adisease

Showing entry for Bone pain

General Disease Information
BXGD Id	BXGD003481
Disease Name	Bone pain
Disease CUI Id	C0151825
MeSH Codes	C23 C05
Disease Class Name	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
Semantic Type	Sign or Symptom
Human Phenotype Ontology Id	HP:0025142 HP:0000924
Human Phenotype Ontology Term	Constitutional symptom; Abnormality of the skeletal system
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O14788	BXGT004100	Tumor necrosis factor ligand superfamily member 11	8600	reviewed	Signaling
O15374	BXGT004157	Monocarboxylate transporter 5	9122	reviewed	Transporter
O15427	BXGT004167	Monocarboxylate transporter 4	9123	reviewed	Transporter
O43914	BXGT004635	TYRO protein tyrosine kinase-binding protein	7305	reviewed
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O75475	BXGT005130	PC4 and SFRS1-interacting protein	11168	reviewed	Signaling
O75874	BXGT005157	Isocitrate dehydrogenase [NADP] cytoplasmic	3417	reviewed
O94907	BXGT005340	Dickkopf-related protein 1	22943	reviewed
O94925	BXGT005342	Glutaminase kidney isoform, mitochondrial	2744	reviewed	Enzyme
P00749	BXGT005641	Urokinase-type plasminogen activator	5328	reviewed	Enzyme
P00918	BXGT005690	Carbonic anhydrase 2	760	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P04062	BXGT006140	Lysosomal acid glucosylceramidase	2629	reviewed
P05187	BXGT006339	Alkaline phosphatase, placental type	250	reviewed	Enzyme
P06748	BXGT006497	Nucleophosmin	4869	reviewed	Chaperone
P07288	BXGT006591	Prostate-specific antigen	354	reviewed	Enzyme
P08697	BXGT006815	Alpha-2-antiplasmin	5345	reviewed	Enzyme modulator
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10276	BXGT007553	Retinoic acid receptor alpha	5914	reviewed	Nuclear receptor
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P14784	BXGT008054	Interleukin-2 receptor subunit beta	3560	reviewed	Receptor
P15428	BXGT008121	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	3248	reviewed
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	1385	reviewed
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P21453	BXGT008654	Sphingosine 1-phosphate receptor 1	1901	reviewed	G-protein coupled receptor
P21549	BXGT008661	Serine--pyruvate aminotransferase	189	reviewed	Enzyme
P22413	BXGT008764	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	5167	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P25103	BXGT009020	Substance-P receptor	6869	reviewed	G-protein coupled receptor
P27352	BXGT009174	Cobalamin binding intrinsic factor	2694	reviewed
P31391	BXGT009535	Somatostatin receptor type 4	6754	reviewed	G-protein coupled receptor
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41146	BXGT010226	Nociceptin receptor	4987	reviewed	G-protein coupled receptor
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P43235	BXGT010368	Cathepsin K	1513	reviewed	Enzyme
P48735	BXGT010657	Isocitrate dehydrogenase [NADP], mitochondrial	3418	reviewed
P51692	BXGT010885	Signal transducer and activator of transcription 5B	6777	reviewed	Nucleic acid binding
P51795	BXGT010891	H(+)/Cl(-) exchange transporter 5	1184	reviewed	Ion channel
P55072	BXGT011103	Transitional endoplasmic reticulum ATPase	7415	reviewed
P56373	BXGT011164	P2X purinoceptor 3	5024	reviewed	Ion channel
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
Q02763	BXGT012667	Angiopoietin-1 receptor	7010	reviewed	Kinase
Q03431	BXGT012714	Parathyroid hormone/parathyroid hormone-related peptide receptor	5745	reviewed	G-protein coupled receptor
Q04721	BXGT012777	Neurogenic locus notch homolog protein 2	4853	reviewed
Q05516	BXGT012822	Zinc finger and BTB domain-containing protein 16	7704	reviewed	Transcription factor
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q14108	BXGT013440	Lysosome membrane protein 2	950	reviewed	Receptor
Q6N021	BXGT016378	Methylcytosine dioxygenase TET2	54790	reviewed
Q6VVX0	BXGT016585	Vitamin D 25-hydroxylase	120227	reviewed
Q7L266	BXGT016993	Isoaspartyl peptidase/L-asparaginase	80150	reviewed	Enzyme
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q8WTS6	BXGT018986	Histone-lysine N-methyltransferase SETD7	80854	reviewed	Epigenetic regulator
Q92796	BXGT019376	Disks large homolog 3	1741	reviewed
Q92945	BXGT019397	Far upstream element-binding protein 2	8570	reviewed	Enzyme
Q92959	BXGT019400	Solute carrier organic anion transporter family member 2A1	6578	reviewed	Transporter
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q99538	BXGT019931	Legumain	5641	reviewed	Enzyme
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q9H0A0	BXGT020434	RNA cytidine acetyltransferase	55226	reviewed
Q9Y286	BXGT022225	Sialic acid-binding Ig-like lectin 7	27036	reviewed	Receptor
Q9Y5X0	BXGT022305	Sorting nexin-10	29887	reviewed
O60936	BXGT022857	Nucleolar protein 3	8996	reviewed
Q99748	BXGT023217	Neurturin	4902	reviewed	Signaling
P35670	BXGT023695	Copper-transporting ATPase 2	540	reviewed	Transporter
P29590	BXGT024350	Protein PML	5371	reviewed
Q14980	BXGT025336	Nuclear mitotic apparatus protein 1	4926	reviewed
P51798	BXGT026083	H(+)/Cl(-) exchange transporter 7	1186	reviewed	Ion channel

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}