Showing entry for Collagen alpha-2(IV) chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006791
Protein NameCollagen alpha-2(IV) chain
Uniport IdP08572
GeneCOL4A2
Gene Id1284
DomainC4; Collagen
Pfam PF01413   PF01391  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04512 ECM-receptor interaction
5. Organismal Systems 5.2 Endocrine system hsa04926 Relaxin signaling pathway
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04933 AGE-RAGE signaling pathway in diabetic complications
5. Organismal Systems 5.4 Digestive system hsa04974 Protein digestion and absorption
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05146 Amoebiasis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05222 Small cell lung cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007568 aging
Biological Process GO:0001525 angiogenesis
Biological Process GO:0071560 cellular response to transforming growth factor beta stimulus
Biological Process GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway
Biological Process GO:0035987 endodermal cell differentiation
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0016525 negative regulation of angiogenesis
Biological Process GO:0014823 response to activity
Biological Process GO:0006351 transcription, DNA-templated
molecular function GO:0005201 extracellular matrix structural constituent
molecular function GO:0030020 extracellular matrix structural constituent conferring tensile strength
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0005587 collagen type IV trimer
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0070062 extracellular exosome
cellular component GO:0031012 extracellular matrix
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1442490 Collagen degradation
R-HSA-1442490 Collagen degradation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1474244 Extracellular matrix organization
R-HSA-1474244 Extracellular matrix organization
R-HSA-1474290 Collagen formation
R-HSA-162582 Signal Transduction
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-186797 Signaling by PDGF
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-216083 Integrin cell surface interactions
R-HSA-216083 Integrin cell surface interactions
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-2214320 Anchoring fibril formation
R-HSA-2243919 Crosslinking of collagen fibrils
R-HSA-3000157 Laminin interactions
R-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-3000480 Scavenging by Class A Receptors
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-419037 NCAM1 interactions
R-HSA-422475 Axon guidance
R-HSA-5653656 Vesicle-mediated transport
R-HSA-8948216 Collagen chain trimerization
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0005845 BXGD000341 Blood urea nitrogen measurement
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012739 BXGD000786 Disseminated Intravascular Coagulation Hemic and Lymphatic Diseases
C0017654 BXGD001136 Glomerular Filtration Rate
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018991 BXGD001264 Hemiplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022578 BXGD001557 Keratoconus Eye Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023508 BXGD001675 White Blood Cell Count procedure
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023976 BXGD001724 Long QT Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026205 BXGD001891 Miosis disorder Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027697 BXGD002022 Nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027706 BXGD002023 Hereditary nephritis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0032002 BXGD002320 Pituitary Diseases Nervous System Diseases; Endocrine System Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0039585 BXGD002821 Androgen-Insensitivity Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0085220 BXGD003142 Cerebral Amyloid Angiopathy Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151699 BXGD003461 Intracranial Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0151860 BXGD003490 Acquired porencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0152021 BXGD003520 Congenital heart disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0205682 BXGD004105 Waist-Hip Ratio
C0221290 BXGD004439 Chondromyxoid fibroma Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236734 BXGD004823 Caffeine related disorders
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0266484 BXGD005681 Schizencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0302892 BXGD006864 Congenital porencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0338484 BXGD007188 Familial Hemiplegic Migraine Nervous System Diseases
C0338502 BXGD007192 Hypoplasia of the optic nerve Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0346629 BXGD007831 Malignant neoplasm of large intestine Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0403440 BXGD008283 Thin basement membrane disease Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0428883 BXGD008639 Diastolic blood pressure
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0521707 BXGD009166 Bilateral cataracts (disorder) Eye Diseases
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0877015 BXGD011327 Pelvic Organ Prolapse Pathological Conditions, Signs and Symptoms
C0917804 BXGD011413 Arteriovenous Malformations, Cerebral Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1302401 BXGD012303 Adenoma of large intestine Digestive System Diseases; Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1328840 BXGD012474 Autoimmune Lymphoproliferative Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C1445957 BXGD013081 Serum total cholesterol measurement
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1611184 BXGD013455 Calcification of coronary artery Nutritional and Metabolic Diseases; Cardiovascular Diseases
C1837315 BXGD014218 COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
C1842247 BXGD014508 CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1 Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1842937 BXGD014546 AURAL ATRESIA, CONGENITAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1861403 BXGD016045 Variable expressivity
C1867983 BXGD016479 PORENCEPHALY, FAMILIAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2364082 BXGD017123 Sense of smell impaired Nervous System Diseases
C2673195 BXGD017188 Angiopathy, Hereditary, With Nephropathy, Aneurysms, And Muscle Cramps Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C2675481 BXGD017292 COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
C2677123 BXGD017364 COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
C2733158 BXGD017562 Cerebral Small Vessel Diseases Nervous System Diseases; Cardiovascular Diseases
C2919945 BXGD017882 Cavernous Hemangioma of Brain Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C2937358 BXGD018159 Cerebral Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C2938912 BXGD018165 Hyperintensity of cerebral white matter on MRI Pathological Conditions, Signs and Symptoms
C3178801 BXGD018538 Stroke, Lacunar Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C3278923 BXGD018748 Dilated ventricles (finding)
C3280970 BXGD018872 PORENCEPHALY 2
C3281105 BXGD018882 HEMORRHAGE, INTRACEREBRAL, SUSCEPTIBILITY TO
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3554460 BXGD019215 COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
C3698507 BXGD019373 Post-traumatic Porencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C4082172 BXGD022086 Porencephalic cyst
C4082173 BXGD022087 Porencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C4082301 BXGD022089 Developmental Porencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C4551998 BXGD023472 Porencephaly, Type 1, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C4553743 BXGD023548 Spasticity, CTCAE
C4707565 BXGD023718 Bilateral polymicrogyria
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein