Showing entry for Histamine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0013854
Compound NameHistamine
Structure
FormulaC5H9N3
InchiKeyNTYJJOPFIAHURM-UHFFFAOYSA-N
SMILESNCCc1cnc[nH]1
InchiInChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
IUPAC2-(1H-imidazol-5-yl)ethanamine
Molecular Weight111.08
Pubchem Id774
Chembl IdCHEMBL90
Targets of Information Source
DrugBank DB05381
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 approved; investigational agonist
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 approved; investigational agonist
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 approved; investigational agonist
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 approved; investigational agonist
Q05940 BXGT012846 Synaptic vesicular amine transporter reviewed Transporter SLC18A2 approved; investigational -
PDB HSM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P00918 BXGT005690 Carbonic anhydrase 2 reviewed CA2 - - - 125000 -
Q94734 BXGT019555 Nitrophorin-4 reviewed - - - - -
P50135 BXGT010776 Histamine N-methyltransferase reviewed HNMT - - - - -
P06988 BXGT006531 Histidinol dehydrogenase reviewed hisD - - - - -
Q26239 BXGT013913 Nitrophorin-1 reviewed - - - - -
O77421 BXGT005192 Female-specific histamine-binding protein 2 reviewed - - - 1.7 -
O77421 BXGT005192 Female-specific histamine-binding protein 2 reviewed - - - - -
Q9BIH3 BXGT020097 D7-related 4 protein unreviewed d7r4 - - - - -
Q5GQ85 BXGT015388 Allergen Arg r 1 reviewed - - - - -
Q09JX9 BXGT013046 Monomine unreviewed - - - 7.1 -
P00760 BXGT005644 Cationic trypsin reviewed - - - - -
Q6PQK2 BXGT016482 Nitrophorin-7 reviewed - - - - -
A4GK78 BXGT023911 Ebony unreviewed e - - - 638900 -
Q9I0I4 BXGT020688 Probable chemotaxis transducer unreviewed PA2654 - - - 639 -
Binding DB 7966
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT013665 Glutaminyl-peptide cyclotransferase reviewed Enzyme QPCT 850000 - - -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 16 - - -
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 10 - - -
reviewed BXGT009534 Histamine H1 receptor reviewed Hrh1 >10000 - - -
reviewed BXGT009533 Histamine H1 receptor reviewed HRH1 100 - - -
reviewed BXGT010583 Histamine H2 receptor reviewed HRH2 100 - - -
reviewed BXGT020813 Histamine H3 receptor reviewed HRH3 100 - - -
reviewed BXGT010583 Histamine H2 receptor reviewed HRH2 >10000 - - -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 >10000 - - -
reviewed BXGT008440 D(1A) dopamine receptor reviewed Drd1 >10000 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 >10000 - - -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 1258.92 - - -
reviewed BXGT009533 Histamine H1 receptor reviewed HRH1 3162.27 - - -
reviewed BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 >10000 - - -
reviewed BXGT009621 5-hydroxytryptamine receptor 7 reviewed Htr7 1000 - - -
reviewed BXGT009621 5-hydroxytryptamine receptor 7 reviewed Htr7 >10000 - - -
reviewed BXGT009019 Histamine H2 receptor reviewed Hrh2 17 - - -
reviewed BXGT014808 Nischarin reviewed Nisch >10000 - - -
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 >10000 - - -
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 15.2 - - -
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 5.4 - - -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 8.1 - - -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 3442.3 - - -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 17 - - -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 2.5 - - -
reviewed BXGT019728 Trace amine-associated receptor 1 reviewed G-protein coupled receptor TAAR1 3107 - - -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 1258.93 - - -
reviewed BXGT009533 Histamine H1 receptor reviewed HRH1 >10000 - - -
reviewed BXGT009533 Histamine H1 receptor reviewed HRH1 9900 - - -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 2060 - - -
reviewed BXGT009533 Histamine H1 receptor reviewed HRH1 4650 - - -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 7010 - - -
reviewed BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 >10000 - - -
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 2.32 - - -
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 2.61 - - -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 39.8 - - -
reviewed BXGT009533 Histamine H1 receptor reviewed HRH1 4600 - - -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 190 - - -
reviewed BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 1200 - - -
reviewed BXGT010583 Histamine H2 receptor reviewed HRH2 1200 - - -
reviewed BXGT009533 Histamine H1 receptor reviewed HRH1 - - 0.851 -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 - - - 12
reviewed BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 - - - 1202
reviewed BXGT010583 Histamine H2 receptor reviewed HRH2 - - - 1000
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 - - - 191
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 - - - 25
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 - - - 640
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 - - - 77
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 - - - 75
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 - - - 13
reviewed BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 - - - 463
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 - - - 1800
reviewed BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 - - - 650
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 - - - 88
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 - - - 45
reviewed BXGT019330 Histamine H4 receptor reviewed Hrh4 42 - - -
reviewed BXGT019329 Histamine H4 receptor reviewed Hrh4 136 - - -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 4.8 - - -
reviewed BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 5000 - - -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 6000 - - -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 8 - - -
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 16 - - -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 - - - 7.9
reviewed BXGT021392 Histamine H3 receptor reviewed Hrh3 - - - 62
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 - - - 11
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 - - - 13
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 - - - 190
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 - - - 13
reviewed BXGT019330 Histamine H4 receptor reviewed Hrh4 - - - 94
reviewed BXGT011236 Histamine H3 receptor reviewed Hrh3 68 - - -
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 13 - - -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 1.6 - - -
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 5.2 - - -
reviewed BXGT020813 Histamine H3 receptor reviewed HRH3 10 - - -
reviewed BXGT020813 Histamine H3 receptor reviewed HRH3 0.144544 - - -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 60 - - -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 9 - - -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 13.4 - - -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 - - - 190
reviewed BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 - - - 1200
reviewed BXGT010583 Histamine H2 receptor reviewed HRH2 - - - 1200
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 - - - 25.1
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 - - - 11.6
reviewed BXGT010583 Histamine H2 receptor reviewed HRH2 - - - 1202.26
reviewed BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 - - - 1258.93
reviewed BXGT009533 Histamine H1 receptor reviewed HRH1 - - 0.776 -
reviewed BXGT009533 Histamine H1 receptor reviewed HRH1 - - 1 -
reviewed BXGT009533 Histamine H1 receptor reviewed HRH1 - - 10 -
reviewed BXGT009534 Histamine H1 receptor reviewed Hrh1 - - 10 -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 12.02 - - -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 - - - 190.55
reviewed BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 - - - 1202.26
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 - - - 25.12
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 - - - 12.02
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 - - - 12.88
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 - - - 9.12
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 79432.82 - - -
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 11.75 - - -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 - - - 25.12
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 - - - 15.85
reviewed BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 6.31 - - -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 15.85 - - -
reviewed BXGT016060 Solute carrier family 22 member 1 reviewed Slc22a1 141000 - - -
reviewed BXGT021408 Solute carrier family 22 member 2 reviewed Slc22a2 171000 - - -
reviewed BXGT016060 Solute carrier family 22 member 1 reviewed Slc22a1 1400000 - - -
reviewed BXGT021408 Solute carrier family 22 member 2 reviewed Slc22a2 390000 - - -
reviewed BXGT005150 Solute carrier family 22 member 3 reviewed Transporter SLC22A3 140000 - - -
reviewed BXGT009019 Histamine H2 receptor reviewed Hrh2 - - 117490 -
reviewed BXGT010583 Histamine H2 receptor reviewed HRH2 - - 69183 -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 - 158 - -
CHEMBL CHEMBL90
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 EC50 '=' 15 nM
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 pKb '=' 9 -
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Activity '=' 1 -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 EC50 '=' 13 nM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 KA '=' 2 uM
Q9D6N1 BXGT020260 Carbonic anhydrase 13 reviewed - Ca13 KA '=' 4 uM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki '=' 1000000 nM
O15244 BXGT004140 Solute carrier family 22 member 2 reviewed Transporter SLC22A2 Km '=' 1300000 nM
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 EC50 '=' 463 nM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 EC50 '=' 77 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Alpha '=' 1 -
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 31622 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 EC50 '=' 45 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 20 nM
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Kd '=' 0 nM
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Kd '=' 1 nM
Q9QYN8 BXGT021392 Histamine H3 receptor reviewed - Hrh3 Agonistic activity - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Emax '=' 1 %
P07451 BXGT006627 Carbonic anhydrase 3 reviewed - CA3 KA '=' 36 uM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 KA '=' 125 uM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 Ki '=' 12 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Activity - - -
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 Inhibition '=' 4 %
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 KA '=' 2 uM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 Emax '=' 1 %
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 Emax '=' 1 %
Q99N23 BXGT019994 Carbonic anhydrase 15 reviewed - Ca15 KA '=' 18 uM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 Ki '=' 19 nM
Q9Z0E8 BXGT022397 Solute carrier family 22 member 5 reviewed - Slc22a5 Activity - - -
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '>' 1000000 nM
P97292 BXGT012202 Histamine H2 receptor reviewed - Hrh2 Relative potency '=' 1 -
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 Relative potency '=' 1 -
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Intrinsic activity '=' 1 -
Q9QYN8 BXGT021392 Histamine H3 receptor reviewed - Hrh3 pD2 '=' 7 -
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Emax '=' 100 %
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Intrinsic activity '=' 1 -
P54803 BXGT011082 Galactocerebrosidase reviewed - GALC Potency - 707 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 10000 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 Activity - - -
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 EC50 '=' 25 nM
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki '=' 50118 nM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 EC50 '=' 25 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 EC50 '=' 190 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 EC50 '=' 190 nM
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 Activity '=' 3007 uM
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 pD2 '=' 5 -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ratio '=' 1 -
P43166 BXGT010364 Carbonic anhydrase 7 reviewed - CA7 KA '=' 37 uM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 Activity '=' 110 %
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki '=' 31622 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 Ki '=' 7 nM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 Ki '=' 10 nM
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 Kd '=' 69183 nM
Q91ZY1 BXGT019329 Histamine H4 receptor reviewed - Hrh4 EC50 '=' 158 nM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 Intrinsic activity '=' 1 -
Q16790 BXGT013670 Carbonic anhydrase 9 reviewed - CA9 KA '=' 35 uM
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Ki '=' 7 nM
Q9JI35 BXGT020813 Histamine H3 receptor reviewed - HRH3 pD2 '=' 7 -
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Kd '=' 10 nM
Q95323 BXGT019579 Carbonic anhydrase 4 reviewed - CA4 KA '=' 41 uM
P22748 BXGT008802 Carbonic anhydrase 4 reviewed - CA4 Kcat '=' 3 10^6/s
P43166 BXGT010364 Carbonic anhydrase 7 reviewed - CA7 Kcat '=' 15 10^5/s
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 Activity '=' 100 -
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Activity '=' 100 -
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Relative potency '=' 100 %
Q8VH26 BXGT018927 Muscarinic acetylcholine receptor unreviewed - GPM3 pA2 - - -
O43570 BXGT004601 Carbonic anhydrase 12 reviewed - CA12 KA '=' 27 uM
Q9QYN8 BXGT021392 Histamine H3 receptor reviewed - Hrh3 pD2 '=' 7 -
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 pD2 '=' 6 -
P22748 BXGT008802 Carbonic anhydrase 4 reviewed - CA4 Ka '=' 25 uM
P00811 BXGT005666 Beta-lactamase reviewed - ampC Potency '=' 3162277 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki '=' 39810 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Change '=' 284 %
P53615 BXGT011003 Carbonic anhydrase reviewed - NCE103 Kcat '=' 19 10'5/s
P53615 BXGT011003 Carbonic anhydrase reviewed - NCE103 Ka '=' 20 uM
Q3I4V7 BXGT014421 Carbonic anhydrase unreviewed - CAN2 Kcat '=' 6 10'5/s
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 79 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 Intrinsic activity '=' 1 -
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 Ki '=' 11 nM
Q9JI35 BXGT020813 Histamine H3 receptor reviewed - HRH3 pD2 '=' 6 -
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 EC50 '=' 1000 nM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 EC50 '=' 12 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki '=' 79432 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki '=' 19952 nM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 Ki '=' 9 nM
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 pD2 '=' 5 -
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 1800 nM
Q63089 BXGT016060 Solute carrier family 22 member 1 reviewed - Slc22a1 Km '=' 98600 nM
Q3I4V7 BXGT014421 Carbonic anhydrase unreviewed - CAN2 KA '=' 33 uM
Q3I4V7 BXGT014421 Carbonic anhydrase unreviewed - CAN2 Kcat '=' 3 10'5/s
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 pD2 '=' 6 -
P35218 BXGT009796 Carbonic anhydrase 5A, mitochondrial reviewed - CA5A Ka '=' 2 uM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 23778 nM
Q91ZY2 BXGT019330 Histamine H4 receptor reviewed - Hrh4 Ki '=' 79 nM
Q91ZY1 BXGT019329 Histamine H4 receptor reviewed - Hrh4 Ki '=' 63 nM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Activity '=' 165 %
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Activity '=' 100 %
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 75 nM
P22748 BXGT008802 Carbonic anhydrase 4 reviewed - CA4 KA '=' 37 uM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 54 nM
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 pD2 '=' 5 -
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 Ki '=' 9 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
P97292 BXGT012202 Histamine H2 receptor reviewed - Hrh2 Effect '=' - -
P70174 BXGT011660 Histamine H1 receptor reviewed - Hrh1 Effect '=' - -
Q91ZY2 BXGT019330 Histamine H4 receptor reviewed - Hrh4 Intrinsic activity '=' 1 -
Q91ZY1 BXGT019329 Histamine H4 receptor reviewed - Hrh4 Intrinsic activity '=' 1 -
P23280 BXGT008844 Carbonic anhydrase 6 reviewed - CA6 KA '=' 6 uM
P58406 BXGT011236 Histamine H3 receptor reviewed - Hrh3 Ki '=' 68 nM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Ka '=' 0 uM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 EC50 '=' 199 nM
Q91ZY2 BXGT019330 Histamine H4 receptor reviewed - Hrh4 EC50 '=' 5011 nM
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 EC50 '=' 1200 nM
P53615 BXGT011003 Carbonic anhydrase reviewed - NCE103 Km '=' 9500000 nM
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Kd '=' 0 nM
Q9JI35 BXGT020813 Histamine H3 receptor reviewed - HRH3 p[A]50 '=' 7 -
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 Ki '=' 33 nM
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 EC50 '=' 1202 nM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 EC50 '=' 9 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 Ki '=' 14 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Kcat '=' 2 10'6/s
Q50565 BXGT014936 Carbonic anhydrase unreviewed - MTH_1582 Km '=' 1700000 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ka '=' 74 uM
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Emax '=' 1 %
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 Emax '=' 1 %
Q9QYN8 BXGT021392 Histamine H3 receptor reviewed - Hrh3 Intrinsic activity '=' 1 -
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 15848 nM
Q63089 BXGT016060 Solute carrier family 22 member 1 reviewed - Slc22a1 Ki '=' 1400000 nM
Q7RTT9 BXGT017086 Equilibrative nucleoside transporter 4 reviewed Transporter SLC29A4 Activity - - -
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 Ki '=' 6 nM
Q9Y2D0 BXGT022229 Carbonic anhydrase 5B, mitochondrial reviewed - CA5B KA '=' 3 uM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki '=' 12589 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 5623 nM
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 Emax '=' 100 %
Q50565 BXGT014936 Carbonic anhydrase unreviewed - MTH_1582 Ka '=' 76 uM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Kcat '=' 12 10^5/s
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Km '=' 9300000 nM
Q6FTL6 BXGT016286 Carbonic anhydrase unreviewed - NCE103 Km '=' 7900000 nM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 Selectivity '=' 1 -
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 pD2 '=' 6 -
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 Intrinsic activity '=' 1 -
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Relative activity '=' 105 %
Q3I4V7 BXGT014421 Carbonic anhydrase unreviewed - CAN2 Km '=' 9000000 nM
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 EC50 '=' 199 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Effect '=' - -
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 891 nM
Q5AJ71 BXGT015288 Carbonic anhydrase reviewed - NCE103 Kcat '=' 20 10'5/s
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 12 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 44668 nM
Q63089 BXGT016060 Solute carrier family 22 member 1 reviewed - Slc22a1 Ki '=' 141000 nM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 EC50 '=' 5 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 Ki '=' 12 nM
O15244 BXGT004140 Solute carrier family 22 member 2 reviewed Transporter SLC22A2 Activity - - -
O75751 BXGT005150 Solute carrier family 22 member 3 reviewed Transporter SLC22A3 Ki '=' 140000 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 - - -
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 Activity '=' 1 -
Q5AJ71 BXGT015288 Carbonic anhydrase reviewed - NCE103 Km '=' 8200000 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 Ki '=' 1 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 9 nM
Q6FTL6 BXGT016286 Carbonic anhydrase unreviewed - NCE103 Ka '=' 27 uM
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Relative potency '=' 100 -
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 EC50 '=' 1202 nM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 EC50 '=' 640 nM
Q5AJ71 BXGT015288 Carbonic anhydrase reviewed - NCE103 Kcat '=' 8 10'5/s
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 10621 nM
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 EC50 '=' 650 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 12 nM
Q9ULX7 BXGT021769 Carbonic anhydrase 14 reviewed - CA14 Kcat '=' 10 10^5/s
P31390 BXGT009534 Histamine H1 receptor reviewed - Hrh1 EC50 '=' 4466 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 Ki '=' 60 nM
P35218 BXGT009796 Carbonic anhydrase 5A, mitochondrial reviewed - CA5A KA '=' 0 uM
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki '=' 2 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 89125 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Kcat '=' 2 10^6/s
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 - - -
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 pD2 '=' 5 -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 EC50 '=' 1258 nM
P22748 BXGT008802 Carbonic anhydrase 4 reviewed - CA4 Ka '=' 31 uM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 EC50 '=' 88 nM
P43166 BXGT010364 Carbonic anhydrase 7 reviewed - CA7 Ka '=' 1 uM
P31390 BXGT009534 Histamine H1 receptor reviewed - Hrh1 Relative potency '=' 100 -
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 13 nM
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 EC50 '=' 1200 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 11 nM
Q9JI35 BXGT020813 Histamine H3 receptor reviewed - HRH3 Ki '=' 10 nM
P47747 BXGT010583 Histamine H2 receptor reviewed - HRH2 Effect '=' - -
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Potency '=' 100 -
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 pD2 '=' 6 -
Q9QYN8 BXGT021392 Histamine H3 receptor reviewed - Hrh3 Antagonist activity - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki '=' 1 nM
Q9ULX7 BXGT021769 Carbonic anhydrase 14 reviewed - CA14 KA '=' 0 uM
P25102 BXGT009019 Histamine H2 receptor reviewed - Hrh2 Kd '=' 117489 nM
Q7RTT9 BXGT017086 Equilibrative nucleoside transporter 4 reviewed Transporter SLC29A4 K0.5 '=' 10 mM
Q7RTT9 BXGT017086 Equilibrative nucleoside transporter 4 reviewed Transporter SLC29A4 Activity '=' -30 nanoampere
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Activity '=' 185 %
P31390 BXGT009534 Histamine H1 receptor reviewed - Hrh1 Kd '=' 10 nM
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 EC50 '=' 8 nM
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 pKb '=' 9 -
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Relative activity '=' 100 %
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 EC50 '=' 13 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 25 nM
Q91ZY2 BXGT019330 Histamine H4 receptor reviewed - Hrh4 Ki '=' 42 nM
Q91ZY1 BXGT019329 Histamine H4 receptor reviewed - Hrh4 Ki '=' 136 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki '=' 6000 nM
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 EC50 '=' 162 nM
P31390 BXGT009534 Histamine H1 receptor reviewed - Hrh1 Emax '=' 100 %
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 Ki '=' 8 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Activity '=' 175 %
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 19 nM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 EC50 '=' 4 nM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 Efficacy '=' 1 -
Q9UIF8 BXGT021718 Bromodomain adjacent to zinc finger domain protein 2B reviewed - BAZ2B Potency - 79432 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 '=' 158 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 Ki '=' 13 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 - - -
Q7RTT9 BXGT017086 Equilibrative nucleoside transporter 4 reviewed Transporter SLC29A4 Activity '=' -110 nanoampere
Q9R0W2 BXGT021408 Solute carrier family 22 member 2 reviewed - Slc22a2 Ki '=' 390000 nM
Q9ULX7 BXGT021769 Carbonic anhydrase 14 reviewed - CA14 Ka '=' 1 uM
Q5AJ71 BXGT015288 Carbonic anhydrase reviewed - NCE103 KA '=' 18 uM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 20 nM
P35218 BXGT009796 Carbonic anhydrase 5A, mitochondrial reviewed - CA5A Kcat '=' 8 10^5/s
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 - - -
Q9R0W2 BXGT021408 Solute carrier family 22 member 2 reviewed - Slc22a2 Km '=' 278000 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 8436 nM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 Ki '=' 12 nM
O75751 BXGT005150 Solute carrier family 22 member 3 reviewed Transporter SLC22A3 Km '=' 180000 nM
Q9R0W2 BXGT021408 Solute carrier family 22 member 2 reviewed - Slc22a2 Ki '=' 171000 nM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 Ki '=' 5 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 11 nM
Q9R0W2 BXGT021408 Solute carrier family 22 member 2 reviewed - Slc22a2 Km '=' 540000 nM
Q7RTT9 BXGT017086 Equilibrative nucleoside transporter 4 reviewed Transporter SLC29A4 FC '=' 2 -
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 11 nM
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 Ki '=' 16 nM
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki '=' 5000 nM
Q63089 BXGT016060 Solute carrier family 22 member 1 reviewed - Slc22a1 Km '=' 300000 nM
Q91ZY3 BXGT019331 Histamine H4 receptor unreviewed - HRH4 Ki '=' 6 nM
Q9QYN8 BXGT021392 Histamine H3 receptor reviewed - Hrh3 Ki '=' 6 nM
Q9JI35 BXGT020813 Histamine H3 receptor reviewed - HRH3 Ki '=' 0 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 Ki '=' 15 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 7 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 '~' 1000 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 Ki '=' 4 nM
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 EC50 '=' 13 nM
Q4CVY4 BXGT026093 Carbonic anhydrase-like protein, putative unreviewed - Tc00.1047053509597.20 KA '=' 2 uM
P40881 BXGT010205 Carbonic anhydrase reviewed - KA '=' 63 uM
Q91ZY2 BXGT019330 Histamine H4 receptor reviewed - Hrh4 EC50 '=' 94 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00148 Almond Prunus dulcis Nuts
BXGF00178 Spinach Spinacia oleracea Vegetables
BXGF01147 Chelidonium majus Chelidonium majus Medicinal Plant
BXGF01848 Pyrus pyraster Pyrus pyraster Medicinal Plant
BXGF02091 Dichrostachys cinerea Dichrostachys cinerea Medicinal Plant
BXGF02094 Astragalus oxyphysus Astragalus oxyphysus Others
BXGF02497 Hydrodictyon reticulatum Hydrodictyon reticulatum Human Edible Plant
BXGF02801 Senecio candollei Senecio candollei Others
BXGF02849 Polyscias scutellaria Polyscias scutellaria Medicinal Plant
BXGF02871 Centaurea glastifolia Centaurea glastifolia Others
BXGF02902 Grindelia havardii Grindelia havardii Others
BXGF02918 Nephelium maingayi Nephelium maingayi Human Edible Plant
BXGF02934 Galanthus nivalis Galanthus nivalis Medicinal Plant
BXGF02954 Euphorbia armena Euphorbia armena Others
BXGF03580 Urtica dioica Urtica dioica Medicinal Plant
BXGF06109 Cuscuta reflexa Cuscuta reflexa Medicinal Plant
BXGF06113 Plantago depressa Plantago depressa Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease