Showing entry for Apolipoprotein A-II


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005910
Protein NameApolipoprotein A-II
Uniport IdP02652
GeneAPOA2
Gene Id336
DomainApoA-II
Pfam PF04711  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa03320 PPAR signaling pathway
5. Organismal Systems 5.4 Digestive system hsa04979 Cholesterol metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002526 acute inflammatory response
Biological Process GO:0031100 animal organ regeneration
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0033344 cholesterol efflux
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0030301 cholesterol transport
Biological Process GO:0034378 chylomicron assembly
Biological Process GO:0034371 chylomicron remodeling
Biological Process GO:0046340 diacylglycerol catabolic process
Biological Process GO:0034380 high-density lipoprotein particle assembly
Biological Process GO:0034384 high-density lipoprotein particle clearance
Biological Process GO:0034375 high-density lipoprotein particle remodeling
Biological Process GO:0042157 lipoprotein metabolic process
Biological Process GO:0034374 low-density lipoprotein particle remodeling
Biological Process GO:0060621 negative regulation of cholesterol import
Biological Process GO:0032375 negative regulation of cholesterol transport
Biological Process GO:0060695 negative regulation of cholesterol transporter activity
Biological Process GO:0002719 negative regulation of cytokine production involved in immune response
Biological Process GO:0060192 negative regulation of lipase activity
Biological Process GO:0050995 negative regulation of lipid catabolic process
Biological Process GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling
Biological Process GO:0018206 peptidyl-methionine modification
Biological Process GO:0006656 phosphatidylcholine biosynthetic process
Biological Process GO:0009395 phospholipid catabolic process
Biological Process GO:0033700 phospholipid efflux
Biological Process GO:0010873 positive regulation of cholesterol esterification
Biological Process GO:0032757 positive regulation of interleukin-8 production
Biological Process GO:0050996 positive regulation of lipid catabolic process
Biological Process GO:0050766 positive regulation of phagocytosis
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0018158 protein oxidation
Biological Process GO:0050821 protein stabilization
Biological Process GO:0030300 regulation of intestinal cholesterol absorption
Biological Process GO:0019216 regulation of lipid metabolic process
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:0042493 response to drug
Biological Process GO:0043627 response to estrogen
Biological Process GO:0051384 response to glucocorticoid
Biological Process GO:0009749 response to glucose
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0043691 reverse cholesterol transport
Biological Process GO:0006641 triglyceride metabolic process
Biological Process GO:0034370 triglyceride-rich lipoprotein particle remodeling
Biological Process GO:0016032 viral process
molecular function GO:0034190 apolipoprotein receptor binding
molecular function GO:0015485 cholesterol binding
molecular function GO:0120020 cholesterol transfer activity
molecular function GO:0031072 heat shock protein binding
molecular function GO:0008035 high-density lipoprotein particle binding
molecular function GO:0070653 high-density lipoprotein particle receptor binding
molecular function GO:0055102 lipase inhibitor activity
molecular function GO:0008289 lipid binding
molecular function GO:0005319 lipid transporter activity
molecular function GO:0031210 phosphatidylcholine binding
molecular function GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
molecular function GO:0005543 phospholipid binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0005102 signaling receptor binding
cellular component GO:0072562 blood microparticle
cellular component GO:0042627 chylomicron
cellular component GO:0005829 cytosol
cellular component GO:0005769 early endosome
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0034364 high-density lipoprotein particle
cellular component GO:0034366 spherical high-density lipoprotein particle
cellular component GO:0034361 very-low-density lipoprotein particle
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-1989781 PPARA activates gene expression
R-HSA-2187338 Visual phototransduction
R-HSA-2187338 Visual phototransduction
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-382551 Transport of small molecules
R-HSA-388396 GPCR downstream signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-392499 Metabolism of proteins
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-418594 G alpha (i) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-556833 Metabolism of lipids
R-HSA-597592 Post-translational protein modification
R-HSA-6806667 Metabolism of fat-soluble vitamins
R-HSA-6806667 Metabolism of fat-soluble vitamins
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-8963888 Chylomicron assembly
R-HSA-8963898 Plasma lipoprotein assembly
R-HSA-8963899 Plasma lipoprotein remodeling
R-HSA-8963901 Chylomicron remodeling
R-HSA-975634 Retinoid metabolism and transport
R-HSA-975634 Retinoid metabolism and transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0003742 BXGD000218 Arcus Senilis Eye Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007766 BXGD000478 Intracranial Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020474 BXGD001397 Hyperlipidemia, Familial Combined Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020479 BXGD001399 Hyperlipoproteinemia Type III Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0023195 BXGD001614 Lecithin Acyltransferase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027719 BXGD002027 Nephrosclerosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030409 BXGD002217 Paracoccidioidomycosis Infections
C0037315 BXGD002687 Sleep Apnea Syndromes Respiratory Tract Diseases; Nervous System Diseases
C0039292 BXGD002807 Tangier Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0042384 BXGD002979 Vasculitis Cardiovascular Diseases
C0042721 BXGD002997 Viral hepatitis Digestive System Diseases; Infections
C0154251 BXGD003710 Lipid Metabolism Disorders Nutritional and Metabolic Diseases
C0155210 BXGD003780 Eyelid Xanthoma Nutritional and Metabolic Diseases; Eye Diseases
C0162565 BXGD003957 Acute intermittent porphyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0178664 BXGD004032 Glomerulosclerosis (disorder) Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0221014 BXGD004364 Reactive systemic amyloidosis Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0268380 BXGD005921 Systemic amyloidosis Nutritional and Metabolic Diseases
C0268406 BXGD005935 Age-related amyloidosis Nutritional and Metabolic Diseases
C0281479 BXGD006776 Primary Systemic Amyloidosis Neoplasms; Nutritional and Metabolic Diseases; Immune System Diseases
C0302314 BXGD006837 Xanthoma Nutritional and Metabolic Diseases
C0342883 BXGD007574 Cholesteryl Ester Transfer Protein Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0342895 BXGD007579 Fish-Eye Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0740340 BXGD009978 Amyloidosis, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0948242 BXGD011519 Nuchal bleb, familial Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C1279945 BXGD012124 Acute interstitial pneumonia Respiratory Tract Diseases
C1704417 BXGD013557 Hyperlipoproteinemia Type IIb Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1845050 BXGD014703 PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1867743 BXGD016470 Premature coronary artery atherosclerosis Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C2609129 BXGD017167 Autoimmune pancreatitis Digestive System Diseases; Immune System Diseases
C2712907 BXGD017491 obsolete Combined hyperlipidemia
C3149462 BXGD018280 HYPERALPHALIPOPROTEINEMIA 1
C3536715 BXGD019070 AA amyloidosis Nutritional and Metabolic Diseases
C3714619 BXGD019418 Insulin resistance syndrome Nutritional and Metabolic Diseases
C3888506 BXGD019974 LDLR mutation
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002616 Copper 63.55
BXGC0002682 Zinc 65.41
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein