Showing entry for Solute carrier family 22 member 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004140
Protein NameSolute carrier family 22 member 2
Uniport IdO15244
GeneSLC22A2
Gene Id6582
DomainSugar_tr
Pfam PF00083  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.1 Cancers: Overview hsa05231 Choline metabolism in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0015837 amine transport
Biological Process GO:0089718 amino acid import across plasma membrane
Biological Process GO:0007589 body fluid secretion
Biological Process GO:0015871 choline transport
Biological Process GO:0090494 dopamine uptake
Biological Process GO:0006855 drug transmembrane transport
Biological Process GO:0140115 export across plasma membrane
Biological Process GO:0051615 histamine uptake
Biological Process GO:1902475 L-alpha-amino acid transmembrane transport
Biological Process GO:0097638 L-arginine import across plasma membrane
Biological Process GO:0042136 neurotransmitter biosynthetic process
Biological Process GO:0007269 neurotransmitter secretion
Biological Process GO:0006836 neurotransmitter transport
Biological Process GO:0051620 norepinephrine uptake
Biological Process GO:0015695 organic cation transport
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0051610 serotonin uptake
Biological Process GO:1901998 toxin transport
Biological Process GO:0150104 transport across blood-brain barrier
Biological Process GO:0042908 xenobiotic transport
Biological Process GO:1990962 xenobiotic transport across blood-brain barrier
molecular function GO:0005275 amine transmembrane transporter activity
molecular function GO:0015220 choline transmembrane transporter activity
molecular function GO:0015562 efflux transmembrane transporter activity
molecular function GO:0015179 L-amino acid transmembrane transporter activity
molecular function GO:0061459 L-arginine transmembrane transporter activity
molecular function GO:0008504 monoamine transmembrane transporter activity
molecular function GO:0005326 neurotransmitter transmembrane transporter activity
molecular function GO:0015101 organic cation transmembrane transporter activity
molecular function GO:0019534 toxin transmembrane transporter activity
molecular function GO:0042910 xenobiotic transmembrane transporter activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0098793 presynapse
Reactome
Pathway Id Pathway Name
R-HSA-112310 Neurotransmitter release cycle
R-HSA-112311 Neurotransmitter clearance
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1430728 Metabolism
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-2161517 Abacavir transmembrane transport
R-HSA-2161522 Abacavir transport and metabolism
R-HSA-382551 Transport of small molecules
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-549127 Organic cation transport
R-HSA-549132 Organic cation/anion/zwitterion transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004059 BXGD000250 aspirin intolerance
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0005398 BXGD000311 Cholestasis, Extrahepatic Digestive System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008372 BXGD000535 Intrahepatic Cholestasis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0017654 BXGD001136 Glomerular Filtration Rate
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023485 BXGD001667 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024408 BXGD001768 Machado-Joseph Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0031039 BXGD002274 Pericardial effusion Cardiovascular Diseases
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0149678 BXGD003346 Epstein-Barr Virus Infections Infections
C0150055 BXGD003401 Chronic pain Pathological Conditions, Signs and Symptoms
C0152459 BXGD003600 Linear atrophy Pathological Conditions, Signs and Symptoms
C0201976 BXGD004063 Creatinine measurement, serum (procedure)
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0220597 BXGD004292 Adult Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220644 BXGD004306 Childhood Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0233401 BXGD004575 Psychiatric symptom
C0238052 BXGD004866 Xanthomatosis, Cerebrotendinous Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0334517 BXGD007099 Spermatocytic seminoma Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0334663 BXGD007149 Histiocytic sarcoma Neoplasms; Hemic and Lymphatic Diseases
C0349632 BXGD007939 Splenic Marginal Zone B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0392788 BXGD008070 Nasal Type Extranodal NK/T-Cell Lymphoma Neoplasms
C0428279 BXGD008623 Finding of creatinine level
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0687131 BXGD009838 Psychoticism
C0740394 BXGD009989 Hyperuricemia Pathological Conditions, Signs and Symptoms
C0795692 BXGD010730 Hyperlactatemia Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1096202 BXGD011610 Lipoprotein (a) measurement
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1292753 BXGD012226 Primary Effusion Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1292754 BXGD012227 Mediastinal (Thymic) Large B-Cell Lymphoma Neoplasms; Respiratory Tract Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C1292769 BXGD012230 Precursor B-cell lymphoblastic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1321547 BXGD012435 T-cell/histiocyte rich large B-cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332922 BXGD012556 Cervical Squamous Intraepithelial Neoplasia Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1333064 BXGD012587 Classical Hodgkin's Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1334968 BXGD012749 Nodular Lymphocyte Predominant Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1868683 BXGD016526 B-CELL MALIGNANCY, LOW-GRADE
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2347747 BXGD017040 Adult Classical Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2609414 BXGD017182 Acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2955673 BXGD018191 Urate nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4055183 BXGD021997 Contrast - Induced Nephropathy
C4285807 BXGD022455 Behavioral and psychological symptoms of dementia
C4721579 BXGD023759 Secondary malignant neoplasm of colon and/or rectum Digestive System Diseases; Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000130 Estradiol 272.38
BXGC0000409 Choline 104.17
BXGC0001325 Progesterone 314.46
BXGC0002627 17alpha-ethynylestradiol 296.4
BXGC0002796 Nicotine 162.23
BXGC0003196 Aripiprazole 448.39
BXGC0003342 Guanidine 59.07
BXGC0004285 Agmatine 130.19
BXGC0004358 Thiamine 265.36
BXGC0005398 (-)-alpha-Narcotine 413.42
BXGC0005867 Serotonin 176.22
BXGC0005871 Dopamine 153.18
BXGC0012292 Creatinine 113.12
BXGC0013854 Histamine 111.08
BXGC0015879 Chlorhexidine 504.2
BXGC0020800 Testosterone 288.21
BXGC0021893 Norepinephrine 169.07
BXGC0030663 Metformin 129.1
BXGC0034941 Combretastatin A4 316.13
BXGC0035201 Quinidine 324.18
BXGC0042222 Propranolol 259.16
BXGC0052646 Tubocurarine 609.3
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein