Showing entry for Serine/threonine-protein kinase N2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013632
Protein NameSerine/threonine-protein kinase N2
Uniport IdQ16513
GenePKN2
Gene Id5586
DomainHR1; Pkinase; Pkinase_C
Pfam PF02185   PF00069   PF00433  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05132 Salmonella infection
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05135 Yersinia infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0043297 apical junction assembly
Biological Process GO:0006915 apoptotic process
Biological Process GO:0007155 cell adhesion
Biological Process GO:0007049 cell cycle
Biological Process GO:0051301 cell division
Biological Process GO:0030030 cell projection organization
Biological Process GO:0010631 epithelial cell migration
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0032467 positive regulation of cytokinesis
Biological Process GO:0045931 positive regulation of mitotic cell cycle
Biological Process GO:0045070 positive regulation of viral genome replication
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:2000145 regulation of cell motility
Biological Process GO:0007165 signal transduction
Biological Process GO:0016032 viral process
molecular function GO:0005524 ATP binding
molecular function GO:0045296 cadherin binding
molecular function GO:0004698 calcium-dependent protein kinase C activity
molecular function GO:0017049 GTP-Rho binding
molecular function GO:0042826 histone deacetylase binding
molecular function GO:0016301 kinase activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0003723 RNA binding
molecular function GO:0070063 RNA polymerase binding
cellular component GO:0043296 apical junction complex
cellular component GO:0005813 centrosome
cellular component GO:0032154 cleavage furrow
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0045111 intermediate filament cytoskeleton
cellular component GO:0030027 lamellipodium
cellular component GO:0030496 midbody
cellular component GO:0016604 nuclear body
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-5625740 RHO GTPases activate PKNs
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005823 BXGD000339 Blood Pressure
C0005890 BXGD000345 Body Height
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007112 BXGD000429 Adenocarcinoma of prostate Neoplasms; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0040420 BXGD002861 Tonometry
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0871470 BXGD011316 Systolic Pressure
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1269955 BXGD012005 Tumor Cell Invasion
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000655 Harmalol 200.24
BXGC0001544 Harmaline 214.26
BXGC0001545 Harmine 212.25
BXGC0002588 Magnesium 24.31
BXGC0007014 Harman 182.22
BXGC0012352 Chelerythrine 348.12
BXGC0024554 D-luciferin 280
BXGC0034256 Rottlerin 516.18
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0051873 Sl-0101 516.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein