Showing entry for Synaptic vesicular amine transporter


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012846
Protein NameSynaptic vesicular amine transporter
Uniport IdQ05940
GeneSLC18A2
Gene Id6571
DomainMFS_1
Pfam PF07690  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.6 Nervous system hsa04721 Synaptic vesicle cycle
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
5. Organismal Systems 5.6 Nervous system hsa04728 Dopaminergic synapse
6. Human Diseases 6.4 Neurodegenerative diseases hsa05012 Parkinson disease
6. Human Diseases 6.5 Substance dependence hsa05030 Cocaine addiction
6. Human Diseases 6.5 Substance dependence hsa05031 Amphetamine addiction
6. Human Diseases 6.5 Substance dependence hsa05034 Alcoholism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015842 aminergic neurotransmitter loading into synaptic vesicle
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0015872 dopamine transport
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0015844 monoamine transport
Biological Process GO:1903427 negative regulation of reactive oxygen species biosynthetic process
Biological Process GO:0098700 neurotransmitter loading into synaptic vesicle
Biological Process GO:0007269 neurotransmitter secretion
Biological Process GO:0006836 neurotransmitter transport
Biological Process GO:0009791 post-embryonic development
Biological Process GO:0001975 response to amphetamine
Biological Process GO:0009636 response to toxic substance
Biological Process GO:0042137 sequestering of neurotransmitter
molecular function GO:0008504 monoamine transmembrane transporter activity
molecular function GO:0005335 serotonin:sodium symporter activity
molecular function GO:0022857 transmembrane transporter activity
cellular component GO:0005813 centrosome
cellular component GO:0070083 clathrin-sculpted monoamine transport vesicle membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0008021 synaptic vesicle
cellular component GO:0030672 synaptic vesicle membrane
cellular component GO:0043195 terminal bouton
Reactome
Pathway Id Pathway Name
R-HSA-112310 Neurotransmitter release cycle
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-382551 Transport of small molecules
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006012 BXGD000360 Borderline Personality Disorder Mental Disorders
C0006287 BXGD000390 Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007112 BXGD000429 Adenocarcinoma of prostate Neoplasms; Male Urogenital Diseases
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013363 BXGD000818 Dysautonomia Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0016506 BXGD001062 Foot Deformities Musculoskeletal Diseases
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0019562 BXGD001336 Von Hippel-Lindau Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0023976 BXGD001724 Long QT Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0024408 BXGD001768 Machado-Joseph Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0025268 BXGD001846 Multiple Endocrine Neoplasia Type 2a Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0027651 BXGD002009 Neoplasms Neoplasms
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030421 BXGD002218 Paraganglioma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0038450 BXGD002759 Stridor Pathological Conditions, Signs and Symptoms
C0038580 BXGD002771 Substance Dependence Chemically-Induced Disorders; Mental Disorders
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042345 BXGD002977 Varicosity Cardiovascular Diseases
C0042900 BXGD003012 Vitiligo Skin and Connective Tissue Diseases
C0085281 BXGD003152 Addictive Behavior Behavior and Behavior Mechanisms
C0085637 BXGD003219 Oculogyric crisis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152115 BXGD003544 Lingual-Facial-Buccal Dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0221271 BXGD004431 Elastosis perforans serpiginosa Skin and Connective Tissue Diseases
C0231688 BXGD004510 Gait, Shuffling Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234979 BXGD004707 Dysdiadochokinesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235032 BXGD004715 Neurotoxicity Syndromes Nervous System Diseases; Chemically-Induced Disorders
C0236701 BXGD004821 Cocaine-induced mood disorder Chemically-Induced Disorders; Mental Disorders
C0236734 BXGD004823 Caffeine related disorders
C0236969 BXGD004842 Substance-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0241657 BXGD005105 Abnormality of the vasculature Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Cardiovascular Diseases
C0241726 BXGD005110 Delayed ability to walk
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0242423 BXGD005164 Ramsay Hunt Paralysis Syndrome Nervous System Diseases
C0270458 BXGD006075 Severe major depression with psychotic features Mental Disorders; Behavior and Behavior Mechanisms
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0362046 BXGD007959 Prediabetes syndrome Nutritional and Metabolic Diseases; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0497202 BXGD009055 Abnormal ocular motility
C0520966 BXGD009128 Abnormal coordination Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524662 BXGD009238 Opiate Addiction Chemically-Induced Disorders; Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0557874 BXGD009444 Global developmental delay
C0566620 BXGD009490 Nasal voice
C0575059 BXGD009510 Spastic tetraparesis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0600427 BXGD009706 Cocaine Dependence Chemically-Induced Disorders; Mental Disorders
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686347 BXGD009832 Tardive Dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0740858 BXGD010012 Substance abuse problem Chemically-Induced Disorders; Mental Disorders
C0743072 BXGD010073 Depression, psychotic Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0748607 BXGD010201 Recurrent seizure Nervous System Diseases
C0751093 BXGD010317 Dystonia, Limb Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751837 BXGD010604 Gait Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752097 BXGD010659 Autosomal Dominant Juvenile Parkinson Disease Nervous System Diseases
C0752098 BXGD010660 Autosomal Dominant Parkinsonism Nervous System Diseases
C0752100 BXGD010661 Autosomal Recessive Parkinsonism Nervous System Diseases
C0752101 BXGD010662 Parkinsonism, Experimental Nervous System Diseases
C0752104 BXGD010663 Familial Juvenile Parkinsonism Nervous System Diseases
C0752105 BXGD010664 Parkinsonism, Juvenile Nervous System Diseases
C0752121 BXGD010669 Spinocerebellar Ataxia Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0809983 BXGD010840 Schizophrenia and related disorders Mental Disorders
C0813217 BXGD010854 Expressionless face Nervous System Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0860609 BXGD011237 Inappropriate crying
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1285162 BXGD012167 Degenerative disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1510472 BXGD013170 Drug Dependence Chemically-Induced Disorders; Mental Disorders
C1820737 BXGD013762 Temperature instability
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1840333 BXGD014449 Barakat syndrome Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases; Endocrine System Diseases; Otorhinolaryngologic Diseases
C1847514 BXGD014868 Postnatal microcephaly
C1847835 BXGD014892 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) Skin and Connective Tissue Diseases
C1850100 BXGD015108 PARKINSON DISEASE 15, AUTOSOMAL RECESSIVE (disorder) Eye Diseases; Nervous System Diseases
C1851920 BXGD015246 Dopa-Responsive Dystonia Nervous System Diseases
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1862941 BXGD016145 Amyotrophic Lateral Sclerosis, Sporadic Nutritional and Metabolic Diseases; Nervous System Diseases
C1868675 BXGD016520 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE Nervous System Diseases
C1868684 BXGD016527 EAR, PATELLA, SHORT STATURE SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3160718 BXGD018468 PARKINSON DISEASE, LATE-ONSET
C3272399 BXGD018620 Gastric Neuroendocrine Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C3714760 BXGD019432 Drug-induced tardive dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Chemically-Induced Disorders
C3887506 BXGD019886 Hyperkinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021085 BXGD020544 Abnormality of brain morphology
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4275179 BXGD022368 Young onset Parkinson disease Nervous System Diseases
C4303546 BXGD022565 Brain dopamine-serotonin vesicular transport disease Nervous System Diseases
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4476759 BXGD022861 Stooped posture Nervous System Diseases
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4747991 BXGD023977 PARKINSONISM-DYSTONIA, INFANTILE, 2
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001327 Nonacosan-8-one 165.23
BXGC0005867 Serotonin 176.22
BXGC0005871 Dopamine 153.18
BXGC0013854 Histamine 111.08
BXGC0014068 Amphetamine 135.1
BXGC0021893 Norepinephrine 169.07
BXGC0038169 (-)-Lobeline 337.2
BXGC0052374 Reserpine 608.27
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein