Showing entry for Glutamate receptor 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010295
Protein NameGlutamate receptor 3
Uniport IdP42263
GeneGRIA3
Gene Id2892
DomainANF_receptor; Lig_chan; Lig_chan-Glu_bd
Pfam PF01094   PF00060   PF10613  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.10 Environmental adaptation hsa04713 Circadian entrainment
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
5. Organismal Systems 5.6 Nervous system hsa04728 Dopaminergic synapse
5. Organismal Systems 5.6 Nervous system hsa04730 Long-term depression
6. Human Diseases 6.5 Substance dependence hsa05031 Amphetamine addiction
6. Human Diseases 6.5 Substance dependence hsa05033 Nicotine addiction
6. Human Diseases 6.1 Cancers: Overview hsa05202 Transcriptional misregulation in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007215 glutamate receptor signaling pathway
Biological Process GO:2000310 regulation of NMDA receptor activity
molecular function GO:0004971 AMPA glutamate receptor activity
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0015276 ligand-gated ion channel activity
molecular function GO:0038023 signaling receptor activity
molecular function GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
cellular component GO:0032281 AMPA glutamate receptor complex
cellular component GO:0043197 dendritic spine
cellular component GO:0030666 endocytic vesicle membrane
cellular component GO:0098688 parallel fiber to Purkinje cell synapse
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-399710 Activation of AMPA receptors
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-6794362 Protein-protein interactions at synapses
R-HSA-8849932 Synaptic adhesion-like molecules
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003125 BXGD000179 Anorexia Nervosa Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0016722 BXGD001075 Frigidity Mental Disorders
C0020295 BXGD001372 Hydronephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020594 BXGD001437 Hypoactive Sexual Desire Disorder Mental Disorders
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028768 BXGD002084 Obsessive-Compulsive Disorder Mental Disorders
C0028968 BXGD002103 Olivopontocerebellar Atrophies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0029261 BXGD002126 Orgasmic Disorder Mental Disorders
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0033953 BXGD002445 Psychosexual Disorders Mental Disorders
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0034935 BXGD002497 Babinski Reflex
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0036902 BXGD002641 Sexual Arousal Disorder Mental Disorders
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038443 BXGD002757 Stress, Psychological Behavior and Behavior Mechanisms
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0086437 BXGD003282 Joint laxity Musculoskeletal Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152235 BXGD003567 Congenital genu recurvatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0152421 BXGD003586 Macrotia
C0158486 BXGD003888 Acquired genu recurvatum Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0221356 BXGD004448 Brachycephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236642 BXGD004815 Pick Disease of the Brain Nervous System Diseases; Mental Disorders
C0239998 BXGD005012 Recurrent infections Pathological Conditions, Signs and Symptoms; Infections; Musculoskeletal Diseases
C0240379 BXGD005033 Open mouth (finding)
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0344307 BXGD007664 Absence of pain sensation Pathological Conditions, Signs and Symptoms; Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0349588 BXGD007933 Short stature
C0393484 BXGD008075 Rasmussen Syndrome Nervous System Diseases
C0399526 BXGD008251 Class III malocclusion Stomatognathic Diseases
C0423224 BXGD008475 Sunken eyes Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0427065 BXGD008604 Distal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0438696 BXGD008805 Suicidal Behavior and Behavior Mechanisms
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0546964 BXGD009348 Genu recurvatum
C0549622 BXGD009392 Sexual Dysfunction Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Mental Disorders; Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0746408 BXGD010142 mass lesion
C0796250 BXGD010826 PARTINGTON X-LINKED MENTAL RETARDATION SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1096063 BXGD011600 Drug Resistant Epilepsy Nervous System Diseases
C1136249 BXGD011715 Mental Retardation, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1387005 BXGD012953 Penis agenesis Male Urogenital Diseases
C1398312 BXGD012999 Narrow palate
C1445953 BXGD013080 Poor eye contact Mental Disorders
C1533217 BXGD013313 Methamphetamine dependence Chemically-Induced Disorders; Mental Disorders
C1833362 BXGD013919 Sleep-wake cycle disturbance
C1835095 BXGD014011 Macrodontia of permanent maxillary central incisor
C1835801 BXGD014050 Eversion of lateral third of lower eyelids Eye Diseases
C1836543 BXGD014130 Thick vermilion border
C1837658 BXGD014257 Gross motor development delay Mental Disorders
C1839839 BXGD014416 MAJOR AFFECTIVE DISORDER 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders
C1840379 BXGD014459 Cerebellar vermis hypoplasia
C1842060 BXGD014491 Prominent supraorbital ridges
C1845251 BXGD014734 Facial hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1845370 BXGD014744 Retrocerebellar cyst
C1845977 BXGD014769 X- linked recessive
C1848977 BXGD014992 Short upper lip
C1850573 BXGD015154 Slender build Pathological Conditions, Signs and Symptoms
C1851085 BXGD015191 Severe expressive language delay
C1852197 BXGD015264 MAJOR AFFECTIVE DISORDER 1 Mental Disorders
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854301 BXGD015391 Motor delay Mental Disorders
C1856117 BXGD015575 Uplifted earlobe
C1858085 BXGD015770 Malar flattening
C1861324 BXGD016029 Short philtrum
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
C1862941 BXGD016145 Amyotrophic Lateral Sclerosis, Sporadic Nutritional and Metabolic Diseases; Nervous System Diseases
C1970943 BXGD016852 MAJOR AFFECTIVE DISORDER 4 Mental Disorders
C1970945 BXGD016853 MAJOR AFFECTIVE DISORDER 6 Mental Disorders
C2678051 BXGD017396 MENTAL RETARDATION, X-LINKED 94 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2700438 BXGD017469 MAJOR AFFECTIVE DISORDER 7 Mental Disorders
C2700439 BXGD017470 MAJOR AFFECTIVE DISORDER 8 Mental Disorders
C2700440 BXGD017471 MAJOR AFFECTIVE DISORDER 9 Mental Disorders
C2919142 BXGD017867 Short Stature, CTCAE
C2930868 BXGD017909 Rasmussen subacute encephalitis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3553450 BXGD019175 Profound global developmental delay
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4022563 BXGD020918 Abnormality of muscle size
C4025790 BXGD021791 Specific learning disability
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4551993 BXGD023469 Amyotrophic Lateral Sclerosis, Familial Nutritional and Metabolic Diseases; Nervous System Diseases
C4553743 BXGD023548 Spasticity, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000434 Ethanol 46.07
BXGC0006162 L-Glutamic acid 147.13
BXGC0049516 Kainic Acid 213.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein