Showing entry for Vitamin D 25-hydroxylase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016585
Protein NameVitamin D 25-hydroxylase
Uniport IdQ6VVX0
GeneCYP2R1
Gene Id120227
Domainp450
Pfam PF00067  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00100 Steroid biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0036378 calcitriol biosynthetic process from calciol
Biological Process GO:0042738 exogenous drug catabolic process
Biological Process GO:0006082 organic acid metabolic process
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0010164 response to cesium ion
Biological Process GO:0010212 response to ionizing radiation
Biological Process GO:0042359 vitamin D metabolic process
Biological Process GO:0006766 vitamin metabolic process
Biological Process GO:0006805 xenobiotic metabolic process
molecular function GO:1902271 D3 vitamins binding
molecular function GO:0020037 heme binding
molecular function GO:0005506 iron ion binding
molecular function GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0008395 steroid hydroxylase activity
molecular function GO:0030343 vitamin D3 25-hydroxylase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1643685 Disease
R-HSA-196791 Vitamin D (calciferol) metabolism
R-HSA-211859 Biological oxidations
R-HSA-211897 Cytochrome P450 - arranged by substrate type
R-HSA-211916 Vitamins
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-556833 Metabolism of lipids
R-HSA-5579027 Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
R-HSA-5579029 Metabolic disorders of biological oxidation enzymes
R-HSA-5668914 Diseases of metabolism
R-HSA-8957322 Metabolism of steroids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005944 BXGD000355 Metabolic Bone Disorder Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008149 BXGD000520 Chlamydia Infections Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011351 BXGD000717 Dental Enamel Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014179 BXGD000905 Endometritis Female Urogenital Diseases and Pregnancy Complications
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020437 BXGD001381 Hypercalcemia Nutritional and Metabolic Diseases
C0020503 BXGD001411 Hyperparathyroidism, Secondary Endocrine System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024894 BXGD001810 Mastitis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026269 BXGD001897 Mitral Valve Stenosis Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027709 BXGD002026 Nephrocalcinosis Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028960 BXGD002101 Oligospermia Male Urogenital Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0035579 BXGD002560 Rickets Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0039621 BXGD002824 Tetany Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Nervous System Diseases
C0040128 BXGD002844 Thyroid Diseases Endocrine System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042170 BXGD002969 Uveomeningoencephalitic Syndrome Eye Diseases; Immune System Diseases; Nervous System Diseases
C0042870 BXGD003008 Vitamin D Deficiency Nutritional and Metabolic Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0085682 BXGD003238 Hypophosphatemia Nutritional and Metabolic Diseases
C0151332 BXGD003415 Active tuberculosis Infections
C0151721 BXGD003465 Testicular hypogonadism Endocrine System Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151825 BXGD003481 Bone pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0151849 BXGD003486 Alkaline phosphatase raised Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206682 BXGD004237 Follicular thyroid carcinoma Neoplasms
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0239174 BXGD004969 Late tooth eruption
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0241237 BXGD005088 Difficulty standing Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0264408 BXGD005387 Childhood asthma Respiratory Tract Diseases; Immune System Diseases
C0268689 BXGD006027 Vitamin D-dependent rickets, type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0410935 BXGD008453 Wide cranial sutures
C0456070 BXGD008863 Growth delay
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0523979 BXGD009227 Vitamin D3 measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0544755 BXGD009310 Genu varum Musculoskeletal Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0857973 BXGD011167 Elevated circulating parathyroid hormone level
C0919758 BXGD011440 Vitamin D measurement
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1291314 BXGD012209 Deficiency of monooxygenase
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1314665 BXGD012386 Serum alkaline phosphatase raised
C1337013 BXGD012876 Differentiated Thyroid Gland Carcinoma
C1384583 BXGD012942 Congenital absence of germinal epithelium of testes Male Urogenital Diseases
C1390474 BXGD012969 Increased susceptibility to fractures
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1833324 BXGD013912 Sparse bone trabeculae
C1833325 BXGD013913 Thin bony cortex
C1833329 BXGD013916 Bulging epiphyses
C1833667 BXGD013937 Elevated alkaline phosphatase of bone origin
C1837081 BXGD014193 Tibial bowing Musculoskeletal Diseases
C1837402 BXGD014228 Flat occiput
C1838657 BXGD014332 Vitamin D Hydroxylation-Deficient Rickets, Type 1B Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases
C1838659 BXGD014333 Deformed rib cage
C1838662 BXGD014334 Metaphyseal irregularity
C1838663 BXGD014335 Enlargement of the wrists
C1838664 BXGD014336 Enlargement of the ankles
C1847868 BXGD014893 Generalized aminoaciduria
C1848538 BXGD014938 Bulging of the costochondral junction
C1849300 BXGD015032 Widely patent fontanelles and sutures
C1854301 BXGD015391 Motor delay Mental Disorders
C1854928 BXGD015443 Protuberant abdomen
C1855841 BXGD015550 Hypocalcemic seizures Nutritional and Metabolic Diseases
C1857180 BXGD015682 Enlargement of the costochondral junction
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859461 BXGD015895 Femoral bowing Musculoskeletal Diseases
C1859778 BXGD015931 Postnatal growth retardation
C1861453 BXGD016049 Pseudohyperkalemia Cardiff Nutritional and Metabolic Diseases
C1865200 BXGD016298 Delayed epiphyseal ossification
C1866700 BXGD016416 Irregular, rachitic-like metaphyses
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1963077 BXGD016680 Bone Pain, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2919142 BXGD017867 Short Stature, CTCAE
C3805574 BXGD019481 Increased fracture rate
C3826457 BXGD019724 Diabetes in children
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C3887650 BXGD019911 Adult Rickets Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C4023065 BXGD021091 Low serum calcitriol
C4023801 BXGD021265 Fibular bowing Musculoskeletal Diseases
C4476534 BXGD022821 Subperiosteal bone resorption
C4529962 BXGD023178 Fatty Liver Disease
C4551565 BXGD023353 Rachitic rosary Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C4552810 BXGD023525 Irritability, CTCAE
C4554063 BXGD023559 Bone Pain, CTCAE 5.0
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722172 BXGD023791 Primary differentiated carcinoma of thyroid gland
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006372 Ergocalciferol 396.65
BXGC0008676 Haem 616.49
BXGC0049391 Betadex 1134.37
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein