal Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020635 BXGD001455 Hypopituitarism Nervous System Diseases; Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0025500 BXGD001874 Mesothelioma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0030286 BXGD002201 Pancreatic Diseases Digestive System Diseases
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0033774 BXGD002419 Pruritus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0149521 BXGD003328 Pancreatitis, Chronic Digestive System Diseases
C0151849 BXGD003486 Alkaline phosphatase raised Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0151872 BXGD003493 Prothrombin time increased Hemic and Lymphatic Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0155210 BXGD003780 Eyelid Xanthoma Nutritional and Metabolic Diseases; Eye Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0232720 BXGD004559 Pale feces (finding) Digestive System Diseases
C0232744 BXGD004561 Decreased liver function
C0235782 BXGD004769 Gallbladder Carcinoma Digestive System Diseases; Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0235991 BXGD004802 Small for gestational age (disorder) Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0267818 BXGD005781 Bile duct proliferation Digestive System Diseases
C0268307 BXGD005892 Conjugated hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0278480 BXGD006510 Stage III Colon Cancer Digestive System Diseases; Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280222 BXGD006723 stage, pancreatic cancer Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0302314 BXGD006837 Xanthoma Nutritional and Metabolic Diseases
C0302511 BXGD006849 Small for gestational age fetus Pathological Conditions, Signs and Symptoms
C0333463 BXGD006954 Senile Plaques Pathological Conditions, Signs and Symptoms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392514 BXGD008051 Hereditary hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0424503 BXGD008532 Dysmorphic facies
C0554103 BXGD009423 Intestinal malabsorption of fat Digestive System Diseases; Nutritional and Metabolic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0796154 BXGD010805 SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 1 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases; Mental Disorders; Behavior and Behavior Mechanisms; Cardiovascular Diseases
C0862312 BXGD011259 Epithelioid mesothelioma, malignant Neoplasms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1314665 BXGD012386 Serum alkaline phosphatase raised
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1511789 BXGD013183 Desmoplastic
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1848701 BXGD014967 Elevated hepatic transaminase
C1849766 BXGD015084 Periportal fibrosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C1855514 BXGD015505 Severe failure to thrive
C1859236 BXGD015867 Prolonged neonatal jaundice Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1861735 BXGD016071 Dementia, familial Danish Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases; Mental Disorders; Otorhinolaryngologic Diseases
C1867773 BXGD016471 CEREBRAL AMYLOID ANGIOPATHY, ITM2B-RELATED, 1
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2675627 BXGD017302 Acholic stool Digestive System Diseases
C2931404 BXGD018018 Albright's hereditary osteodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C3146254 BXGD018263 Stage III Colon Cancer AJCC v7
C3179455 BXGD018552 Niemann-Pick Disease, Type C1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C3277945 BXGD018726 Atretic gallbladder
C3494506 BXGD018968 Pseudohypoparathyroidism, Type Ia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C3714948 BXGD019440 PACHYONYCHIA CONGENITA 3
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4304293 BXGD022572 Dark yellow urine
C4317043 BXGD022718 Simpson-Golabi-Behmel syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases; Endocrine System Diseases
C4476869 BXGD022882 Elevated gamma-glutamyltransferase activity
C4520983 BXGD023052 Congenital atresia of extrahepatic bile duct Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C4525124 BXGD023120 Stage III Colon Cancer AJCC v8
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4726609 BXGD023846 Resectable Pancreatic Ductal Adenocarcinoma
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein