Showing entry for Taxifolin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0043125
Compound NameTaxifolin
Structure
FormulaC15H12O7
InchiKeyCXQWRCVTCMQVQX-UHFFFAOYSA-N
SMILESOc1cc2OC(c3ccc(c(c3)O)O)C(C(=O)c2c(c1)O)O
InchiInChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H
IUPAC2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one
Molecular Weight304.06
Pubchem Id471
Chembl IdCHEMBL337309
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
CHEMBL CHEMBL337309
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
O75496 BXGT005132 Geminin reviewed - GMNN Potency '=' 31622 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 8436 nM
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ke '=' 3820 nM
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 1888 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 35481 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 9528 nM
P39900 BXGT010148 Macrophage metalloelastase reviewed Enzyme MMP12 Inhibition '>' 30 %
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 31622 nM
P21447 BXGT008651 ATP-dependent translocase ABCB1 reviewed - Abcb1a Kd '=' 37400 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 2667 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 8 nM
P07378 BXGT006616 Phosphoglycerate kinase, glycosomal reviewed - Potency - 26854 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 5972 nM
P05164 BXGT006333 Myeloperoxidase reviewed Enzyme MPO Inhibition '=' 40 %
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 1584 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 3981 nM
P28907 BXGT009301 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 reviewed Enzyme CD38 IC50 '>' 100000 nM
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 Activity '=' 108 %
P15289 BXGT008102 Arylsulfatase A reviewed Enzyme ARSA Potency - 239 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Inhibition '=' 17 %
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ke '=' 3280 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 25118 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 4466 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 10000 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 8912 nM
Q60795 BXGT016000 Nuclear factor erythroid 2-related factor 2 reviewed - Nfe2l2 Activity - - -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 pKi(uM) - - -
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a pKi(uM) - - -
P47989 BXGT010602 Xanthine dehydrogenase/oxidase reviewed Enzyme XDH IC50 '>' 100000 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 5623 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Displacement '<' 10 %
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 1000 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 pKi(uM) '=' -1 -
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki '=' 34100 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 28183 nM
P00489 BXGT005553 Glycogen phosphorylase, muscle form reviewed - PYGM IC50 '=' 20900 nM
P11511 BXGT007717 Aromatase reviewed Enzyme CYP19A1 Activity '=' 90 %
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 36 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 15848 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 35481 nM
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 43700 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 43700 nM
P00489 BXGT005553 Glycogen phosphorylase, muscle form reviewed - PYGM IC50 '=' 4800 nM
Q60795 BXGT016000 Nuclear factor erythroid 2-related factor 2 reviewed - Nfe2l2 FC '=' 1 -
P08253 BXGT006757 72 kDa type IV collagenase reviewed Enzyme MMP2 IC50 '=' 22620 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 3548 nM
P08253 BXGT006757 72 kDa type IV collagenase reviewed Enzyme MMP2 Inhibition '>' 30 %
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP reviewed - HSPA5 Potency - 28183 nM
Q01453 BXGT012588 Peripheral myelin protein 22 reviewed Cellular structure PMP22 Potency '=' 75686 nM
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Inhibition '>' 30 %
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Ki '>' 10000 nM
P0A6C1 BXGT007045 Endonuclease 4 reviewed - nfo Potency '=' 25118 nM
P36888 BXGT009938 Receptor-type tyrosine-protein kinase FLT3 reviewed Kinase FLT3 IC50 '>' 10000 nM
P08254 BXGT006758 Stromelysin-1 reviewed Enzyme MMP3 IC50 '=' 33910 nM
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 '=' 32020 nM
P00591 BXGT005592 Pancreatic triacylglycerol lipase reviewed - PNLIP Inhibition - - -
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 6012 nM
P45452 BXGT010462 Collagenase 3 reviewed Enzyme MMP13 IC50 '=' 34600 nM
P39900 BXGT010148 Macrophage metalloelastase reviewed Enzyme MMP12 IC50 '=' 5750 nM
P08254 BXGT006758 Stromelysin-1 reviewed Enzyme MMP3 Inhibition '>' 30 %
P45452 BXGT010462 Collagenase 3 reviewed Enzyme MMP13 Inhibition '>' 30 %
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 26679 nM
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ke '=' 3070 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 39810 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 39810 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 37685 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 Inhibition '=' 19 %
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki '>' 10000 nM
P43166 BXGT010364 Carbonic anhydrase 7 reviewed - CA7 Ki '=' 493 nM
O43570 BXGT004601 Carbonic anhydrase 12 reviewed - CA12 Ki '=' 32 nM
P22748 BXGT008802 Carbonic anhydrase 4 reviewed - CA4 Ki '=' 9098 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00183 Common thyme Thymus vulgaris Herbs and Spices
BXGF00369 Sacred lotus Nelumbo nucifera Vegetables
BXGF01324 Albizia julibrissin Albizia julibrissin Medicinal Plant
BXGF01341 Trachelospermum jasminoides Trachelospermum jasminoides Medicinal Plant
BXGF01506 Thymus quinquecostatus Thymus quinquecostatus Medicinal Plant
BXGF01721 Humulus lupulus Humulus lupulus Medicinal Plant
BXGF01806 Rhododendron mucronatum Rhododendron mucronatum Medicinal Plant
BXGF01910 Trachelospermum asiaticum Trachelospermum asiaticum Medicinal Plant
BXGF02543 Rhododendron mucronulatum Rhododendron mucronulatum Medicinal Plant
BXGF02551 Inula britannica Inula britannica Medicinal Plant
BXGF02604 Agrimonia pilosa Agrimonia pilosa Medicinal Plant
BXGF03189 Rhododendron dauricum Rhododendron dauricum Medicinal Plant
BXGF03610 Bistorta officinalis Bistorta officinalis Medicinal Plant
BXGF03791 Pistacia chinensis Pistacia chinensis Medicinal Plant
BXGF04053 Smilax china Smilax china Medicinal Plant
BXGF04062 Spatholobus suberectus Spatholobus suberectus Medicinal Plant
BXGF04080 Persicaria orientalis Persicaria orientalis Medicinal Plant
BXGF04224 Bistorta manshuriensis Bistorta manshuriensis Others
BXGF04607 Morus alba Morus alba Medicinal Plant
BXGF04953 Polygonum aviculare Polygonum aviculare Medicinal Plant
BXGF05302 Lippia sidoides Lippia sidoides Others
BXGF05693 Picea jezoensis var. jezoensis Picea jezoensis var. jezoensis Medicinal Plant
BXGF05728 Persicaria perfoliata Persicaria perfoliata Medicinal Plant
BXGF05787 Smilax glabra Smilax glabra Medicinal Plant
BXGF06156 Inula japonica Inula japonica Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease