Showing entry for Glutamate dehydrogenase 2, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010709
Protein NameGlutamate dehydrogenase 2, mitochondrial
Uniport IdP49448
GeneGLUD2
Gene Id2747
DomainELFV_dehydrog; ELFV_dehydrog_N
Pfam PF00208   PF02812  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00220 Arginine biosynthesis
1. Metabolism 1.5 Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism
1. Metabolism 1.6 Metabolism of other amino acids hsa00471 D-Glutamine and D-glutamate metabolism
1. Metabolism 1.2 Energy metabolism hsa00910 Nitrogen metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
4. Cellular Processes 4.2 Cell growth and death hsa04217 Necroptosis
5. Organismal Systems 5.5 Excretory system hsa04964 Proximal tubule bicarbonate reclamation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006537 glutamate biosynthetic process
Biological Process GO:0006538 glutamate catabolic process
Biological Process GO:0006536 glutamate metabolic process
Biological Process GO:0055114 oxidation-reduction process
molecular function GO:0043531 ADP binding
molecular function GO:0004352 glutamate dehydrogenase (NAD+) activity
molecular function GO:0005525 GTP binding
molecular function GO:0070728 leucine binding
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
molecular function GO:0004353 glutamate dehydrogenase NAD(P)+ activity
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-8964539 Glutamate and glutamine metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0021345 BXGD001497 Infectious Mononucleosis Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085606 BXGD003201 Urgency of micturition Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234379 BXGD004662 Resting Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0240341 BXGD005032 Micrographia
C0240735 BXGD005052 Personality Change Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0241700 BXGD005108 Voice Fatigue Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0424448 BXGD008529 Mask-like facies Nervous System Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0557874 BXGD009444 Global developmental delay
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1504541 BXGD013151 Cerebellitis
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1843921 BXGD014620 Postural instability Nervous System Diseases
C1846865 BXGD014845 Substantia nigra gliosis Pathological Conditions, Signs and Symptoms
C1850496 BXGD015147 Neuronal loss in central nervous system
C1853237 BXGD015319 Isolated cases
C3160718 BXGD018468 PARKINSON DISEASE, LATE-ONSET
C3805715 BXGD019484 Short stepped shuffling gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4551584 BXGD023362 Brain atrophy Nervous System Diseases
C4553976 BXGD023554 Urinary Urgency, CTCAE 5
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0006162 L-Glutamic acid 147.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein