Showing entry for Progressive supranuclear palsy


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD002781
Disease NameProgressive supranuclear palsy
Disease CUI IdC0038868
MeSH Codes C23   C11   C10  
Disease Class NamePathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
F7VJQ1 BXGT003310 Alternative prion protein 5621 reviewed
O14578 BXGT004072 Citron Rho-interacting kinase 11113 reviewed Kinase
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 4864 reviewed Transporter
O15146 BXGT004131 Muscle, skeletal receptor tyrosine-protein kinase 4593 reviewed Kinase
O15409 BXGT004166 Forkhead box protein P2 93986 reviewed
O60260 BXGT004864 E3 ubiquitin-protein ligase parkin 5071 reviewed Enzyme
O75116 BXGT005100 Rho-associated protein kinase 2 9475 reviewed Kinase
O75747 BXGT005149 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma 5288 reviewed Kinase
O95819 BXGT005398 Mitogen-activated protein kinase kinase kinase kinase 4 9448 reviewed Kinase
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P01034 BXGT005721 Cystatin-C 1471 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P04062 BXGT006140 Lysosomal acid glucosylceramidase 2629 reviewed
P04156 BXGT006156 Major prion protein 5621 reviewed
P04818 BXGT006269 Thymidylate synthase 7298 reviewed Enzyme
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P07101 BXGT006547 Tyrosine 3-monooxygenase 7054 reviewed
P07202 BXGT006565 Thyroid peroxidase 7173 reviewed Enzyme
P07225 BXGT006572 Vitamin K-dependent protein S 5627 reviewed
P07288 BXGT006591 Prostate-specific antigen 354 reviewed Enzyme
P08047 BXGT006720 Transcription factor Sp1 6667 reviewed Nucleic acid binding
P08133 BXGT006727 Annexin A6 309 reviewed
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C 5788 reviewed Enzyme
P09466 BXGT006892 Glycodelin 5047 reviewed Enzyme
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P0CG47 BXGT007467 Polyubiquitin-B 7314 reviewed Nucleic acid binding
P0DN79 BXGT007511 Cystathionine beta-synthase-like protein 875 reviewed
P10635 BXGT007595 Cytochrome P450 2D6 1565 reviewed
P10636 BXGT007596 Microtubule-associated protein tau 4137 reviewed
P10909 BXGT007630 Clusterin 1191 reviewed
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P18440 BXGT008404 Arylamine N-acetyltransferase 1 9 reviewed Enzyme
P18507 BXGT008411 Gamma-aminobutyric acid receptor subunit gamma-2 2566 reviewed Ion channel
P19440 BXGT008481 Glutathione hydrolase 1 proenzyme 2678 reviewed Enzyme
P21980 BXGT008715 Protein-glutamine gamma-glutamyltransferase 2 7052 reviewed Enzyme
P23378 BXGT008859 Glycine dehydrogenase (decarboxylating), mitochondrial 2731 reviewed Enzyme
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P25774 BXGT009066 Cathepsin S 1520 reviewed Enzyme
P27338 BXGT009172 Amine oxidase [flavin-containing] B 4129 reviewed
P29475 BXGT009353 Nitric oxide synthase, brain 4842 reviewed
P29536 BXGT009361 Leiomodin-1 25802 reviewed Cellular structure
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P34998 BXGT009781 Corticotropin-releasing factor receptor 1 1394 reviewed
P35520 BXGT009842 Cystathionine beta-synthase 875 reviewed
P35858 BXGT009876 Insulin-like growth factor-binding protein complex acid labile subunit 3483 reviewed Receptor
P36222 BXGT009914 Chitinase-3-like protein 1 1116 reviewed
P37840 BXGT010015 Alpha-synuclein 6622 reviewed Transporter
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P43354 BXGT010381 Nuclear receptor subfamily 4 group A member 2 4929 reviewed Nuclear receptor
P45985 BXGT010496 Dual specificity mitogen-activated protein kinase kinase 4 6416 reviewed Kinase
P46721 BXGT010536 Solute carrier organic anion transporter family member 1A2 6579 reviewed Transporter
P49768 BXGT010740 Presenilin-1 5663 reviewed Enzyme
P49810 BXGT010747 Presenilin-2 5664 reviewed Enzyme
P52758 BXGT010951 2-iminobutanoate/2-iminopropanoate deaminase 10247 reviewed
P55786 BXGT011125 Puromycin-sensitive aminopeptidase 9520 reviewed Enzyme
P60174 BXGT011294 Triosephosphate isomerase 7167 reviewed Enzyme
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60568 BXGT011315 Interleukin-2 3558 reviewed
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P62258 BXGT011415 14-3-3 protein epsilon 7531 reviewed Chaperone
P78330 BXGT011833 Phosphoserine phosphatase 5723 reviewed Enzyme
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 1020 reviewed Kinase
Q01959 BXGT012624 Sodium-dependent dopamine transporter 6531 reviewed Transporter
Q06787 BXGT012890 Synaptic functional regulator FMR1 2332 reviewed Nucleic acid binding
Q13148 BXGT013318 TAR DNA-binding protein 43 23435 reviewed
Q13464 BXGT013357 Rho-associated protein kinase 1 6093 reviewed Kinase
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 5300 reviewed
Q14203 BXGT013455 Dynactin subunit 1 1639 reviewed Chaperone
Q15118 BXGT013540 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 5163 reviewed Kinase
Q15257 BXGT013554 Serine/threonine-protein phosphatase 2A activator 5524 reviewed Enzyme modulator
Q15303 BXGT013557 Receptor tyrosine-protein kinase erbB-4 2066 reviewed Kinase
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q5S007 BXGT015650 Leucine-rich repeat serine/threonine-protein kinase 2 120892 reviewed Kinase
Q6N021 BXGT016378 Methylcytosine dioxygenase TET2 54790 reviewed
Q8N4C8 BXGT018510 Misshapen-like kinase 1 50488 reviewed Kinase
Q99558 BXGT019934 Mitogen-activated protein kinase kinase kinase 14 9020 reviewed Kinase
Q99700 BXGT019949 Ataxin-2 6311 reviewed Nucleic acid binding
Q9NZJ5 BXGT021275 Eukaryotic translation initiation factor 2-alpha kinase 3 9451 reviewed Kinase
Q9UHD2 BXGT021697 Serine/threonine-protein kinase TBK1 29110 reviewed Kinase
Q9UIC8 BXGT021716 Leucine carboxyl methyltransferase 1 51451 reviewed
Q9Y617 BXGT022314 Phosphoserine aminotransferase 29968 reviewed
Q9Y6W6 BXGT022342 Dual specificity protein phosphatase 10 11221 reviewed
O60502 BXGT023392 Protein O-GlcNAcase 10724 reviewed
A6NGN9 BXGT023893 IgLON family member 5 402665 reviewed
Q15286 BXGT024296 Ras-related protein Rab-35 11021 reviewed
Q12888 BXGT024878 TP53-binding protein 1 7158 reviewed Epigenetic regulator
P61916 BXGT025881 NPC intracellular cholesterol transporter 2 10577 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease