Showing entry for Insulin-like growth factor-binding protein complex acid labile subunit



                       
General Target Information
BXGT IdBXGT009876
Protein NameInsulin-like growth factor-binding protein complex acid labile subunit
Uniport IdP35858
GeneIGFALS
Gene Id3483
DomainLRRNT; LRR_8
Pfam PF13855   PF01462  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007155 cell adhesion
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0007165 signal transduction
molecular function GO:0005520 insulin-like growth factor binding
cellular component GO:0070062 extracellular exosome
cellular component GO:0031012 extracellular matrix
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0042567 insulin-like growth factor ternary complex
Reactome
Pathway Id Pathway Name
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-392499 Metabolism of proteins
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006309 BXGD000392 Brucellosis Infections
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0006849 BXGD000413 Oral candidiasis Infections; Stomatognathic Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014378 BXGD000912 Enterovirus Infections Infections
C0014522 BXGD000922 Epidermodysplasia Verruciformis Infections; Skin and Connective Tissue Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015644 BXGD001008 Muscular fasciculation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016053 BXGD001041 Fibromyalgia Musculoskeletal Diseases; Nervous System Diseases
C0016667 BXGD001072 Fragile X Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017921 BXGD001152 Glycogen storage disease type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0018273 BXGD001189 Growth Disorders Pathological Conditions, Signs and Symptoms
C0018524 BXGD001200 Hallucinations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0018609 BXGD001208 Hartnup Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018995 BXGD001265 Hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0021655 BXGD001508 Insulin Resistance Nutritional and Metabolic Diseases
C0022595 BXGD001562 Keratosis Follicularis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0023015 BXGD001601 Language Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024408 BXGD001768 Machado-Joseph Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026847 BXGD001940 Spinal Muscular Atrophy Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027868 BXGD002053 Neuromuscular Diseases Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029401 BXGD002135 Osteitis Deformans Musculoskeletal Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030360 BXGD002215 Papillon-Lefevre Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0030442 BXGD002223 Progressive bulbar palsy Nervous System Diseases
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0032586 BXGD002364 Polyradiculopathy Nervous System Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0034012 BXGD002449 Delayed Puberty Endocrine System Diseases
C0034013 BXGD002450 Precocious Puberty Endocrine System Diseases
C0034152 BXGD002467 Henoch-Schoenlein Purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0034372 BXGD002480 Quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0035235 BXGD002519 Respiratory Syncytial Virus Infections Infections
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0035934 BXGD002572 Rubinstein-Taybi Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038868 BXGD002781 Progressive supranuclear palsy Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0039373 BXGD002809 Tay-Sachs Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041408 BXGD002923 Turner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0042267 BXGD002974 Vaginitis Female Urogenital Diseases and Pregnancy Complications
C0042928 BXGD003014 Vocal Cord Paralysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0043116 BXGD003028 HMN (Hereditary Motor Neuropathy) Proximal Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0085084 BXGD003121 Motor Neuron Disease Nervous System Diseases
C0085632 BXGD003215 Apathy Behavior and Behavior Mechanisms
C0085633 BXGD003216 Mood swings Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0087012 BXGD003318 Ataxia, Spinocerebellar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0154671 BXGD003726 Degenerative brain disorder Nervous System Diseases
C0154682 BXGD003731 Lateral Sclerosis Nervous System Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0162534 BXGD003953 Prion Diseases Infections; Nervous System Diseases
C0205710 BXGD004112 Alpers Syndrome (disorder) Immune System Diseases; Nervous System Diseases
C0220726 BXGD004333 Diastrophic dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0232197 BXGD004536 Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0233401 BXGD004575 Psychiatric symptom
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235025 BXGD004713 Peripheral motor neuropathy Nervous System Diseases
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235950 BXGD004790 Zinc deficiency Nutritional and Metabolic Diseases
C0236642 BXGD004815 Pick Disease of the Brain Nervous System Diseases; Mental Disorders
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0265354 BXGD005529 CHARGE Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0268274 BXGD005877 Gangliosidoses, GM2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0270736 BXGD006096 Essential Tremor Nervous System Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0271742 BXGD006254 Glucocorticoid deficiency with achalasia Digestive System Diseases; Endocrine System Diseases
C0282513 BXGD006808 Primary Progressive Aphasia (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0282550 BXGD006815 Persian Gulf Syndrome Occupational Diseases
C0333463 BXGD006954 Senile Plaques Pathological Conditions, Signs and Symptoms
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0338908 BXGD007218 Mixed anxiety and depressive disorder Mental Disorders
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0342751 BXGD007542 Generalized glycogen storage disease of infants Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0349390 BXGD007899 Non-fluent aphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0349588 BXGD007933 Short stature
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0391976 BXGD008022 Pain Disorder Mental Disorders
C0392678 BXGD008063 Swallowing problem Digestive System Diseases
C0393547 BXGD008086 Bulbospinal Neuronopathy Nervous System Diseases
C0393911 BXGD008155 Pure Autonomic Failure Nervous System Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0426980 BXGD008599 Motor symptoms
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0521170 BXGD009131 Osteoporotic Fractures Wounds and Injuries
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0541764 BXGD009259 Delayed bone age
C0543859 BXGD009298 Amyotrophic Lateral Sclerosis, Guam Form Nutritional and Metabolic Diseases; Nervous System Diseases
C0553694 BXGD009409 Oropharyngeal disorders Digestive System Diseases; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0598589 BXGD009667 Inherited neuropathies Nervous System Diseases
C0686377 BXGD009834 CNS metastases Neoplasms; Nervous System Diseases
C0751072 BXGD010312 Frontotemporal Lobar Degeneration Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0751706 BXGD010559 Primary Progressive Nonfluent Aphasia Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0752121 BXGD010669 Spinocerebellar Ataxia Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0850024 BXGD010896 Gluten sensitivity Digestive System Diseases; Nutritional and Metabolic Diseases
C0878787 BXGD011392 Growth failure
C0917814 BXGD011418 Aphasia, Expressive Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0917981 BXGD011423 Progressive Muscular Atrophy Nervous System Diseases
C0920563 BXGD011469 Insulin Sensitivity Nutritional and Metabolic Diseases
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1112256 BXGD011655 Sensorimotor neuropathy
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1392786 BXGD012978 Cognitive changes Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1504404 BXGD013141 Hippocampal sclerosis
C1611743 BXGD013456 Familial (FPAH)
C1833662 BXGD013936 INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE AND FRONTOTEMPORAL DEMENTIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders
C1835580 BXGD014037 Mild postnatal growth retardation
C1837475 BXGD014236 Insulin-Like Growth Factor I Deficiency Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1837728 BXGD014259 AMYOTROPHIC LATERAL SCLEROSIS 8 (disorder) Nutritional and Metabolic Diseases; Nervous System Diseases
C1839259 BXGD014363 Bulbo-Spinal Atrophy, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1839780 BXGD014405 FRAGILE X TREMOR/ATAXIA SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1848922 BXGD014987 Hexosaminidase alpha-Subunit Deficiency (Variant B) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1850406 BXGD015140 NAVAJO NEUROHEPATOPATHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
C1862941 BXGD016145 Amyotrophic Lateral Sclerosis, Sporadic Nutritional and Metabolic Diseases; Nervous System Diseases
C1864570 BXGD016234 Insulin insensitivity
C2146481 BXGD016932 Bilateral vocal cord paralysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2718017 BXGD017522 TDP-43 Proteinopathies Nutritional and Metabolic Diseases; Nervous System Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C2931845 BXGD018076 Neurodegeneration with brain iron accumulation (NBIA) Nutritional and Metabolic Diseases; Nervous System Diseases
C3151343 BXGD018417 SPINOCEREBELLAR ATAXIA 32 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3469186 BXGD018909 HEMOCHROMATOSIS, TYPE 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3489791 BXGD018949 Parkinson Disease, Familial, Type 1 Nervous System Diseases
C3714796 BXGD019434 Isolated somatotropin deficiency
C3811918 BXGD019664 GRN-related frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C3825276 BXGD019688 Stereotyped behavior (Psychiatry)
C3887638 BXGD019906 Failure to thrive in infant Pathological Conditions, Signs and Symptoms
C3888102 BXGD019952 Frontotemporal Dementia With Motor Neuron Disease Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C3900122 BXGD020112 Acid-Labile Subunit Deficiency
C4011788 BXGD020116 Behavioral variant of frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C4024896 BXGD021461 Motor neuron atrophy
C4072897 BXGD022016 Decreased serum insulin-like growth factor 1
C4082299 BXGD022088 Bulbar palsy Nervous System Diseases
C4317045 BXGD022719 Gluten intolerance
C4321359 BXGD022750 Reduced insulin like growth factor binding protein acid labile subunit level
C4551560 BXGD023349 Truncal obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4551993 BXGD023469 Amyotrophic Lateral Sclerosis, Familial Nutritional and Metabolic Diseases; Nervous System Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002616 Copper 63.55
BXGC0002682 Zinc 65.41
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein