Showing entry for Mitogen-activated protein kinase kinase kinase 14


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019934
Protein NameMitogen-activated protein kinase kinase kinase 14
Uniport IdQ99558
GeneMAP3K14
Gene Id9020
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04064 NF-kappa B signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04210 Apoptosis
5. Organismal Systems 5.8 Development hsa04380 Osteoclast differentiation
5. Organismal Systems 5.1 Immune system hsa04625 C-type lectin receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04660 T cell receptor signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04668 TNF signaling pathway
5. Organismal Systems 5.1 Immune system hsa04672 Intestinal immune network for IgA production
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05120 Epithelial cell signaling in Helicobacter pylori infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05169 Epstein-Barr virus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0051607 defense response to virus
Biological Process GO:0007249 I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0006955 immune response
Biological Process GO:0038061 NIK/NF-kappaB signaling
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0033209 tumor necrosis factor-mediated signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0016301 kinase activity
molecular function GO:0004709 MAP kinase kinase kinase activity
molecular function GO:0004704 NF-kappaB-inducing kinase activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005829 cytosol
cellular component GO:0001650 fibrillar center
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389356 CD28 co-stimulation
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023343 BXGD001635 Leprosy Infections
C0023892 BXGD001715 Biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0024809 BXGD001808 Marijuana Abuse Chemically-Induced Disorders; Mental Disorders
C0025202 BXGD001832 melanoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038868 BXGD002781 Progressive supranuclear palsy Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0086981 BXGD003317 Sicca Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0200638 BXGD004043 Eosinophil count procedure
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236642 BXGD004815 Pick Disease of the Brain Nervous System Diseases; Mental Disorders
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242172 BXGD005138 Pelvic Inflammatory Disease Female Urogenital Diseases and Pregnancy Complications; Infections
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0334586 BXGD007126 Pleomorphic Xanthoastrocytoma Neoplasms
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0398686 BXGD008215 Primary immune deficiency disorder Immune System Diseases
C0400936 BXGD008264 Autoimmune liver disease Digestive System Diseases; Immune System Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0679395 BXGD009769 vascular ischemia Pathological Conditions, Signs and Symptoms
C0679427 BXGD009777 myeloblastosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1333064 BXGD012587 Classical Hodgkin's Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1335167 BXGD012768 Ovarian Mucinous Adenocarcinoma Neoplasms
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1608408 BXGD013434 Malignant transformation
C1969372 BXGD016775 Tubulointerstitial fibrosis
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347747 BXGD017040 Adult Classical Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2931480 BXGD018027 Neurofibromatosis, Type 3, mixed central and peripheral Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C3642347 BXGD019246 Basal-Like Breast Carcinoma
C3899645 BXGD020087 Childhood Pleomorphic Xanthoastrocytoma
C4289580 BXGD022491 Epithelioid glioblastoma
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0003487 Plumbagin 188.18
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein