Showing entry for Ephrin type-A receptor 5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011074
Protein NameEphrin type-A receptor 5
Uniport IdP54756
GeneEPHA5
Gene Id2044
DomainEphA2_TM; Ephrin_lbd; fn3; Pkinase_Tyr; SAM_1
Pfam PF14575   PF01404   PF00041   PF07714   PF00536  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007411 axon guidance
Biological Process GO:0019933 cAMP-mediated signaling
Biological Process GO:0048013 ephrin receptor signaling pathway
Biological Process GO:0021766 hippocampus development
Biological Process GO:0007275 multicellular organism development
Biological Process GO:0048666 neuron development
Biological Process GO:0032793 positive regulation of CREB transcription factor activity
Biological Process GO:0033674 positive regulation of kinase activity
Biological Process GO:0032956 regulation of actin cytoskeleton organization
Biological Process GO:0043087 regulation of GTPase activity
Biological Process GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0005003 ephrin receptor activity
molecular function GO:0005004 GPI-linked ephrin receptor activity
molecular function GO:0005005 transmembrane-ephrin receptor activity
molecular function GO:0004714 transmembrane receptor protein tyrosine kinase activity
cellular component GO:0030424 axon
cellular component GO:0030425 dendrite
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0043005 neuron projection
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
cellular component GO:0005791 rough endoplasmic reticulum
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010308 BXGD000661 Congenital Hypothyroidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0010709 BXGD000689 Cyst Pathological Conditions, Signs and Symptoms; Neoplasms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0014740 BXGD000944 Erythema Chronicum Migrans Infections; Skin and Connective Tissue Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0017677 BXGD001147 Glossitis, Benign Migratory Stomatognathic Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0024198 BXGD001743 Lyme Disease Infections
C0027651 BXGD002009 Neoplasms Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0041834 BXGD002935 Erythema Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151313 BXGD003413 Sensory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0345958 BXGD007751 Large cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0346629 BXGD007831 Malignant neoplasm of large intestine Digestive System Diseases; Neoplasms
C0376154 BXGD007980 Skin callus Skin and Connective Tissue Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0751122 BXGD010325 Infantile Severe Myoclonic Epilepsy Nervous System Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1314691 BXGD012388 Age at menarche Behavior and Behavior Mechanisms
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1335177 BXGD012771 Ovarian Serous Adenocarcinoma Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1837315 BXGD014218 COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
C1839333 BXGD014369 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2 Nervous System Diseases
C1960398 BXGD016658 HER2-positive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2675481 BXGD017292 COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
C2677123 BXGD017364 COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
C3554460 BXGD019215 COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
C3873567 BXGD019863 Peripheral neuropathy due to and following chemotherapy Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0012352 Chelerythrine 348.12
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein