Showing entry for Prohibitin-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019941
Protein NameProhibitin-2
Uniport IdQ99623
GenePHB2
Gene Id11331
DomainBand_7
Pfam PF01145  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007202 activation of phospholipase C activity
Biological Process GO:1990051 activation of protein kinase C activity
Biological Process GO:0140374 antiviral innate immune response
Biological Process GO:0042113 B cell activation
Biological Process GO:0023035 CD40 signaling pathway
Biological Process GO:0016477 cell migration
Biological Process GO:0071456 cellular response to hypoxia
Biological Process GO:0071300 cellular response to retinoic acid
Biological Process GO:0002377 immunoglobulin production
Biological Process GO:0039520 induction by virus of host autophagy
Biological Process GO:0060749 mammary gland alveolus development
Biological Process GO:0060744 mammary gland branching involved in thelarche
Biological Process GO:0006851 mitochondrial calcium ion transmembrane transport
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:0000423 mitophagy
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0043433 negative regulation of DNA-binding transcription factor activity
Biological Process GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
Biological Process GO:0033600 negative regulation of mammary gland epithelial cell proliferation
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:1902808 positive regulation of cell cycle G1/S phase transition
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0031536 positive regulation of exit from mitosis
Biological Process GO:1901224 positive regulation of NIK/NF-kappaB signaling
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0050821 protein stabilization
Biological Process GO:0060762 regulation of branching involved in mammary gland duct morphogenesis
Biological Process GO:1900208 regulation of cardiolipin metabolic process
Biological Process GO:1904959 regulation of cytochrome-c oxidase activity
Biological Process GO:0009611 response to wounding
Biological Process GO:0039529 RIG-I signaling pathway
Biological Process GO:0007062 sister chromatid cohesion
molecular function GO:0033218 amide binding
molecular function GO:0030331 estrogen receptor binding
molecular function GO:0042802 identical protein binding
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0047485 protein N-terminus binding
molecular function GO:0046625 sphingolipid binding
cellular component GO:0030424 axon
cellular component GO:0071944 cell periphery
cellular component GO:0009986 cell surface
cellular component GO:0005737 cytoplasm
cellular component GO:0098982 GABA-ergic synapse
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005741 mitochondrial outer membrane
cellular component GO:0035632 mitochondrial prohibitin complex
cellular component GO:0005739 mitochondrion
cellular component GO:0016363 nuclear matrix
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0048786 presynaptic active zone
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-382551 Transport of small molecules
R-HSA-8949215 Mitochondrial calcium ion transport
R-HSA-8949664 Processing of SMDT1
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004610 BXGD000281 Bacteremia Pathological Conditions, Signs and Symptoms; Infections
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007140 BXGD000447 Carcinosarcoma Neoplasms
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014740 BXGD000944 Erythema Chronicum Migrans Infections; Skin and Connective Tissue Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017677 BXGD001147 Glossitis, Benign Migratory Stomatognathic Diseases
C0018203 BXGD001184 Chronic granulomatous disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022680 BXGD001576 Polycystic Kidney Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024198 BXGD001743 Lyme Disease Infections
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024814 BXGD001809 Marinesco-Sjogren syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0024894 BXGD001810 Mastitis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0029423 BXGD002143 Cartilaginous exostosis Neoplasms; Musculoskeletal Diseases
C0034013 BXGD002450 Precocious Puberty Endocrine System Diseases
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0036323 BXGD002595 Schistosomiasis Infections
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0039128 BXGD002794 Syphilis Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0040558 BXGD002873 Toxoplasmosis Infections
C0041296 BXGD002903 Tuberculosis Infections
C0041330 BXGD002917 Tuberculosis, Spinal Infections; Musculoskeletal Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079774 BXGD003101 Peripheral T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0220620 BXGD004299 Gastrointestinal Carcinoid Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0220633 BXGD004303 Uveal melanoma Neoplasms; Eye Diseases
C0235592 BXGD004758 Cervical lymphadenopathy Hemic and Lymphatic Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238462 BXGD004937 Medullary carcinoma of thyroid Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242381 BXGD005159 Lyme Arthritis Infections
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0338508 BXGD007196 Optic Atrophy 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376154 BXGD007980 Skin callus Skin and Connective Tissue Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0520463 BXGD009085 Chronic active hepatitis Digestive System Diseases
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0751072 BXGD010312 Frontotemporal Lobar Degeneration Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0751265 BXGD010370 Learning Disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0795825 BXGD010741 Chromosome 8, trisomy 8p Pathological Conditions, Signs and Symptoms
C0850705 BXGD010906 Adult Acquired Toxoplasmosis Infections
C0856169 BXGD011096 Endothelial dysfunction
C0877445 BXGD011350 Candidemia Pathological Conditions, Signs and Symptoms; Infections
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1112709 BXGD011682 non-gonococcal urethritis (NGU) Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1281901 BXGD012133 Fatty acid measurement
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1411966 BXGD013047 Clostridium; difficile (disorder)
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1567435 BXGD013413 Polycystic Kidney - body part Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1704321 BXGD013544 Nephrotic Syndrome, Minimal Change Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1841984 BXGD014487 GLOMUVENOUS MALFORMATIONS Neoplasms
C1862389 BXGD016126 ATRIAL SEPTAL DEFECT 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C2986665 BXGD018237 Early-Stage Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C3532942 BXGD019060 Mixed dementia Nervous System Diseases; Mental Disorders; Cardiovascular Diseases
C4020732 BXGD020474 Mitochondrial abnormalities
C4552213 BXGD023495 Broad autism phenotype
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4733092 BXGD023907 estrogen receptor-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0027063 Rocaglamide 505.21
BXGC0034035 Capsaicin 305.2
BXGC0047069 Didesmethylrocaglamide 477.18
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein