Showing entry for Complement C1r subcomponent


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005632
Protein NameComplement C1r subcomponent
Uniport IdP00736
GeneC1R
Gene Id715
DomainCUB; FXa_inhibition; Sushi; Trypsin
Pfam PF00431   PF00084   PF00089  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05133 Pertussis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006956 complement activation
Biological Process GO:0006958 complement activation, classical pathway
Biological Process GO:0006955 immune response
Biological Process GO:0045087 innate immune response
Biological Process GO:0030449 regulation of complement activation
Biological Process GO:0031638 zymogen activation
molecular function GO:0005509 calcium ion binding
molecular function GO:0042802 identical protein binding
molecular function GO:0004252 serine-type endopeptidase activity
molecular function GO:0008236 serine-type peptidase activity
cellular component GO:0072562 blood microparticle
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
Reactome
Pathway Id Pathway Name
R-HSA-166658 Complement cascade
R-HSA-166663 Initial triggering of complement
R-HSA-166786 Creation of C4 and C2 activators
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-977606 Regulation of Complement cascade
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000731 BXGD000002 Abdomen distended Digestive System Diseases
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003962 BXGD000244 Ascites Pathological Conditions, Signs and Symptoms
C0004368 BXGD000271 Autoimmune state
C0008031 BXGD000511 Chest Pain Pathological Conditions, Signs and Symptoms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0013720 BXGD000861 Ehlers-Danlos Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017565 BXGD001118 Gingival Hemorrhage Pathological Conditions, Signs and Symptoms; Stomatognathic Diseases
C0017572 BXGD001121 Gingival Recession Stomatognathic Diseases
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0018965 BXGD001258 Hematuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018991 BXGD001264 Hemiplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0019825 BXGD001349 Hoarseness Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0021845 BXGD001521 Intestinal Perforation Digestive System Diseases
C0023015 BXGD001601 Language Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027697 BXGD002022 Nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030524 BXGD002236 Paratuberculosis Infections; Animal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031039 BXGD002274 Pericardial effusion Cardiovascular Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0032227 BXGD002336 Pleural effusion disorder Respiratory Tract Diseases
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0034735 BXGD002487 Raynaud Phenomenon Cardiovascular Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0086437 BXGD003282 Joint laxity Musculoskeletal Diseases
C0149745 BXGD003356 Oral Ulcer Stomatognathic Diseases
C0151480 BXGD003426 Anti-nuclear factor positive Skin and Connective Tissue Diseases
C0151632 BXGD003450 ESR raised
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0162154 BXGD003922 Atrophic scar Pathological Conditions, Signs and Symptoms
C0221021 BXGD004368 Microangiopathic hemolytic anemia Hemic and Lymphatic Diseases
C0232513 BXGD004553 Premature tooth loss Stomatognathic Diseases
C0234428 BXGD004666 Disturbance of consciousness
C0240340 BXGD005031 Microdontia (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0241074 BXGD005078 Hyperextensible skin
C0266052 BXGD005614 Precocious exfoliation of primary tooth Stomatognathic Diseases
C0268347 BXGD005907 Ehlers-Danlos Syndrome, Type VIII Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0272242 BXGD006330 Complement deficiency disease Immune System Diseases; Hemic and Lymphatic Diseases
C0277942 BXGD006486 Butterfly rash Skin and Connective Tissue Diseases
C0311370 BXGD006882 Lupus anticoagulant disorder Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0333463 BXGD006954 Senile Plaques Pathological Conditions, Signs and Symptoms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0349588 BXGD007933 Short stature
C0376480 BXGD007998 Gingival Overgrowth Stomatognathic Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0423757 BXGD008504 Thin skin
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0426396 BXGD008559 Urine looks dark
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0542514 BXGD009277 Blue sclera Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0815107 BXGD010861 psychological distress
C1142517 BXGD011757 Lupus anticoagulant measurement
C1290511 BXGD012188 Anodontia of Permanent Dentition Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1837512 BXGD014243 Decreased serum complement C3
C1842774 BXGD014536 Hypermelanotic macule
C1844592 BXGD014649 Soft skin
C1851789 BXGD015233 Poor wound healing
C1855642 BXGD015519 Atrophy of alveolar ridges
C1856714 BXGD015634 Palmoplantar cutis laxa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1858981 BXGD015839 Antineutrophil antibody positivity
C2919142 BXGD017867 Short Stature, CTCAE
C2936349 BXGD018109 Plaque, Amyloid Pathological Conditions, Signs and Symptoms
C2985280 BXGD018223 Blood Protein Measurement
C3553764 BXGD019187 Joint hyperflexibility
C4019436 BXGD020467 Antiphospholipid antibody positivity
C4023588 BXGD021223 Abnormality of the gastrointestinal tract Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C4073169 BXGD022058 Decreased serum complement C4
C4310681 BXGD022622 EHLERS-DANLOS SYNDROME, PERIODONTAL TYPE, 2
C4315963 BXGD022696 Alveolar bone loss around teeth
C4321325 BXGD022748 Lupus anticoagulant -- finding
C4477095 BXGD022922 Increased lactate dehydrogenase activity
C4551499 BXGD023322 EHLERS-DANLOS SYNDROME, PERIODONTAL TYPE, 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0002682 Zinc 65.41
BXGC0014116 Lysine 147.11
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein