Showing entry for Mitofusin-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT024482
Protein NameMitofusin-2
Uniport IdO95140
GeneMFN2
Gene Id9927
DomainDynamin_N; Fzo_mitofusin
Pfam PF00350   PF04799  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04137 Mitophagy - animal
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0007596 blood coagulation
Biological Process GO:0016236 macroautophagy
Biological Process GO:0008053 mitochondrial fusion
Biological Process GO:0007006 mitochondrial membrane organization
Biological Process GO:0051646 mitochondrion localization
Biological Process GO:0046580 negative regulation of Ras protein signal transduction
Biological Process GO:0048662 negative regulation of smooth muscle cell proliferation
Biological Process GO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process
Biological Process GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
Biological Process GO:0034497 protein localization to phagophore assembly site
Biological Process GO:0006626 protein targeting to mitochondrion
Biological Process GO:0006986 response to unfolded protein
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0031625 ubiquitin protein ligase binding
cellular component GO:0005829 cytosol
cellular component GO:0016021 integral component of membrane
cellular component GO:0031306 intrinsic component of mitochondrial outer membrane
cellular component GO:0005741 mitochondrial outer membrane
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1632852 Macroautophagy
R-HSA-5205647 Mitophagy
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy
R-HSA-9612973 Autophagy
R-HSA-9663891 Selective autophagy
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003126 BXGD000180 Anosmia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003851 BXGD000226 Arteriosclerosis Obliterans Cardiovascular Diseases
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007282 BXGD000458 Carotid Stenosis Nervous System Diseases; Cardiovascular Diseases
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0008767 BXGD000570 Cicatrization Pathological Conditions, Signs and Symptoms
C0009398 BXGD000604 Color vision defect Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009691 BXGD000622 Congenital cataract Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Nervous System Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010606 BXGD000677 Adenoid Cystic Carcinoma Neoplasms
C0011195 BXGD000702 Dejerine-Sottas Disease (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0015696 BXGD001014 Fatty Liver, Alcoholic Digestive System Diseases; Chemically-Induced Disorders
C0016053 BXGD001041 Fibromyalgia Musculoskeletal Diseases; Nervous System Diseases
C0016512 BXGD001065 Foot pain Pathological Conditions, Signs and Symptoms
C0016719 BXGD001074 Friedreich Ataxia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0016781 BXGD001079 Fuchs Endothelial Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017667 BXGD001142 Nodular glomerulosclerosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019151 BXGD001290 Hepatic Encephalopathy Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0019825 BXGD001349 Hoarseness Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020071 BXGD001356 Hereditary Sensory Autonomic Neuropathy, Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021655 BXGD001508 Insulin Resistance Nutritional and Metabolic Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0023343 BXGD001635 Leprosy Infections
C0023787 BXGD001698 Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0023801 BXGD001703 Lipomatosis Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0023804 BXGD001704 Lipomatosis, Multiple Symmetrical Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027055 BXGD001964 Myocardial Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027888 BXGD002056 Hereditary Motor and Sensory Neuropathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027889 BXGD002057 Hereditary Sensory and Autonomic Neuropathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028756 BXGD002083 Obesity, Morbid Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0029132 BXGD002117 Disorder of the optic nerve Eye Diseases; Nervous System Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030554 BXGD002239 Paresthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0032181 BXGD002332 Platelet Count measurement
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0034935 BXGD002497 Babinski Reflex
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0035258 BXGD002523 Restless Legs Syndrome Nervous System Diseases; Mental Disorders
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037771 BXGD002702 Paraparesis, Spastic Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037772 BXGD002703 Spastic Paraplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0040264 BXGD002857 Tinnitus Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042928 BXGD003014 Vocal Cord Paralysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085084 BXGD003121 Motor Neuron Disease Nervous System Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085413 BXGD003171 Polycystic Kidney, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151313 BXGD003413 Sensory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152025 BXGD003521 Polyneuropathy Nervous System Diseases
C0152136 BXGD003548 Low Tension Glaucoma Eye Diseases
C0152191 BXGD003556 Scotoma, Central Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0162298 BXGD003933 Joint stiffness Musculoskeletal Diseases
C0162557 BXGD003956 Liver Failure, Acute Digestive System Diseases
C0162834 BXGD003988 Hyperpigmentation Skin and Connective Tissue Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205713 BXGD004114 Roussy-Levy Syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220636 BXGD004304 Malignant neoplasm of salivary gland Neoplasms; Stomatognathic Diseases
C0221260 BXGD004424 Dystrophia unguium Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0221505 BXGD004466 Lesion of brain
C0221629 BXGD004467 Proximal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234378 BXGD004661 Static Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235025 BXGD004713 Peripheral motor neuropathy Nervous System Diseases
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239067 BXGD004961 Difficulty walking up stairs Pathological Conditions, Signs and Symptoms
C0239377 BXGD004980 Arm Pain Pathological Conditions, Signs and Symptoms
C0239831 BXGD004999 Hand muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0239842 BXGD005001 Tremor of hands
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0240914 BXGD005063 Romberg's sign positive
C0242488 BXGD005170 Acute Lung Injury Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0260037 BXGD005227 Multiple tumors Neoplasms
C0262444 BXGD005244 Abnormality of the dentition Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0270911 BXGD006128 Charcot-Marie-Tooth Disease, Type Ia (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270914 BXGD006131 Hereditary Motor and Sensory-Neuropathy Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270921 BXGD006133 Axonal neuropathy Nervous System Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279671 BXGD006677 Cervical Squamous Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0279746 BXGD006692 Adenocarcinoma of salivary gland Neoplasms; Stomatognathic Diseases
C0282488 BXGD006804 Interstitial Cystitis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0333068 BXGD006920 Flexion contracture Musculoskeletal Diseases
C0333641 BXGD006961 Atrophic Pathological Conditions, Signs and Symptoms
C0338508 BXGD007196 Optic Atrophy 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C0340100 BXGD007304 High altitude pulmonary edema Respiratory Tract Diseases
C0340643 BXGD007357 Dissection of aorta Cardiovascular Diseases
C0342782 BXGD007549 Depletion of mitochondrial DNA
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0362046 BXGD007959 Prediabetes syndrome Nutritional and Metabolic Diseases; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392553 BXGD008055 Hereditary peripheral neuropathy Nervous System Diseases
C0393807 BXGD008147 Hereditary motor and sensory neuropathy with optic atrophy (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0393814 BXGD008149 Hereditary liability to pressure palsies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0393907 BXGD008154 Axonal sensorimotor neuropathy
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0403823 BXGD008315 Asthenozoospermia Male Urogenital Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0427065 BXGD008604 Distal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0427149 BXGD008608 Gait, Drop Foot Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0458247 BXGD008904 Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0476403 BXGD008992 Electromyogram abnormal
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0497552 BXGD009067 Congenital neurologic anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0522214 BXGD009196 Abnormal visual evoked potential Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0554970 BXGD009428 Pallor of optic disc
C0557874 BXGD009444 Global developmental delay
C0558844 BXGD009458 Knee reflex absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0558845 BXGD009459 Reflex, Ankle, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0560346 BXGD009475 Difficulty running Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0574084 BXGD009502 3-Methylglutaconic aciduria type 3 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C0574769 BXGD009505 Loss of scalp hair Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0577655 BXGD009536 Quadriceps weakness Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0587246 BXGD009616 Muscle weakness of limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0598589 BXGD009667 Inherited neuropathies Nervous System Diseases
C0600040 BXGD009684 Chronic interstitial cystitis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0600519 BXGD009712 Ventricular Remodeling Pathological Conditions, Signs and Symptoms
C0600520 BXGD009713 Left Ventricle Remodeling Pathological Conditions, Signs and Symptoms
C0677050 BXGD009714 Manganese Poisoning Nervous System Diseases; Chemically-Induced Disorders
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0745287 BXGD010125 infertility tubal factor
C0745730 BXGD010132 Multiple lipomata Neoplasms
C0748607 BXGD010201 Recurrent seizure Nervous System Diseases
C0751211 BXGD010350 Hyperalgesia, Primary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751212 BXGD010351 Hyperalgesia, Secondary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751213 BXGD010352 Tactile Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751576 BXGD010508 Partial Paralysis (Paresis) Vocal Cords Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0751602 BXGD010520 Hereditary Autosomal Dominant Spastic Paraplegia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0751651 BXGD010539 Mitochondrial Diseases Nutritional and Metabolic Diseases
C0850703 BXGD010905 Frequent falls Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0852262 BXGD010938 Placental abnormalities (excl neoplasms)
C0856169 BXGD011096 Endothelial dysfunction
C0872084 BXGD011319 Sarcopenia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0877015 BXGD011327 Pelvic Organ Prolapse Pathological Conditions, Signs and Symptoms
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0917796 BXGD011408 Optic Atrophy, Hereditary, Leber Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948750 BXGD011551 Salivary gland carcinoma Neoplasms; Stomatognathic Diseases
C0949857 BXGD011589 Mitochondrial Respiratory Chain Deficiencies Nutritional and Metabolic Diseases
C1136179 BXGD011712 Hammer Toe Musculoskeletal Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1184923 BXGD011800 Lumbar hyperlordosis Musculoskeletal Diseases
C1262113 BXGD011870 Lipohypertrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1263857 BXGD011900 Peripheral axonal neuropathy Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1280433 BXGD012125 Lipoatrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1295585 BXGD012241 Decreased vibratory sense Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328349 BXGD012463 Neuropathy ataxia and retinis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1333977 BXGD012663 Hepatitis B Virus-Related Hepatocellular Carcinoma
C1383860 BXGD012935 Cardiac Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1389102 BXGD012964 Atrophy of the spinal cord
C1397307 BXGD012996 Cardiac fibrosis
C1408174 BXGD013034 Hypertrophic neuropathy of infancy
C1408182 BXGD013035 Hereditary motor and sensory neuropathy, types I-IV
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1527344 BXGD013275 Dysphonia Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1533041 BXGD013307 Primary congenital glaucoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1696708 BXGD013504 Prehypertension Cardiovascular Diseases
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1836392 BXGD014111 Dysmetric saccades
C1836450 BXGD014117 Distal lower limb muscle weakness
C1836451 BXGD014118 Distal lower limb amyotrophy
C1836485 BXGD014123 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2A2 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1836527 BXGD014127 Distal sensory impairment of all modalities
C1837522 BXGD014244 Impaired pain sensation
C1837658 BXGD014257 Gross motor development delay Mental Disorders
C1842587 BXGD014526 Sensory axonal neuropathy
C1844806 BXGD014676 Weight less than 3rd percentile
C1847584 BXGD014876 Distal sensory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1847906 BXGD014897 Onion bulb formation
C1848736 BXGD014970 Distal amyotrophy
C1850854 BXGD015184 Increased laxity of ankles
C1853141 BXGD015307 Slow decrease in visual acuity
C1854494 BXGD015409 Slow progression
C1854919 BXGD015442 Severe psychomotor retardation
C1858285 BXGD015781 Decreased number of peripheral myelinated nerve fibers
C1858729 BXGD015825 Decreased motor nerve conduction velocity
C1859200 BXGD015862 Inability to walk by childhood/adolescence
C1861403 BXGD016045 Variable expressivity
C1866141 BXGD016379 Foot dorsiflexor weakness
C1866934 BXGD016427 Reduced tendon reflexes Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1867864 BXGD016472 Poor fine motor coordination
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1968790 BXGD016736 Axonal degeneration/regeneration
C2079538 BXGD016914 Charcot-Marie-Tooth disease, Type 2A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2132198 BXGD016930 Abnormal blistering of the skin
C2230441 BXGD016958 Triceps weakness
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2242817 BXGD017005 Homocysteine measurement
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2750440 BXGD017660 FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1
C2750441 BXGD017661 LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
C2875300 BXGD017836 Peroneal muscular atrophy (axonal type) (hypertrophic type)
C2932678 BXGD018098 Inherited Peripheral Neuropathy Nervous System Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3150651 BXGD018316 FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3276549 BXGD018691 OPTIC ATROPHY WITH OR WITHOUT DEAFNESS, OPHTHALMOPLEGIA, MYOPATHY, ATAXIA, AND NEUROPATHY
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3806301 BXGD019504 Scarring alopecia of scalp
C3839507 BXGD019774 Diminished ovarian reserve Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C3850141 BXGD019810 Acute-On-Chronic Liver Failure Digestive System Diseases
C3887499 BXGD019884 Renal cyst Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3887709 BXGD019918 Optic Neuropathy Eye Diseases; Nervous System Diseases
C4020732 BXGD020474 Mitochondrial abnormalities
C4021222 BXGD020584 Impaired temperature sensation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021800 BXGD020790 Abnormality of dental enamel
C4025614 BXGD021695 EMG: chronic denervation signs
C4025619 BXGD021698 Peripheral axonal atrophy
C4025696 BXGD021737 Paresis of extensor muscles of the big toe
C4025722 BXGD021756 Abnormality of the spinal cord
C4048158 BXGD021890 Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4049446 BXGD021933 Neointimal hyperplasia
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4310725 BXGD022640 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, AUTOSOMAL RECESSIVE, TYPE 2A2B Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4310875 BXGD022679 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2A2A
C4509226 BXGD022972 Heart failure with preserved ejection fraction [HFpEF]
C4529962 BXGD023178 Fatty Liver Disease
C4551508 BXGD023328 Dominant hereditary optic atrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C4551563 BXGD023351 Microcephaly (physical finding)
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4552766 BXGD023523 Miscarriage Female Urogenital Diseases and Pregnancy Complications
C4707897 BXGD023725 Severe early-onset axonal neuropathy due to mitofusin 2 deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721887 BXGD023781 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, AUTOSOMAL DOMINANT, TYPE 2A2A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4721916 BXGD023784 HMSN Type V Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0006198 Citric acid 192.12
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein