Showing entry for Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016436
Protein NameBifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Uniport IdQ6NYC1
GeneJMJD6
Gene Id23210
DomainJmjC
Pfam PF02373  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0048821 erythrocyte development
Biological Process GO:0007507 heart development
Biological Process GO:0070078 histone H3-R2 demethylation
Biological Process GO:0070079 histone H4-R3 demethylation
Biological Process GO:0001822 kidney development
Biological Process GO:0030324 lung development
Biological Process GO:0042116 macrophage activation
Biological Process GO:0006397 mRNA processing
Biological Process GO:0035513 oxidative RNA demethylation
Biological Process GO:0018395 peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006482 protein demethylation
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0043654 recognition of apoptotic cell
Biological Process GO:0048024 regulation of mRNA splicing, via spliceosome
Biological Process GO:0060041 retina development in camera-type eye
Biological Process GO:0008380 RNA splicing
Biological Process GO:0002040 sprouting angiogenesis
Biological Process GO:0033077 T cell differentiation in thymus
molecular function GO:0032451 demethylase activity
molecular function GO:0032452 histone demethylase activity
molecular function GO:0033746 histone demethylase activity (H3-R2 specific)
molecular function GO:0033749 histone demethylase activity (H4-R3 specific)
molecular function GO:0042802 identical protein binding
molecular function GO:0005506 iron ion binding
molecular function GO:0035515 oxidative RNA demethylase activity
molecular function GO:0070815 peptidyl-lysine 5-dioxygenase activity
molecular function GO:0106140 P-TEFb complex binding
molecular function GO:0003723 RNA binding
molecular function GO:0038023 signaling receptor activity
molecular function GO:0003727 single-stranded RNA binding
molecular function GO:0003713 transcription coactivator activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:1990904 ribonucleoprotein complex
Reactome
Pathway Id Pathway Name
R-HSA-3214842 HDMs demethylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006267 BXGD000383 Bronchiectasis Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011119 BXGD000698 Decompression Sickness Wounds and Injuries
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0016514 BXGD001066 Foot-and-Mouth Disease Infections; Animal Diseases
C0017574 BXGD001122 Gingivitis Infections; Stomatognathic Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019562 BXGD001336 Von Hippel-Lindau Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025500 BXGD001874 Mesothelioma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205734 BXGD004115 Diabetes, Autoimmune Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0220633 BXGD004303 Uveal melanoma Neoplasms; Eye Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0240066 BXGD005016 Iron deficiency Nutritional and Metabolic Diseases
C0265987 BXGD005598 Nevus comedonicus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0524909 BXGD009247 Hepatitis B, Chronic Digestive System Diseases; Infections
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0917805 BXGD011414 Transient Cerebral Ischemia Nervous System Diseases; Cardiovascular Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1512981 BXGD013196 Mammary Tumorigenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1610071 BXGD013448 Uhthoff's phenomenon
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C4733092 BXGD023907 estrogen receptor-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000247 L-Targinine 188.23
BXGC0000436 Glycerol 92.09
BXGC0002485 2-Oxopentanedioic acid 146.1
BXGC0003705 Chloride 35.45
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein