Showing entry for Cubilin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004879
Protein NameCubilin
Uniport IdO60494
GeneCUBN
Gene Id8029
DomainCUB; EGF; EGF_3; EGF_CA
Pfam PF00431   PF00008   PF12947   PF07645  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.4 Digestive system hsa04977 Vitamin digestion and absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0009235 cobalamin metabolic process
Biological Process GO:0015889 cobalamin transport
Biological Process GO:0034384 high-density lipoprotein particle clearance
Biological Process GO:0042953 lipoprotein transport
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0009617 response to bacterium
Biological Process GO:0001894 tissue homeostasis
Biological Process GO:0042359 vitamin D metabolic process
molecular function GO:0005509 calcium ion binding
molecular function GO:0038024 cargo receptor activity
molecular function GO:0031419 cobalamin binding
molecular function GO:0008144 drug binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0038023 signaling receptor activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0031526 brush border membrane
cellular component GO:0005905 clathrin-coated pit
cellular component GO:0005829 cytosol
cellular component GO:0030139 endocytic vesicle
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0010008 endosome membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0031232 extrinsic component of external side of plasma membrane
cellular component GO:0005794 Golgi apparatus
cellular component GO:0043202 lysosomal lumen
cellular component GO:0005765 lysosomal membrane
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1643685 Disease
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-HSA-196791 Vitamin D (calciferol) metabolism
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-3296469 Defects in cobalamin (B12) metabolism
R-HSA-3296482 Defects in vitamin and cofactor metabolism
R-HSA-3359462 Defective AMN causes hereditary megaloblastic anemia 1
R-HSA-3359463 Defective CUBN causes hereditary megaloblastic anemia 1
R-HSA-382551 Transport of small molecules
R-HSA-556833 Metabolism of lipids
R-HSA-5668914 Diseases of metabolism
R-HSA-8957322 Metabolism of steroids
R-HSA-8964011 HDL clearance
R-HSA-8964043 Plasma lipoprotein clearance
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001925 BXGD000090 Albuminuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002888 BXGD000145 Anemia, Megaloblastic Hemic and Lymphatic Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006370 BXGD000394 Bulimia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0009676 BXGD000619 Confusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0017668 BXGD001143 Focal glomerulosclerosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020580 BXGD001435 Hypesthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022672 BXGD001574 Acute Kidney Tubular Necrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0030554 BXGD002239 Paresthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042847 BXGD003006 Vitamin B 12 Deficiency Nutritional and Metabolic Diseases
C0080178 BXGD003107 Spina Bifida Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0151449 BXGD003419 Primary Sjögren's syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0152459 BXGD003600 Linear atrophy Pathological Conditions, Signs and Symptoms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202239 BXGD004087 Uric acid measurement (procedure)
C0202252 BXGD004089 VITAMIN B12 MEASUREMENT
C0220810 BXGD004346 Congenital defects
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236733 BXGD004822 Amphetamine-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0236804 BXGD004835 Amphetamine Addiction Chemically-Induced Disorders; Mental Disorders
C0236807 BXGD004836 Amphetamine Abuse Chemically-Induced Disorders; Mental Disorders
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278678 BXGD006556 Metastatic Renal Cell Cancer
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0342727 BXGD007534 3-@METHYLGLUTACONIC ACIDURIA, TYPE I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0346629 BXGD007831 Malignant neoplasm of large intestine Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0456844 BXGD008876 Light chain myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0497552 BXGD009067 Congenital neurologic anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0543641 BXGD009287 Megaloblastic anemia, secondary Hemic and Lymphatic Diseases
C0557874 BXGD009444 Global developmental delay
C0598608 BXGD009668 Hyperhomocysteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0730345 BXGD009960 Microalbuminuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0750292 BXGD010232 Malabsorption of Vitamin B12
C0810364 BXGD010846 Cleft Lip with or without Cleft Palate
C0850666 BXGD010901 Infection caused by Helicobacter pylori Infections
C0878681 BXGD011387 Dent's disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0920646 BXGD011471 Ischemia of kidney Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1096293 BXGD011616 Macroangiopathy
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1306856 BXGD012378 Megaloblastic anemia due to inborn errors of metabolism Hemic and Lymphatic Diseases
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1394891 BXGD012987 Intrinsic Factor Deficiency Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C1445957 BXGD013081 Serum total cholesterol measurement
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1562585 BXGD013375 Leprosy, Multibacillary Infections
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1837315 BXGD014218 COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
C1837352 BXGD014223 Childhood onset
C1969372 BXGD016775 Tubulointerstitial fibrosis
C2242817 BXGD017005 Homocysteine measurement
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2675481 BXGD017292 COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
C2677123 BXGD017364 COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
C2931852 BXGD018079 Clear-cell metastatic renal cell carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3554460 BXGD019215 COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
C3828530 BXGD019744 Platelet Component Distribution Width Measurement
C4016819 BXGD020378 MEGALOBLASTIC ANEMIA 1, FINNISH TYPE
C4025272 BXGD021615 Peripheral arterial stenosis
C4551825 BXGD023413 Megaloblastic Anemia 1 Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Hemic and Lymphatic Diseases
C4721698 BXGD023763 Metastatic Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein