Showing entry for Serotransferrin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005962
Protein NameSerotransferrin
Uniport IdP02787
GeneTF
Gene Id7018
DomainTransferrin
Pfam PF00405  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04066 HIF-1 signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04216 Ferroptosis
5. Organismal Systems 5.4 Digestive system hsa04978 Mineral absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007015 actin filament organization
Biological Process GO:0007257 activation of JUN kinase activity
Biological Process GO:0006879 cellular iron ion homeostasis
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0071281 cellular response to iron ion
Biological Process GO:0070371 ERK1 and ERK2 cascade
Biological Process GO:0055072 iron ion homeostasis
Biological Process GO:0061024 membrane organization
Biological Process GO:0030316 osteoclast differentiation
Biological Process GO:0002576 platelet degranulation
Biological Process GO:0045780 positive regulation of bone resorption
Biological Process GO:2000147 positive regulation of cell motility
Biological Process GO:0048260 positive regulation of receptor-mediated endocytosis
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0034756 regulation of iron ion transport
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:0009617 response to bacterium
Biological Process GO:0001895 retina homeostasis
Biological Process GO:0060395 SMAD protein signal transduction
Biological Process GO:0033572 transferrin transport
molecular function GO:0008199 ferric iron binding
molecular function GO:0008198 ferrous iron binding
molecular function GO:0034986 iron chaperone activity
molecular function GO:1990459 transferrin receptor binding
cellular component GO:0016324 apical plasma membrane
cellular component GO:0045178 basal part of cell
cellular component GO:0009925 basal plasma membrane
cellular component GO:0072562 blood microparticle
cellular component GO:0009986 cell surface
cellular component GO:0005905 clathrin-coated pit
cellular component GO:0030665 clathrin-coated vesicle membrane
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005769 early endosome
cellular component GO:0030139 endocytic vesicle
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0010008 endosome membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0031232 extrinsic component of external side of plasma membrane
cellular component GO:1990712 HFE-transferrin receptor complex
cellular component GO:0005770 late endosome
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0055037 recycling endosome
cellular component GO:0034774 secretory granule lumen
cellular component GO:0031982 vesicle
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-114608 Platelet degranulation
R-HSA-199991 Membrane Trafficking
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-382551 Transport of small molecules
R-HSA-392499 Metabolism of proteins
R-HSA-5653656 Vesicle-mediated transport
R-HSA-597592 Post-translational protein modification
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-917937 Iron uptake and transport
R-HSA-917977 Transferrin endocytosis and recycling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001308 BXGD000038 Acute and subacute liver necrosis (disorder) Digestive System Diseases
C0001349 BXGD000044 Acute-Phase Reaction Pathological Conditions, Signs and Symptoms
C0001430 BXGD000054 Adenoma Neoplasms
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0001956 BXGD000092 Alcohol Use Disorder Chemically-Induced Disorders; Mental Disorders
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002884 BXGD000143 Hypochromic anemia Hemic and Lymphatic Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004623 BXGD000282 Bacterial Infections Infections
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0008354 BXGD000533 Cholera Infections
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0012715 BXGD000783 Iron Metabolism Disorders Nutritional and Metabolic Diseases
C0013221 BXGD000804 Drug toxicity Chemically-Induced Disorders
C0013502 BXGD000848 Echinococcosis Infections
C0014772 BXGD000948 Red Blood Cell Count measurement
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0016053 BXGD001041 Fibromyalgia Musculoskeletal Diseases; Nervous System Diseases
C0016781 BXGD001079 Fuchs Endothelial Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018995 BXGD001265 Hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019189 BXGD001298 Hepatitis, Chronic Digestive System Diseases
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0021655 BXGD001508 Insulin Resistance Nutritional and Metabolic Diseases
C0022578 BXGD001557 Keratoconus Eye Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024667 BXGD001794 Animal Mammary Neoplasms Neoplasms; Animal Diseases
C0024668 BXGD001795 Mammary Neoplasms, Experimental Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0027626 BXGD002005 Neoplasm Invasiveness Pathological Conditions, Signs and Symptoms; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0030524 BXGD002236 Paratuberculosis Infections; Animal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0035258 BXGD002523 Restless Legs Syndrome Nervous System Diseases; Mental Disorders
C0036337 BXGD002598 Schizoaffective Disorder Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041755 BXGD002933 Adverse reaction to drug Chemically-Induced Disorders
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085136 BXGD003131 Central Nervous System Neoplasms Neoplasms; Nervous System Diseases
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0085762 BXGD003251 Alcohol abuse Chemically-Induced Disorders; Mental Disorders
C0149519 BXGD003326 Chronic Persistent Hepatitis Digestive System Diseases
C0151699 BXGD003461 Intracranial Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153633 BXGD003674 Malignant neoplasm of brain Neoplasms; Nervous System Diseases
C0162316 BXGD003936 Iron deficiency anemia Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0202105 BXGD004072 Transferrin measurement
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0205696 BXGD004107 Anaplastic carcinoma Neoplasms
C0205697 BXGD004108 Carcinoma, Spindle-Cell Neoplasms
C0205698 BXGD004109 Undifferentiated carcinoma Neoplasms
C0205699 BXGD004110 Carcinomatosis Neoplasms
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0235833 BXGD004775 Congenital diaphragmatic hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0239998 BXGD005012 Recurrent infections Pathological Conditions, Signs and Symptoms; Infections; Musculoskeletal Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0243050 BXGD005212 Cardiovascular Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0268070 BXGD005808 Hypocupremia
C0271901 BXGD006277 Microcytic hypochromic anemia (disorder) Hemic and Lymphatic Diseases
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0282193 BXGD006798 Iron Overload Nutritional and Metabolic Diseases
C0282577 BXGD006816 Congenital Disorders of Glycosylation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0302486 BXGD006847 Erythrophagocytosis
C0337439 BXGD007160 Iron measurement
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392514 BXGD008051 Hereditary hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0427460 BXGD008616 Red cell distribution width determination
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0428545 BXGD008632 Serum transferrin measurement
C0428578 BXGD008634 Iron level result
C0483368 BXGD009016 Human anaplasmosis due to Anaplasma phagocytophilum Infections; Animal Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0521802 BXGD009182 Congenital atransferrinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0524587 BXGD009232 Mean Corpuscular Volume (result)
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0546126 BXGD009328 Acute Confusional Senile Dementia Nervous System Diseases; Mental Disorders
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677932 BXGD009736 Progressive Neoplastic Disease
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0700379 BXGD009890 Total iron binding capacity function
C0750900 BXGD010241 Alzheimer's Disease, Focal Onset Nervous System Diseases; Mental Disorders
C0750901 BXGD010242 Alzheimer Disease, Early Onset Nervous System Diseases; Mental Disorders
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0867389 BXGD011300 Chronic graft-versus-host disease Immune System Diseases
C1257925 BXGD011814 Mammary Carcinoma, Animal Neoplasms; Animal Diseases
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1277709 BXGD012113 Transferrin saturation measurement
C1283048 BXGD012160 Iron binding capacity total measurement
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1318312 BXGD012392 Serum iron measurement
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1565662 BXGD013402 Acute Kidney Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2609414 BXGD017182 Acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2827503 BXGD017799 HFE-Associated Hereditary Hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3277918 BXGD018724 TRANSFERRIN SERUM LEVEL QUANTITATIVE TRAIT LOCUS 1
C3469186 BXGD018909 HEMOCHROMATOSIS, TYPE 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3539781 BXGD019086 Progressive cGVHD
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3889615 BXGD020009 TRANSFERRIN VARIANT D1 PHENOTYPE
C3889617 BXGD020010 TRANSFERRIN VARIANT B2 PHENOTYPE
C3889619 BXGD020011 TRANSFERRIN VARIANT Bv PHENOTYPE
C4021780 BXGD020775 Abnormality of the liver
C4025751 BXGD021775 Abnormality of the pancreas
C4225610 BXGD022283 TRANSFERRIN VARIANT D(CHI)
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4553297 BXGD023538 Cystic Echinocccosis Infections
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002591 Potassium 39.1
BXGC0002616 Copper 63.55
BXGC0002682 Zinc 65.41
BXGC0003533 Carbonate 60.01
BXGC0006198 Citric acid 192.12
BXGC0008661 Iron 55.85
BXGC0016470 Camptothecin 348.11
BXGC0018397 beta-1,4-mannan 180.06
BXGC0038963 Dichlorvos 219.95
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein