Showing entry for MAP kinase-interacting serine/threonine-protein kinase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020521
Protein NameMAP kinase-interacting serine/threonine-protein kinase 2
Uniport IdQ9HBH9
GeneMKNK2
Gene Id2872
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04066 HIF-1 signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0071243 cellular response to arsenic-containing substance
Biological Process GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Biological Process GO:0030097 hemopoiesis
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0006417 regulation of translation
molecular function GO:0005524 ATP binding
molecular function GO:0009931 calcium-dependent protein serine/threonine kinase activity
molecular function GO:0005516 calmodulin binding
molecular function GO:0046872 metal ion binding
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0016604 nuclear body
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0016605 PML body
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0008924 BXGD000574 Cleft upper lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0868908 BXGD011302 Pancolitis Digestive System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000655 Harmalol 200.24
BXGC0001544 Harmaline 214.26
BXGC0001545 Harmine 212.25
BXGC0003705 Chloride 35.45
BXGC0007014 Harman 182.22
BXGC0012352 Chelerythrine 348.12
BXGC0024554 D-luciferin 280
BXGC0034256 Rottlerin 516.18
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0051873 Sl-0101 516.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein