adisease

Showing entry for Spina Bifida

General Disease Information
BXGD Id	BXGD003107
Disease Name	Spina Bifida
Disease CUI Id	C0080178
MeSH Codes	C16 C10
Disease Class Name	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
Semantic Type	Congenital Abnormality
Human Phenotype Ontology Id	HP:0000707
Human Phenotype Ontology Term	Abnormality of the nervous system
Disease Ontology Id	DOID:7 DOID:0080015
Disease Ontology Class Name	disease of anatomical entity; physical disorder
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O14717	BXGT004083	tRNA (cytosine(38)-C(5))-methyltransferase	1787	reviewed
O14727	BXGT004084	Apoptotic protease-activating factor 1	317	reviewed
O15353	BXGT004155	Forkhead box protein N1	8456	reviewed
O43175	BXGT004575	D-3-phosphoglycerate dehydrogenase	26227	reviewed	Enzyme
O60494	BXGT004879	Cubilin	8029	reviewed
O75581	BXGT005136	Low-density lipoprotein receptor-related protein 6	4040	reviewed
O94788	BXGT005333	Retinal dehydrogenase 2	8854	reviewed	Enzyme
P00374	BXGT005520	Dihydrofolate reductase	1719	reviewed	Enzyme
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04818	BXGT006269	Thymidylate synthase	7298	reviewed	Enzyme
P05412	BXGT006354	Transcription factor AP-1	3725	reviewed	Transcription factor
P05771	BXGT006384	Protein kinase C beta type	5579	reviewed	Kinase
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P0DN79	BXGT007511	Cystathionine beta-synthase-like protein	875	reviewed
P10070	BXGT007534	Zinc finger protein GLI2	2736	reviewed
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11586	BXGT007723	C-1-tetrahydrofolate synthase, cytoplasmic	4522	reviewed	Enzyme
P13497	BXGT007915	Bone morphogenetic protein 1	649	reviewed
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P14207	BXGT007993	Folate receptor beta	2350	reviewed
P15289	BXGT008102	Arylsulfatase A	410	reviewed	Enzyme
P15328	BXGT008108	Folate receptor alpha	2348	reviewed
P16234	BXGT008209	Platelet-derived growth factor receptor alpha	5156	reviewed	Kinase
P16442	BXGT008227	Histo-blood group ABO system transferase	28	reviewed	Enzyme
P17252	BXGT008294	Protein kinase C alpha type	5578	reviewed	Kinase
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18440	BXGT008404	Arylamine N-acetyltransferase 1	9	reviewed	Enzyme
P19367	BXGT008476	Hexokinase-1	3098	reviewed	Kinase
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P23528	BXGT008879	Cofilin-1	1072	reviewed
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P27169	BXGT009161	Serum paraoxonase/arylesterase 1	5444	reviewed
P27487	BXGT009187	Dipeptidyl peptidase 4	1803	reviewed	Enzyme
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P28907	BXGT009301	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	952	reviewed	Enzyme
P29373	BXGT009337	Cellular retinoic acid-binding protein 2	1382	reviewed
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P35520	BXGT009842	Cystathionine beta-synthase	875	reviewed
P35790	BXGT009866	Choline kinase alpha	1119	reviewed	Kinase
P35916	BXGT009881	Vascular endothelial growth factor receptor 3	2324	reviewed	Kinase
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P40261	BXGT010170	Nicotinamide N-methyltransferase	4837	reviewed	Enzyme
P41440	BXGT010261	Folate transporter 1	6573	reviewed	Transporter
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42785	BXGT010338	Lysosomal Pro-X carboxypeptidase	5547	reviewed	Enzyme
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P49585	BXGT010712	Choline-phosphate cytidylyltransferase A	5130	reviewed
P54764	BXGT011078	Ephrin type-A receptor 4	2043	reviewed	Kinase
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
Q04609	BXGT012768	Glutamate carboxypeptidase 2	2346	reviewed	Enzyme
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14160	BXGT013450	Protein scribble homolog	23513	reviewed
Q14397	BXGT013467	Glucokinase regulatory protein	2646	reviewed
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q15022	BXGT013523	Polycomb protein SUZ12	23512	reviewed	Nucleic acid binding
Q6PCD5	BXGT016464	E3 ubiquitin-protein ligase RFWD3	55159	reviewed	Enzyme
Q86YC2	BXGT017633	Partner and localizer of BRCA2	79728	reviewed
Q8IYD8	BXGT018367	Fanconi anemia group M protein	57697	reviewed	Enzyme
Q8NBP7	BXGT018541	Proprotein convertase subtilisin/kexin type 9	255738	reviewed	Enzyme
Q92793	BXGT019374	CREB-binding protein	1387	reviewed
Q92887	BXGT019389	Canalicular multispecific organic anion transporter 1	1244	reviewed	Transporter
Q93088	BXGT019458	Betaine--homocysteine S-methyltransferase 1	635	reviewed
Q99496	BXGT019925	E3 ubiquitin-protein ligase RING2	6045	reviewed
Q99707	BXGT019952	Methionine synthase	4548	reviewed
Q99757	BXGT019959	Thioredoxin, mitochondrial	25828	reviewed	Enzyme
Q9H2M3	BXGT020456	S-methylmethionine--homocysteine S-methyltransferase BHMT2	23743	reviewed
Q9NPD8	BXGT021152	Ubiquitin-conjugating enzyme E2 T	29089	reviewed
Q9NPH2	BXGT021158	Inositol-3-phosphate synthase 1	51477	reviewed
Q9NPI8	BXGT021161	Fanconi anemia group F protein	2188	reviewed
Q9NW38	BXGT021230	E3 ubiquitin-protein ligase FANCL	55120	reviewed	Enzyme
Q9UBK8	BXGT021655	Methionine synthase reductase	4552	reviewed
Q9UI95	BXGT021714	Mitotic spindle assembly checkpoint protein MAD2B	10459	reviewed
Q9UMX1	BXGT021778	Suppressor of fused homolog	51684	reviewed
Q9Y617	BXGT022314	Phosphoserine aminotransferase	29968	reviewed
Q01543	BXGT023137	Friend leukemia integration 1 transcription factor	2313	reviewed	Transcription factor
P17535	BXGT023437	Transcription factor jun-D	3727	reviewed	Transcription factor
P53539	BXGT023438	Protein fosB	2354	reviewed	Transcription factor
Q15583	BXGT024027	Homeobox protein TGIF1	7050	reviewed	Enzyme
Q9UKP6	BXGT024239	Urotensin-2 receptor	2837	reviewed	G-protein coupled receptor
P13995	BXGT024486	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	10797	reviewed	Enzyme
Q13635	BXGT024910	Protein patched homolog 1	5727	reviewed
Q14807	BXGT024966	Kinesin-like protein KIF22	3835	reviewed	Cellular structure
P35251	BXGT025853	Replication factor C subunit 1	5981	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}