Showing entry for U5 small nuclear ribonucleoprotein 200 kDa helicase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005142
Protein NameU5 small nuclear ribonucleoprotein 200 kDa helicase
Uniport IdO75643
GeneSNRNP200
Gene Id23020
DomainDEAD; Helicase_C; Helicase_PWI; Sec63
Pfam PF00270   PF00271   PF18149   PF02889  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.1 Transcription hsa03040 Spliceosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000354 cis assembly of pre-catalytic spliceosome
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
molecular function GO:0005524 ATP binding
molecular function GO:0004386 helicase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0003723 RNA binding
molecular function GO:0003724 RNA helicase activity
cellular component GO:0071013 catalytic step 2 spliceosome
cellular component GO:0016020 membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005681 spliceosomal complex
cellular component GO:0071006 U2-type catalytic step 1 spliceosome
cellular component GO:0071005 U2-type precatalytic spliceosome
cellular component GO:0046540 U4/U6 x U5 tri-snRNP complex
cellular component GO:0005682 U5 snRNP
Reactome
Pathway Id Pathway Name
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72165 mRNA Splicing - Minor Pathway
R-HSA-72172 mRNA Splicing
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022578 BXGD001557 Keratoconus Eye Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0339525 BXGD007258 Autosomal dominant retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0428883 BXGD008639 Diastolic blood pressure
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476397 BXGD008991 Electroretinogram abnormal
C0554970 BXGD009428 Pallor of optic disc
C1285162 BXGD012167 Degenerative disorder Pathological Conditions, Signs and Symptoms
C1292769 BXGD012230 Precursor B-cell lymphoblastic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1835895 BXGD014063 RETINITIS PIGMENTOSA 33 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1836926 BXGD014179 Bone spicule pigmentation of the retina
C1840077 BXGD014434 Anteverted nostril
C1840457 BXGD014472 Retinal pigment epithelial atrophy
C1849367 BXGD015046 Nasal bridge wide
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C3278975 BXGD018749 Attenuation of retinal blood vessels
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021786 BXGD020779 Atypical scarring of skin Pathological Conditions, Signs and Symptoms
C4024818 BXGD021428 Progressive night blindness Eye Diseases
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0020869 Hippuristanol 462.33
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein