Showing entry for Polycystin-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013377
Protein NamePolycystin-2
Uniport IdQ13563
GenePKD2
Gene Id5311
DomainPKD_channel
Pfam PF08016  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0035904 aorta development
Biological Process GO:0001658 branching involved in ureteric bud morphogenesis
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0198738 cell-cell signaling by wnt
Biological Process GO:0007050 cell cycle arrest
Biological Process GO:0071277 cellular response to calcium ion
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0071498 cellular response to fluid shear stress
Biological Process GO:0071464 cellular response to hydrostatic pressure
Biological Process GO:0071470 cellular response to osmotic stress
Biological Process GO:0034614 cellular response to reactive oxygen species
Biological Process GO:0051298 centrosome duplication
Biological Process GO:0044782 cilium organization
Biological Process GO:0042994 cytoplasmic sequestering of transcription factor
Biological Process GO:0050982 detection of mechanical stimulus
Biological Process GO:0003127 detection of nodal flow
Biological Process GO:0007368 determination of left/right symmetry
Biological Process GO:0071910 determination of liver left/right asymmetry
Biological Process GO:0001892 embryonic placenta development
Biological Process GO:0007507 heart development
Biological Process GO:0001947 heart looping
Biological Process GO:0098662 inorganic cation transmembrane transport
Biological Process GO:0001889 liver development
Biological Process GO:0072177 mesonephric duct development
Biological Process GO:0072164 mesonephric tubule development
Biological Process GO:0072218 metanephric ascending thin limb development
Biological Process GO:0072214 metanephric cortex development
Biological Process GO:0072219 metanephric cortical collecting duct development
Biological Process GO:0072235 metanephric distal tubule development
Biological Process GO:0072075 metanephric mesenchyme development
Biological Process GO:0035502 metanephric part of ureteric bud development
Biological Process GO:0072208 metanephric smooth muscle tissue development
Biological Process GO:0072284 metanephric S-shaped body morphogenesis
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
Biological Process GO:0021915 neural tube development
Biological Process GO:0060674 placenta blood vessel development
Biological Process GO:0071158 positive regulation of cell cycle arrest
Biological Process GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:0051290 protein heterotetramerization
Biological Process GO:0051289 protein homotetramerization
Biological Process GO:0051262 protein tetramerization
Biological Process GO:0007259 receptor signaling pathway via JAK-STAT
Biological Process GO:0090279 regulation of calcium ion import
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0051209 release of sequestered calcium ion into cytosol
Biological Process GO:0061441 renal artery morphogenesis
Biological Process GO:0061333 renal tubule morphogenesis
Biological Process GO:0035725 sodium ion transmembrane transport
Biological Process GO:0021510 spinal cord development
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0042805 actinin binding
molecular function GO:0051117 ATPase binding
molecular function GO:0048763 calcium-induced calcium release activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0005261 cation channel activity
molecular function GO:0008092 cytoskeletal protein binding
molecular function GO:0043398 HLH domain binding
molecular function GO:0042802 identical protein binding
molecular function GO:0044325 ion channel binding
molecular function GO:0051371 muscle alpha-actinin binding
molecular function GO:0015271 outward rectifier potassium channel activity
molecular function GO:0051219 phosphoprotein binding
molecular function GO:0005267 potassium channel activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0005102 signaling receptor binding
molecular function GO:0005245 voltage-gated calcium channel activity
molecular function GO:0022843 voltage-gated cation channel activity
molecular function GO:0005244 voltage-gated ion channel activity
molecular function GO:0005249 voltage-gated potassium channel activity
molecular function GO:0005248 voltage-gated sodium channel activity
cellular component GO:0045180 basal cortex
cellular component GO:0009925 basal plasma membrane
cellular component GO:0034703 cation channel complex
cellular component GO:0005911 cell-cell junction
cellular component GO:0036064 ciliary basal body
cellular component GO:0060170 ciliary membrane
cellular component GO:0005929 cilium
cellular component GO:0005737 cytoplasm
cellular component GO:0030659 cytoplasmic vesicle membrane
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0005794 Golgi apparatus
cellular component GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane
cellular component GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0030027 lamellipodium
cellular component GO:0016020 membrane
cellular component GO:0072686 mitotic spindle
cellular component GO:0031514 motile cilium
cellular component GO:0097730 non-motile cilium
cellular component GO:0005886 plasma membrane
cellular component GO:0002133 polycystin complex
Reactome
Pathway Id Pathway Name
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-5617833 Cilium Assembly
R-HSA-5617833 Cilium Assembly
R-HSA-5620916 VxPx cargo-targeting to cilium
R-HSA-5620916 VxPx cargo-targeting to cilium
R-HSA-5620920 Cargo trafficking to the periciliary membrane
R-HSA-5620920 Cargo trafficking to the periciliary membrane
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0003868 BXGD000233 Arthritis, Gouty Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004245 BXGD000264 Atrioventricular Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007766 BXGD000478 Intracranial Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009782 BXGD000631 Connective Tissue Diseases Skin and Connective Tissue Diseases
C0010709 BXGD000689 Cyst Pathological Conditions, Signs and Symptoms; Neoplasms
C0011813 BXGD000748 Dextrocardia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0014511 BXGD000920 Epithelial cyst Neoplasms
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0017668 BXGD001143 Focal glomerulosclerosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018099 BXGD001172 Gout Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019269 BXGD001310 Hermaphroditism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020544 BXGD001426 Renal hypertension Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0021290 BXGD001491 Neonatal disorder Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022679 BXGD001575 Cystic kidney Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022680 BXGD001576 Polycystic Kidney Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030283 BXGD002200 Pancreatic Cyst Digestive System Diseases; Neoplasms
C0030286 BXGD002201 Pancreatic Diseases Digestive System Diseases
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0037221 BXGD002673 Situs Inversus Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0043194 BXGD003036 Wiskott-Aldrich Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0085413 BXGD003171 Polycystic Kidney, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085548 BXGD003183 Autosomal Recessive Polycystic Kidney Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0158683 BXGD003899 Polycystic liver disease Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Neoplasms
C0202239 BXGD004087 Uric acid measurement (procedure)
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0236734 BXGD004823 Caffeine related disorders
C0238286 BXGD004904 Mucolipidosis Type IV Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0243050 BXGD005212 Cardiovascular Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0262655 BXGD005264 Recurrent urinary tract infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0265110 BXGD005455 Cerebral Vasospasm Nervous System Diseases; Cardiovascular Diseases
C0266642 BXGD005705 Situs ambiguus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0267834 BXGD005784 Liver cyst Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Neoplasms
C0268800 BXGD006041 Simple renal cyst Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0270715 BXGD006089 Degenerative Diseases, Central Nervous System Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0280324 BXGD006740 Laryngeal Squamous Cell Carcinoma Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0311245 BXGD006869 Congenital cystic kidney disease Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0334054 BXGD006984 cystic disease
C0340643 BXGD007357 Dissection of aorta Cardiovascular Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376634 BXGD008006 Craniofacial Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0394006 BXGD008166 Dysequilibrium syndrome Nervous System Diseases
C0398368 BXGD008188 Lymphatic Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0685938 BXGD009829 Malignant neoplasm of gastrointestinal tract Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700225 BXGD009882 Serum creatinine raised Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751733 BXGD010569 Degenerative Diseases, Spinal Cord Nervous System Diseases
C0887850 BXGD011399 Polycystic Kidney, Type 1 Autosomal Dominant Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0950121 BXGD011590 Denys-Drash Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1319317 BXGD012416 Squamous cell carcinoma of pharynx Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1567435 BXGD013413 Polycystic Kidney - body part Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1691228 BXGD013492 Cystic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1840374 BXGD014456 Elevated systolic blood pressure Cardiovascular Diseases
C1840375 BXGD014457 Elevated diastolic blood pressure Cardiovascular Diseases
C1865974 BXGD016358 Hypomagnesemia 1, Intestinal Nutritional and Metabolic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316787 BXGD017029 Chronic kidney disease stage 3 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2317473 BXGD017034 Chronic kidney disease stage 4 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2609414 BXGD017182 Acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2673195 BXGD017188 Angiopathy, Hereditary, With Nephropathy, Aneurysms, And Muscle Cramps Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C2751306 BXGD017701 Polycystic kidney disease, type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2931174 BXGD017969 Polycystic kidney disease, type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3149841 BXGD018287 POLYCYSTIC KIDNEY DISEASE 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714581 BXGD019415 Multicystic Dysplastic Kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C3887499 BXGD019884 Renal cyst Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3887964 BXGD019934 POLYCYSTIC KIDNEY DISEASE 3 WITH OR WITHOUT POLYCYSTIC LIVER DISEASE
C4020705 BXGD020471 Glomerulocystic kidney disease
C4255088 BXGD022312 Isolated polycystic liver disease Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Neoplasms
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4551493 BXGD023318 Situs inversus totalis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4552000 BXGD023473 Episodic Kinesigenic Dyskinesia 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4707243 BXGD023712 Familial thoracic aortic aneurysm and aortic dissection
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0005513 Hexadecanoic acid 256.42
BXGC0038316 Cholesterol 386.35
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein