Showing entry for Alpha-2-antiplasmin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006815
Protein NameAlpha-2-antiplasmin
Uniport IdP08697
GeneSERPINF2
Gene Id5345
DomainSerpin
Pfam PF00079  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006953 acute-phase response
Biological Process GO:0048514 blood vessel morphogenesis
Biological Process GO:0030199 collagen fibril organization
Biological Process GO:0042730 fibrinolysis
Biological Process GO:0010951 negative regulation of endopeptidase activity
Biological Process GO:0051918 negative regulation of fibrinolysis
Biological Process GO:0010757 negative regulation of plasminogen activation
Biological Process GO:0002576 platelet degranulation
Biological Process GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin
Biological Process GO:0045597 positive regulation of cell differentiation
Biological Process GO:0032967 positive regulation of collagen biosynthetic process
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0046330 positive regulation of JNK cascade
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:0051496 positive regulation of stress fiber assembly
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0071636 positive regulation of transforming growth factor beta production
Biological Process GO:0002034 regulation of blood vessel diameter by renin-angiotensin
Biological Process GO:0010033 response to organic substance
molecular function GO:0004866 endopeptidase inhibitor activity
molecular function GO:0002020 protease binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004867 serine-type endopeptidase inhibitor activity
cellular component GO:0072562 blood microparticle
cellular component GO:0009986 cell surface
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005577 fibrinogen complex
cellular component GO:0031093 platelet alpha granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-114608 Platelet degranulation
R-HSA-75205 Dissolution of Fibrin Clot
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0006271 BXGD000384 Bronchiolitis Infections; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011119 BXGD000698 Decompression Sickness Wounds and Injuries
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0017565 BXGD001118 Gingival Hemorrhage Pathological Conditions, Signs and Symptoms; Stomatognathic Diseases
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018924 BXGD001249 Hemarthrosis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0018965 BXGD001258 Hematuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019087 BXGD001280 Hemorrhagic Disorders Hemic and Lymphatic Diseases
C0019123 BXGD001288 Hemothorax Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0019243 BXGD001308 Angioedemas, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020476 BXGD001398 Hyperlipoproteinemias Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022336 BXGD001535 Creutzfeldt-Jakob disease Infections; Nervous System Diseases; Mental Disorders
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027831 BXGD002047 Neurofibromatosis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0034065 BXGD002454 Pulmonary Embolism Respiratory Tract Diseases; Cardiovascular Diseases
C0034155 BXGD002468 Purpura, Thrombotic Thrombocytopenic Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0035455 BXGD002554 Rhinitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0038160 BXGD002734 Staphylococcal Infections Infections
C0038395 BXGD002753 Streptococcal Infections Infections
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0042029 BXGD002951 Urinary tract infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0080233 BXGD003110 Tooth Loss Stomatognathic Diseases
C0085082 BXGD003119 Fungemia Pathological Conditions, Signs and Symptoms; Infections
C0085281 BXGD003152 Addictive Behavior Behavior and Behavior Mechanisms
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0151699 BXGD003461 Intracranial Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0151825 BXGD003481 Bone pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0162557 BXGD003956 Liver Failure, Acute Digestive System Diseases
C0162678 BXGD003974 Neurofibromatoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0202239 BXGD004087 Uric acid measurement (procedure)
C0206062 BXGD004148 Lung Diseases, Interstitial Respiratory Tract Diseases
C0233524 BXGD004587 Falsification Behavior and Behavior Mechanisms
C0237123 BXGD004845 Alcohol or Other Drugs use
C0240412 BXGD005034 Muscle hematoma Pathological Conditions, Signs and Symptoms
C0266929 BXGD005722 Chronic Periodontitis Stomatognathic Diseases
C0267941 BXGD005793 Pancreatitis, Acute Necrotizing Digestive System Diseases
C0272274 BXGD006334 Familial hemorrhagic diathesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0311370 BXGD006882 Lupus anticoagulant disorder Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0333208 BXGD006933 Fibrin thrombus Cardiovascular Diseases
C0333274 BXGD006940 Purulent discharge
C0333519 BXGD006958 Caries (morphologic abnormality) Pathological Conditions, Signs and Symptoms
C0343401 BXGD007623 MRSA - Methicillin resistant Staphylococcus aureus infection Infections
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0398620 BXGD008200 Alpha-2-antiplasmin deficiency
C0398621 BXGD008201 Hypoplasminogenemia Hemic and Lymphatic Diseases
C0398623 BXGD008202 Thrombophilia Hemic and Lymphatic Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0476227 BXGD008981 pricking of skin
C0477316 BXGD008997 Other specified coagulation defects Hemic and Lymphatic Diseases
C0523465 BXGD009209 Serum albumin measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0856825 BXGD011118 Acute GVH disease Immune System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1112433 BXGD011667 Thromboembolic stroke Cardiovascular Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1266184 BXGD011991 Atypical Teratoid Rhabdoid Tumor Neoplasms
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1456399 BXGD013116 Crushing sensation
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1844374 BXGD014626 Persistent bleeding after trauma
C1847800 BXGD014889 Waardenburg Syndrome Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1963077 BXGD016680 Bone Pain, CTCAE 3.0
C2752081 BXGD017767 ALPHA-2-PLASMIN INHIBITOR DEFICIENCY Hemic and Lymphatic Diseases
C2931672 BXGD018045 Cerebral hemorrhage with amyloidosis, hereditary, Dutch type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C3489734 BXGD018946 Anti-plasmin deficiency, congenital Hemic and Lymphatic Diseases
C3826157 BXGD019715 Hypertension in children
C4023145 BXGD021123 Abnormal umbilical stump bleeding
C4025886 BXGD021846 Severe periodontitis Stomatognathic Diseases
C4280701 BXGD022386 Reduced euglobulin clot lysis time
C4551689 BXGD023393 Sleep-Disordered Breathing Respiratory Tract Diseases; Nervous System Diseases
C4554063 BXGD023559 Bone Pain, CTCAE 5.0
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002616 Copper 63.55
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein