Showing entry for 3-Hydroxyflavone


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0004378
Compound Name3-Hydroxyflavone
Structure
FormulaC15H10O3
InchiKeyHVQAJTFOCKOKIN-UHFFFAOYSA-N
SMILESOC1=C(OC2=CC=CC=C2C1=O)C1=CC=CC=C1
InchiInChI=1S/C15H10O3/c16-13-11-8-4-5-9-12(11)18-15(14(13)17)10-6-2-1-3-7-10/h1-9,17H
IUPAC3-hydroxy-2-phenyl-4H-chromen-4-one
Molecular Weight238.24
Pubchem Id11349
Chembl IdCHEMBL294009
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50187668
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT019667 Aurora kinase B reviewed Kinase AURKB - 4290 - -
reviewed BXGT021247 Dipeptidyl peptidase 3 reviewed Enzyme DPP3 - 188200 - -
reviewed BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B - >100000 - -
reviewed BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 - >100000 - -
reviewed BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 - 73000 - -
reviewed BXGT007552 Androgen receptor reviewed Nuclear receptor AR - 23500 - -
reviewed BXGT007329 DNA gyrase subunit A reviewed gyrA - >2090000 - -
reviewed BXGT007520 Calmodulin-1 reviewed CALM1 - 55200 - -
reviewed BXGT024595 Calmodulin-3 reviewed CALM3 - 55200 - -
reviewed BXGT007521 Calmodulin-2 reviewed CALM2 - 55200 - -
reviewed BXGT010694 Fatty acid synthase reviewed Enzyme FASN - >100000 - -
reviewed BXGT010602 Xanthine dehydrogenase/oxidase reviewed Enzyme XDH - >100000 - -
reviewed BXGT005689 Carbonic anhydrase 1 reviewed CA1 5210 - - -
reviewed BXGT005689 Carbonic anhydrase 1 reviewed CA1 5100 - - -
reviewed BXGT005690 Carbonic anhydrase 2 reviewed CA2 9300 - - -
reviewed BXGT005690 Carbonic anhydrase 2 reviewed CA2 9200 - - -
reviewed BXGT013670 Carbonic anhydrase 9 reviewed CA9 5540 - - -
reviewed BXGT013670 Carbonic anhydrase 9 reviewed CA9 5630 - - -
reviewed BXGT004601 Carbonic anhydrase 12 reviewed CA12 6590 - - -
reviewed BXGT004601 Carbonic anhydrase 12 reviewed CA12 6650 - - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - - 10000 -
CHEMBL CHEMBL294009
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 3981 nM
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 Inhibition - - -
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B IC50 '>' 100000 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 25118 nM
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A Activity - - -
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 12589 nM
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 25118 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 25118 nM
Q8IL88 BXGT018311 HSP40, subfamily A, putative unreviewed - PF3D7_1437900 AbsAC1000_uM '=' 5 uM
O60218 BXGT004858 Aldo-keto reductase family 1 member B10 reviewed Enzyme AKR1B10 Inhibition - - -
P35503 BXGT009840 UDP-glucuronosyltransferase 1-3 reviewed - UGT1A3 Activity '=' 604 pm/min/mg
P49327 BXGT010694 Fatty acid synthase reviewed Enzyme FASN IC50 '>' 100000 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 370 pm/min/mg
P0DTE4 BXGT022286 UDP-glucuronosyltransferase 2A1 reviewed - UGT2A1 Activity '=' 320 pm/min/mg
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Activity - - -
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 114 pm/min/mg
P19224 BXGT008468 UDP-glucuronosyltransferase 1-6 reviewed - UGT1A6 Activity '=' 0 pm/min/mg
Q9HAW7 BXGT020508 UDP-glucuronosyltransferase 1-7 reviewed - UGT1A7 Activity '=' 57 pm/min/mg
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 25118 nM
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Activity '=' 30 pm/min/mg
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 39810 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 133 %
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Activity '=' 531 pm/min/mg
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Activity '=' 600 pm/min/mg
P0DTE4 BXGT022286 UDP-glucuronosyltransferase 2A1 reviewed - UGT2A1 Activity '=' 163 pm/min/mg
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Activity - - -
Q965D6 BXGT019601 3-oxoacyl-acyl-carrier protein reductase unreviewed - fabG Activity - - -
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 31622 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 28183 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 IC50 '=' 73000 nM
P0DP23 BXGT007520 Calmodulin-1 reviewed - CALM1 IC50 '=' 55200 nM
Q965D5 BXGT019600 Enoyl-acyl-carrier protein reductase unreviewed - fabI Activity - - -
P15304 BXGT008104 Hormone-sensitive lipase reviewed - Lipe Inhibition '=' 23 %
P47989 BXGT010602 Xanthine dehydrogenase/oxidase reviewed Enzyme XDH IC50 '>' 100000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 9200 nM
Q965D7 BXGT019602 Beta-hydroxyacyl-ACP dehydratase unreviewed - fabZ Activity - - -
P0AES4 BXGT007329 DNA gyrase subunit A reviewed - gyrA IC50 '>' 500 ug.mL-1
P0AES6 BXGT007331 DNA gyrase subunit B reviewed - gyrB IC50 '>' 500 ug.mL-1
P49327 BXGT010694 Fatty acid synthase reviewed Enzyme FASN Inhibition '=' 6 %
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 25118 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 IC50 '>' 100000 nM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Ki '=' 5100 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki '=' 9300 nM
Q16790 BXGT013670 Carbonic anhydrase 9 reviewed - CA9 Ki '=' 5630 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 7079 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR IC50 '=' 23500 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 10000 nM
P0DP23 BXGT007520 Calmodulin-1 reviewed - CALM1 Ratio IC50 '=' 0 -
P22310 BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed - UGT1A4 Activity '=' 0 pm/min/mg
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 32642 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki '=' 9200 nM
P16116 BXGT008197 Aldo-keto reductase family 1 member B1 reviewed - AKR1B1 Inhibition '=' 0 %
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 79432 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR EC150 - - -
P54855 BXGT011088 UDP-glucuronosyltransferase 2B15 reviewed - UGT2B15 Activity '=' 64 pm/min/mg
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 39810 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 39810 nM
Q02880 BXGT012677 DNA topoisomerase 2-beta reviewed - TOP2B CC50 - - -
Q16790 BXGT013670 Carbonic anhydrase 9 reviewed - CA9 Ki '=' 5540 nM
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Activity '=' 35 pm/min/mg
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 50 pm/min/mg
O43570 BXGT004601 Carbonic anhydrase 12 reviewed - CA12 Ki '=' 6650 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 7943 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 7943 nM
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 35481 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 35481 nM
P62826 BXGT011463 GTP-binding nuclear protein Ran reviewed Enzyme modulator RAN Potency - 35481 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 89125 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 730 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 3 nM
O43570 BXGT004601 Carbonic anhydrase 12 reviewed - CA12 Ki '=' 6590 nM
P0DP23 BXGT007520 Calmodulin-1 reviewed - CALM1 Inhibition - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 EC150 - - -
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 15848 nM
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 7943 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Kd '=' 10000 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 15848 nM
Q16678 BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 IC50 '=' 90 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 18356 nM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Ki '=' 5210 nM
P03126 BXGT006024 Protein E6 reviewed - E6 Inhibition - - -
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 102 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00038 Tea Camellia sinensis Teas
BXGF00041 Papaya Carica papaya Fruits
BXGF00049 Chicory Cichorium intybus Vegetables
BXGF00151 Pomegranate Punica granatum Fruits
BXGF00162 Red raspberry Rubus idaeus Fruits
BXGF00186 Fenugreek Trigonella foenum-graecum Herbs and Spices
BXGF00337 Ginkgo nuts Ginkgo biloba Herbs and Spices
BXGF00809 Brassicas Vegetables
BXGF01147 Chelidonium majus Chelidonium majus Medicinal Plant
BXGF02377 Cichorium glandulosum Cichorium glandulosum Others
BXGF04909 Hippophae fructus Hippophae fructus Others
BXGF04964 Chrysanthemum morifolium Chrysanthemum morifolium Medicinal Plant
BXGF05819 Citrus aurantium Citrus aurantium Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease